Measurement of the derivative 'ZW' for an oscillating aerofoil

This report presents the results of experimental measurements of the damping derivative coefficient zw for constant chord rigid wings of various aspect ratios having sweepback angles of zero and 450. The results for the rectangular wings Flow substantial agreement with the unsteady aerofoil theory developed by TI.P. Jones $2) The dependence of Zvi upon frequency parameter is as given by theory and is much less than for two dimensional flow, but the numerical results are approximately 10 per cent below the theoretical. This is attributed to the large trailing edge angle 22° of the N.A.C.A. 0020 section used for the model aerofoils. The effect of sweepback is to decrease the numerical value of z , but this effect is much less pronounced, for low than for high aspect ratios. For aspect ratios 5 and 3 the numerical value is greater than would be given by a factor of proportionality equal to the cosine of the angle of sweepback. The measurements were corrected for tunnel interference by a method based on the theoretical work of 7.P.Jones.(1

Utilising a Combined Exercise and Counselling Program to Examine the Relationship Between Emotional Self-Efficacy and Physiological Improvements in Breast Cancer Survivors

Breast cancer diagnosis in women has increased in recent years, though medical progress has helped more patients become survivors rather than victims. With cancer diagnosis and treatment, however, comes a host of psychological and physical side effects that must be addressed. Research has found exercise and counselling may decrease the detrimental effects of breast cancer, but programs have typically utilised these modalities separately. As psychosocial issues appear correlated with physical health, it is imperative to examine the mind-body connection and explore the benefits of a combination exercise and counselling program. One psychological variable of interest is emotional self-efficacy, which relates to how capable one is of recognising and regulating emotions and may influence overall well-being and survival. This study explored if participation in such a program improved emotional self-efficacy and physiological health, and if self-efficacy levels correlated with other variables. A 20-week intervention was utilised, consisting of two phases. During the first eight weeks, participants (n=19) were randomised among four groups: exercise-only (Ex; n=5), counselling-only (C; n=5), exercise and counselling (ExC; n=5), or usual care control (UsC; n=4). After these 8 weeks in separate intervention groups, all women were enrolled in exercise and counselling for the remaining 12 weeks of the 20-week study. Emotional self-efficacy and physiological parameters (cardiorespiratory endurance, upper and lower body strength, and flexibility) were assessed at baseline, 8 weeks, and 20 weeks. Non-parametric testing was utilised to examine betweengroup and within-group changes in the variables of interest. Results indicated all groups were balanced at baseline for all parameters except age and radiation treatment. Eight-week findings indicated C, E, and ExC all improved emotional self-efficacy when compared to UsC (p=0.052), with the greatest score improvement observed in ExC (median=17.3). This finding suggests a program utilising both exercise and counselling may be most beneficial for improving selfefficacy. Additionally, both Ex and ExC improved in the physiological variables of interest compared to C and UsC, though only the increase in upper-body strength reached statistical significance (p=0.010). At the end of the 20 weeks, once all participants had undertaken at least 12 weeks of exercise and counselling, no significant differences remained between groups. These results indicate a catch-up effect occurred, with 12 weeks of exercise and counselling sufficient to produce beneficial changes. No correlations were observed between adherence and emotional self-efficacy, while negative correlations were observed between baseline emotional self-efficacy scores and both overall self-efficacy changes and flexibility changes. No adverse effects or new or worsened cases of lymphoedema resulted from participation in the 20-week program. Results from this study suggested combining exercise and counselling benefits both physical and psychosocial parameters, improving emotional self-efficacy more than exercise or counselling alone, with significant improvements achieved in a short time. Additionally, those with low emotional self-efficacy may have the most to gain from such an intervention. Findings from this study increased knowledge on the efficiency of a combined exercise and counselling program on addressing both physical and psychological side-effects of breast cancer. These findings can provide guidance for the implementation of such programs in the healthcare setting. Assisting post-treatment breast cancer patients to strengthen both their minds and bodies may help improve their overall quality of life and, ultimately, survivorship. This thesis is submitted in partial fulfilment of the requirement for the degree of Master of Health Sciences of the University of Notre Dame Australia, Fremantle Campus, School of Health Science

Igneous Rock Associations in Canada 3. Large Igneous Provinces (LIPs) in Canada and Adjacent Regions: 3 Ga to Present

Earth history is punctuated by numerous periods during which large volumes of mafic magma were emplaced. Such magmas not generated by a 'normal' spreading ridge or by subduction are termed Large Igneous Provinces (LIPs), and consist of continental flood basalts, volcanic rifted margins, oceanic plateaus, ocean basin flood basalts, submarine ridges, and seamount chains. Associated felsic rocks may also be present. LIPs of Mesozoic and Cenozoic age are typically the best preserved. Those of Paleozoic and Proterozoic age are usually more deeply eroded, and consist of flood basalt remnants and a deep-level plumbing system (of giant dyke swarms, sill provinces and layered intrusions). In the Archean the most promising LIP candidates are greenstone belts containing komatiites. Many LIPs have been linked to regional-scale uplift, continental rifting and breakup, and climatic crises. They can be used as precisely dated time markers in the stratigraphic record, and are key targets for Ni-Cu-PGE exploration. LIPs have also become a focus in the debate on the existence and nature of mantle plumes. Canada has a rich record of LIPs. At least 80 candidates are recognized in Canada and adjacent regions, with ages ranging from 3100 to 17 Ma. We review proposed links between the LIP record of Canada and mantle plumes, continental breakup, regional uplift, and ore deposits. However, given that many mafic units in Canada remain poorly characterized, a concerted geochronology campaign with integrated paleomagnetism and geochemistry would be invaluable in expanding the application of the Canadian LIP record to solving major geological problems. RÉSUMÉ L'histoire de la Terre est ponctuée de nombreuses périodes de mise en place de forts volumes de magma mafiques. De tels magmas qui ne sont pas issus de zones d'expansion « normale » ou de subduction sont appelés Grandes provinces ignées (GPI), et celles-ci sont constituées de basaltes d'épanchements continentaux, de marges de fosse volcaniques, de plateaux océaniques, d'épanchements de basaltes de bassins océaniques, de crêtes sous-marines, et de chaînes de monts sous-marines. Peuvent également y être associées des suites de roches felsiques. Généralement, les GPI du Mésozoïque et du Cénozoïque sont les mieux préservées. Celles du Protérozoïque et du Paléozoïque sont généralement plus fortement érodées et sont constituées de vestiges de basaltes d'épanchement et des réseaux de conduits d'origine (réseaux géants de dykes, provinces de filons-couches et d'intrusifs stratifiées). Dans l'Archéen, les meilleurs candidats sont représentés par les bandes de roches vertes à komatiites. De nombreuses GPI ont été associées à des épisodes de soulèvement régionaux, de dérives ou de fragmentations continentales, ainsi qu'à des crises climatiques. Elles peuvent servir de marqueurs temporels stratigraphiques et sont des cibles de première importance dans l'exploration de gisements de Cu-Ni-ÉGP. Les GPI sont aussi devenues des arguments très considérés dans le débat sur l'existence et la nature des panaches mantelliques. Le Canada possède de riches archives de GPI, et au moins 80 candidatures ont été isolées sur le territoire canadien et dans les régions adjacentes, leur âge délimitant une fourchette allant de 3 100 Ma à 17 Ma. Nous passons en revue les liens proposés entre la suite des GDI canadiennes d'une part, et celle des panaches mantelliques, des fragmentations continentales, des soulèvements régionaux, et des gisements minéraux, d'autre part. Toutefois, vu le piètre état de caractérisation des unités mafiques au Canada, une campagne de caractérisation géochronologique, paléomagnétique et géochimique serait d'une valeur inestimable pour favoriser l'utilisation des GDI canadiennes pour nous aider à solutionner de grands problèmes géologiques

Scalable web services for the PSIPRED Protein Analysis Workbench

Here, we present the new UCL Bioinformatics Group’s PSIPRED Protein Analysis Workbench. The Workbench unites all of our previously available analysis methods into a single web-based framework. The new web portal provides a greatly streamlined user interface with a number of new features to allow users to better explore their results. We offer a number of additional services to enable computationally scalable execution of our prediction methods; these include SOAP and XML-RPC web server access and new HADOOP packages. All software and services are available via the UCL Bioinformatics Group website at http://bioinf.cs.ucl.ac.uk/

Task shifting and sharing in maternal and reproductive health in low-income countries: A narrative synthesis of current evidence

Reducing maternal mortality and providing universal access to reproductive health in resource poor settings has been severely constrained by a shortage of health workers required to deliver interventions. The aim of this article is to determine evidence to optimize health worker roles through task shifting/sharing to address Millennium Development Goal 5 and reduce maternal mortality and provide universal access to reproductive health. A narrative synthesis of peer-reviewed literature from 2000 to 2011 was undertaken with retrieved documents assessed using an inclusion/exclusion criterion and quality appraisal guided by critical assessment tools. Concepts were analysed thematically. The analysis identified a focus on clinical tasks (the delivery of obstetric surgery, anaesthesia and abortion) that were shifted to and/or shared with doctors, non-physician clinicians, nurses and midwives. Findings indicate that shifting and sharing these tasks may increase access to and availability of maternal and reproductive health (MRH) services without compromising performance or patient outcomes and may be cost effective. However, a number of issues and barriers were identified with health workers calling for improved in-service training, supervision, career progression and incentive packages to better support their practice. Collaborative approaches involving community members and health workers at all levels have the potential to deliver MRH interventions effectively if accompanied by ongoing investment in the health care system. © 2013 The Author. All rights reserved

What difference does ("good") HRM make?

The importance of human resources management (HRM) to the success or failure of health system performance has, until recently, been generally overlooked. In recent years it has been increasingly recognised that getting HR policy and management "right" has to be at the core of any sustainable solution to health system performance. In comparison to the evidence base on health care reform-related issues of health system finance and appropriate purchaser/provider incentive structures, there is very limited information on the HRM dimension or its impact. Despite the limited, but growing, evidence base on the impact of HRM on organisational performance in other sectors, there have been relatively few attempts to assess the implications of this evidence for the health sector. This paper examines this broader evidence base on HRM in other sectors and examines some of the underlying issues related to "good" HRM in the health sector. The paper considers how human resource management (HRM) has been defined and evaluated in other sectors. Essentially there are two sub-themes: how have HRM interventions been defined? and how have the effects of these interventions been measured in order to identify which interventions are most effective? In other words, what is "good" HRM? The paper argues that it is not only the organisational context that differentiates the health sector from many other sectors, in terms of HRM. Many of the measures of organisational performance are also unique. "Performance" in the health sector can be fully assessed only by means of indicators that are sector-specific. These can focus on measures of clinical activity or workload (e.g. staff per occupied bed, or patient acuity measures), on measures of output (e.g. number of patients treated) or, less frequently, on measures of outcome (e.g. mortality rates or rate of post-surgery complications). The paper also stresses the need for a "fit" between the HRM approach and the organisational characteristics, context and priorities, and for recognition that so-called "bundles" of linked and coordinated HRM interventions will be more likely to achieve sustained improvements in organisational performance than single or uncoordinated interventions

High-Frequency Jet Ventilation During Cryoablation of Small Renal Tumours

AIM: To evaluate the effect of high-frequency jet ventilation (HFJV) in place of standard intermittent positive-pressure ventilation (IPPV) on procedure duration, patient radiation dose, complication rates, and outcomes during CT-guided cryoablation of small renal tumours. MATERIALS AND METHODS: One hundred consecutive CT-guided cryoablation procedures to treat small renal tumours under general anaesthesia were evaluated-50 with standard IPPV and 50 after the introduction of HFJV as standard practice. Anaesthesia and procedural times, ionising radiation dose, complications, and 1-month post-treatment outcomes were collected. RESULTS: HFJV was feasible and safe in all cases. Mean procedure time and total anaesthetic time were shorter with HFJV (p = <0.0001). The number of required CT acquisitions (p = 0.0002) and total procedure patient radiation dose (p = 0.0027) were also lower in the HFJV group compared with the IPPV group. There were a total of four complications of Clavien-Dindo classification 3 or above-three in the IPPV group and one in the HFJV group. At 1-month follow-up, two cases (both in the IPPV group) demonstrated subtotal treatment. Both cases were subsequently successfully retreated with cryoablation. CONCLUSION: By reducing target tumour motion during CT-guided renal cryoablation, HFJV can reduce procedure times and exposure to ionising radiation. HFJV provides an important adjunct to complex image-guided interventions, with potential to improve safety and treatment outcomes

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis

Objective: First-degree atrioventricular block is frequently encountered in clinical practice and is generally considered a benign process. However, there is emerging evidence that prolonged PR interval may be associated with adverse outcomes. This study aims to determine if prolonged PR interval is associated with adverse cardiovascular outcomes and mortality. Methods: We searched MEDLINE and EMBASE for studies that evaluated clinical outcomes associated with prolonged and normal PR intervals. Relevant studies were pooled using random effects meta-analysis for risk of mortality, cardiovascular mortality, heart failure, coronary heart disease, atrial fibrillation and stroke or transient ischaemic attack (TIA). Sensitivity analyses were performed considering the population type and the use of adjustments. Results: Our search yielded 14 studies that were undertaken between 1972 and 2011 with 400 750 participants. Among the studies that adjusted for potential confounders, the pooled results suggest an increased risk of mortality with prolonged PR interval risk ratio (RR) 1.24 95% CI 1.02 to 1.51, five studies. Prolonged PR interval was associated with significant risk of heart failure or left ventricular dysfunction (RR 1.39 95% CI 1.18 to 1.65, three studies) and atrial fibrillation (RR 1.45 95% CI 1.23 to 1.71, eight studies) but not cardiovascular mortality, coronary heart disease or myocardial infarction or stroke or TIA. Similar observations were recorded when limited to studies of first-degree heart block. Conclusions: Data from observational studies suggests a possible association between prolonged PR interval and significant increases in atrial fibrillation, heart failure and mortality. Future prospective studies are needed to confirm the relationships reported, consider possible mechanisms and define the optimal monitoring strategy for such patients

Long-term glycemic variability and risk of adverse outcomes: a systematic review and meta-analysis

OBJECTIVE: Glycemic variability is emerging as a measure of glycemic control, which may be a reliable predictor of complications. This systematic review and meta-analysis evaluates the association between HbA1c variability and micro- and macrovascular complications and mortality in type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS: Medline and Embase were searched (2004–2015) for studies describing associations between HbA1c variability and adverse outcomes in patients with type 1 and type 2 diabetes. Data extraction was performed independently by two reviewers. Random-effects meta-analysis was performed with stratification according to the measure of HbA1c variability, method of analysis, and diabetes type. RESULTS: Seven studies evaluated HbA1c variability among patients with type 1 diabetes and showed an association of HbA1c variability with renal disease (risk ratio 1.56 [95% CI 1.08–2.25], two studies), cardiovascular events (1.98 [1.39–2.82]), and retinopathy (2.11 [1.54–2.89]). Thirteen studies evaluated HbA1c variability among patients with type 2 diabetes. Higher HbA1c variability was associated with higher risk of renal disease (1.34 [1.15–1.57], two studies), macrovascular events (1.21 [1.06–1.38]), ulceration/gangrene (1.50 [1.06–2.12]), cardiovascular disease (1.27 [1.15–1.40]), and mortality (1.34 [1.18–1.53]). Most studies were retrospective with lack of adjustment for potential confounders, and inconsistency existed in the definition of HbA1c variability. CONCLUSIONS: HbA1c variability was positively associated with micro- and macrovascular complications and mortality independently of the HbA1c level and might play a future role in clinical risk assessment

'20 days protected learning' - students' experiences of an Overseas Nurses Programme - 4 years on: A retrospective survey

Background From September 2005 the Nursing and Midwifery Council (NMC) introduced new arrangements for the registration of non-EU overseas nurses which requires all applicants to undertake '20 days of protected learning' time in the UK and for some, a period of supervised practice. A survey was undertaken at Bournemouth University, which offers a '20 days protected learning only' programme, to elicit overseas nurses' demographic details, experiences in completing the programme and their 'final destinations' once registered. Methods An online survey was devised which contained a mixture of tick box and open ended questions which covered demographic details, views on the programme and final destinations This was uploaded to www.SurveyMonkey.com and sent out to nurses who had completed the Overseas Nurses Programme (ONP) with Bournemouth University (n=1050). Quantiative data were analysed using descriptive statistics and the qualitative data were coded and analysed using content analysis . Results There were 251 respondents (27.7% response rate). The typical 'profile' of a nurse who responded to the survey was female, aged 25-40 years and had been qualified for more than 5 years with a bachelors degree. The majority came from Australia on a 2 year working holiday visa and the key final destination in the UK, on registration with the NMC, was working for an agency. There were five key findings regarding experience of the programe. Of those surveyed 61.2% did not feel it necessary to undergo an ONP; 71.6% felt that they should be able to complete the programme on-line in their own country; 64.2% that the ONP should only contain information about delivery of healthcare in UK and Legal and professional (NMC) issues; 57% that European nurses should also undergo the same programme and sit an IELTS test; and 68.2% that the programme was too theory orientated; and should have links to practice (21%). Conclusions The NMC set the admissions criteria for entry to the register and Standards for an ONP. The findings of this survey raise issues regarding the percieved value and use of this approach for overseas nurses, and it may be helpful to take this into account when considering future policy