15 research outputs found
Site-selective benzoin-type cyclization of unsymmetrical dialdoses catalyzed by N-heterocyclic carbenes for divergent cyclitol synthesis
A highly site-selective N-heterocyclic carbene (NHC)-catalyzed benzoin-type cyclization of unsymmetrical dialdoses is developed to enable a divergent cyclitol synthesis. The choice of chiral NHCs and protecting groups affects the site-selectivity. The resulting inososes are converted into epi-, muco- and myo-inositol, and their chiral protected derivatives are formed in good yields
Catalytic Alkyne Arylation Using Amines as Traceless Directing Groups
By developing a
Pd(0)/Mandyphos catalyst, we have achieved a three-component aminoarylation of
alkynes to generate enamines, which upon hydrolysis yield either α-arylphenones or α,α-diarylketones. This
Pd-catalyzed method overcomes well-established pathways to enable the use of
amines as traceless directing groups for CâC bond formation
Catalytic Alkyne Arylation Using Traceless Directing Groups
By using Pd0/Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for CâC bond formation. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinhe
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Catalytic Alkyne Arylation Using Traceless Directing Groups
By using Pd0 /Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C-C bond formation
Catalytic Alkyne Arylation Using Amines as Traceless Directing Groups
By developing a
Pd(0)/Mandyphos catalyst, we have achieved a three-component aminoarylation of
alkynes to generate enamines, which upon hydrolysis yield either <i>α</i>-arylphenones or <i>α</i>,<i>α</i>-diarylketones. This
Pd-catalyzed method overcomes well-established pathways to enable the use of
amines as traceless directing groups for CâC bond formation
Ligand-Dependant Selective Synthesis of Mono- and Dialkenylcarbazoles through Rhodium(III)-Catalyzed C-H Alkenylation
Chemistry - An Asian Journal. 2023, 18 (4), P.e20220121
Mild Organic Base-Catalyzed Primary Alcohol-Selective Aroylation Reaction Using N-Aroylcarbazoles for Underexplored Prodrugs
We report a highly primary alcohol-selective aroylation reaction using N-aroylcarbazoles (NAroCs). The aroylationproceeded smoothly in the presence of DBU, which most likely works as a general base catalyst in the reaction system. The synthetic utility was displayed in the primary alcohol-selective aroylation of complex drug molecules and natural products to their prodrugs. Stoichiometrically generated carbazole, the starting material of NAroCs could be easily recovered. We also established safer multigram and multidecagram scale preparation methods of NAroCs, which are easy-to-handle bench-stable reagents.</div