You Call that Perpetual? Issues in Perpetual Access

Ensuring perpetual access to electronic resources is a difficult and multifaceted process. Many issues stand in the way of seamless ongoing access and challenge traditional definitions of “perpetual.” License agreements are often vague on the issue. Librarians and vendors often fail to properly track the content to which an institution is entitled after a contract has lapsed. New e-book editions complicate access to previous editions. Multimedia resources may rely on quickly outdated software, so that they become unusable even if the content still has value. These challenges, as well as strategies for working through them, are discussed in relation to electronic journals, books, and multimedia resources

Metabolic heterogeneity and the roles of CodY and CcpA in central metabolism and S. aureus biofilm formation.

Staphylococcus aureus is a metabolically versatile human pathogen, causing disease in many areas of the body. Its versatility can be attributed to the fact that it utilizes a variety of tools to adapt to many different environments, including toxins to scavenge from the host and multiple transporters to compete for its preferred carbon sources. S. aureus can also survive in harsh conditions through biofilm development, which are notoriously recalcitrant to antibiotics and immune defenses. Biofilms exhibit marked heterogeneity, with division of labor for production of matrix components and differential gene expression among various niches within the biofilm. In this study, we investigated the development of metabolic heterogeneity as structures form during biofilm maturation. Additionally, we investigated how metabolic regulators control proper development of mature structures and their impact on biofilm matrix composition. We observed the initiation of metabolic heterogeneity before nutrient gradients could form within structures, consistent with recent findings that heterogeneity is a trait that begins from the first stages of biofilm development, when cells encounter a surface. Furthermore, we observed inactivation of CodY and CcpA have a substantial impact on central carbon and nitrogen metabolism as well as toxin production and biofilm development

Discovery on a Budget: Improved Searching Without a Web-Scale Discovery Product

Discovery is a key component of a library\u27s services, and user expectation are high. Even if a Web-scale discovery system is not in the cards, there is plenty a library can do to improve discovery for their users. Librarians at Southern Illinois University Edwardsville have conducted a series of user studies focused on discovery tasks using the library\u27s website and catalog. The lessons learned fro these studies have led to an ongoing redesign of the library\u27s web-site as well as recommendations for instruction. This paper shares successful strategies for evaluating and improving discovery, no expensive software or programming skills necessary

OA in the Library Collection: The Challenges of Identifying and Maintaining Open Access Resources

While librarians, researchers, and the general public have embraced the concept of Open Access (OA), librarians still have a difficult time managing OA resources. To find out why, Bulock and Hosburgh surveyed librarians about their experiences managing OA resources and the strengths and weaknesses of management systems. At this session, they shared survey results, reflected on OA workflows at their own libraries, and updated audience members on relevant standards and initiatives. Survey respondents reported challenges related to hybrid OA, inaccurate metadata, and inconsistent communication along the serials supply chain. Recommended solutions included the creation of consistent, centralized article-level metadata and the development of OA collection development principles for libraries

Open access in the world of scholarly journals: creation and discovery

Sherpa Romeo green journal. This is an accepted manuscript of an article published by Taylor & Francis in The Serials Librarian, available online: http://www.tandfonline.com/10.1080/0361526X.2017.1309845Open Access publishing continues to grow, and it has profound implications for librarians in a variety of contexts. This report serves two functions. It provides background on Open Access publication of scholarly journals and the role of academic libraries in this movement. In particular, it examines the University of Lethbridge Journal Incubator as an example of library involvement in Open Access publication. The report also examines how hybrid journals, in an attempt to provide Open Access publication options in traditional subscription journals, have introduced a new discovery and access problem for libraries. While standards bodies have begun to address the problem, there are still many challenges when accessing open content in hybrid journalsYe

Implementing Behavior Analysis and Intervention for Individuals with Cognitive Impairments in Skilled Nursing Facilities: Summary of Results

Summary of Purpose The purpose of the project was to provide behavioral consultation and services to aging persons with cognitive impairment at skilled nursing facilities in Michigan. The goal was to use empirically supported non-pharmacological approaches to reduce behavioral and psychological symptoms of dementia (BPSD; wandering, agitation, disruptive vocalizations, etc.) and help slow down or remediate lost skills, reduce the use of medication to manage BPSD, to improve staff knowledge and abilities, and to develop modules that can be adopted and used by other skilled nursing facilities.The project was led by Dr. Janet Hahn, a social gerontologist with extensive experience studying nursing home culture change and the quality of long-term care services. The intervention project team consisted of doctoral, masters and undergraduate level behavior analysts with advanced training in working with aging populations, under the direction of Dr. Jonathan Baker (doctoral level board certified behavior analyst and behavioral gerontologist). The project was funded by the Civil Money Penalties fund of the Michigan Department of Health and Human Services from May 2016 and to April 2019. The project was conducted with oversight by the Western Michigan University Human Subjects Institutional Review Board, under approved protocol HSIRB Project Number 16-09-07, titled Implementing Behavior Analysis and Intervention for Individuals with Cognitive Impairment in Skilled Nursing Facilities

Relationship between a Weighted Multi-Gene Algorithm and Blood Pressure Control in Hypertension

Hypertension (HTN) is a complex disease with interactions among multiple organ systems, including the heart, vasculature, and kidney with a strong heritable component. Despite the multifactorial nature of HTN, no clinical guidelines utilize a multi-gene approach to guide blood pressure (BP) therapy. Non-smokers with a family history of HTN were included in the analysis (n = 384; age = 61.0 ± 0.9, 11% non-white). A total of 17 functional genotypes were weighted according to the previous effect size in the literature and entered into an algorithm. Pharmacotherapy was ranked from 1⁻4 as most to least likely to respond based on the algorithmic assessment of individual patient's genotypes. Three-years of data were assessed at six-month intervals for BP and medication history. There was no difference in BP at diagnosis between groups matching the top drug recommendation using the multi-gene weighted algorithm (n = 92) vs. those who did not match (n = 292). However, from diagnosis to nadir, patients who matched the primary recommendation had a significantly greater drop in BP when compared to patients who did not. Further, the difference between diagnosis to current 1-year average BP was lower in the group that matched the top recommendation. These data suggest an association between a weighted multi-gene algorithm on the BP response to pharmacotherapy.Geneticure Inc.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

An explanation for the interaction mechanism of an anionic polymeric additive on yeast flocculent cells

Magna Floc LT25 is a high molecular weight anionic polymer that has been described as increasing reaction rates inside flocs of yeast cells. However, no clear indication has been given on how this anionic polymer interacts with flocculent cells. Flocculation experiments made with a strain ofSaccharomyces cerevisiae corroborate that it bridges calcium ions bound to flocculent yeast cell walls, thus enlarging the available flux area for the transport of solutes inside the flocs

Analysis of substrate binding in individual active sites of bifunctional human ATIC

Aminoimidazolecarboxamide ribonucleotide formyl transferase (AICARFT): Inosine monophosphate cyclohydrolase (IMPCH, collectively called ATIC) is a bifunctional enzyme that catalyses the penultimate and final steps in the purine de novo biosynthesis pathway. The bifunctional protein is dimeric and each monomer contains two different active sites both of which are capable of binding nucleotide substrates, this means to a potential total of four distinct binding events might be observed. Within this work we used a combination of site-directed and truncation mutants of ATIC to independently investigate the binding at these two sites using calorimetry. A single S10W mutation is sufficient to block the IMPCH active site allowing investigation of the effects of mutation on ligand binding in the AICARFT active site. The majority of nucleotide ligands bind selectively at one of the two active sites with the exception of xanthosine monophosphate, XMP, which, in addition to binding in both AICARFT and IMPCH active sites, shows evidence for cooperative binding with communication between symmetrically-related active sites in the two IMPCH domains. The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study