The Design and Construction of Public Service Building in Developing Rural Regions During the Post COVID-19 Period: Cased on a Chinese Village Centre

The spread of COVID-19 has caused an increasing demand for public medical room. Cases of Chinese Huoshenshan Hospital and mobile cabin hospitals proved the effectiveness of constructing emergent medical buildings. However, these cases, usually with strict requirements on technology and infrastructure, are hard to implement in developing rural regions. Therefore, there is an urgent need for adapting industrial construction to the rural situation. This research introduced an adaptive approach for rural projects delivery during COVID-19. It is based on a longitudinal case study, recording and analysing the construction process of a village centre in Jiangsu, China, from 2019 to 2020. By comparing the construction process of actual operation and traditional method, the advantages in a shorter building period and lower labour density were verified. This research pointed out neglected risks in developing countries and provided a practical construction approach in these areas. It supported the prevention of COVID-19 global wide

Vibrational energy relaxation in proteins

An overview of theories related to vibrational energy relaxation (VER) in proteins is presented. VER of a selected mode in cytochrome c is studied using two theoretical approaches. One is the equilibrium simulation approach with quantum correction factors, and the other is the reduced model approach which describes the protein as an ensemble of normal modes interacting through nonlinear coupling elements. Both methods result in estimates of the VER time (sub ps) for a CD stretching mode in the protein at room temperature. The theoretical predictions are in accord with the experimental data of Romesberg's group. A perspective on future directions for the detailed study of time scales and mechanisms for VER in proteins is presented.Comment: 12 pages, 4 figures, accepted for publication in PNA

Experimental study on the supercritical startup of cryogenic loop heat pipes with redundancy design

Cryogenic loop heat pipe (CLHP) is one of the key components in the future space infrared exploration system, which enables effective and efficient cryogenic heat transport over a long distance with a flexible thermal link. To realize reliable and long life operation, a CLHP-based thermal control system with redundancy design was proposed in this work, where two nitrogen-charged CLHPs were employed to provide cryocooling at 80–100 K. This study focused on the supercritical startup of the CLHPs with redundancy design, and an extensive experimental study under four possible working modes was conducted. Experimental results showed that with 2.5 W applied to the secondary evaporator, each CLHP could realize the supercritical startup successfully in the normal working mode; however, the required time differed a lot because the difference in the transport line diameter significantly affected the cryocooling capacity to the primary evaporator. In the backup conversion mode, instant switch of the two primary evaporators may cause an operation failure, and an auxiliary operation of the secondary evaporator in advance was necessary to make the primary liquid line filled with liquid. In the malfunction conversion mode, the simulated infrared detector had to be first shut down, but the time needed for the backup CLHP to realize the supercritical startup became obviously shorter than that in the normal working mode, because the primary evaporator of the backup CLHP was always in a cryogenic state. In the dual operation mode, the two CLHPs could realize the supercritical startup simultaneously, but a temperature oscillation phenomenon was observed, which can be eliminated by increasing the heat load applied to the secondary evaporator

Exciton entanglement in two coupled semiconductor microcrystallites

Entanglement of the excitonic states in the system of two coupled semiconductor microcrystallites, whose sizes are much larger than the Bohr radius of exciton in bulk semiconductor but smaller than the relevant optical wavelength, is quantified in terms of the entropy of entanglement. It is observed that the nonlinear interaction between excitons increases the maximum values of the entropy of the entanglement more than that of the linear coupling model. Therefore, a system of two coupled microcrystallites can be used as a good source of entanglement with fixed exciton number. The relationship between the entropy of the entanglement and the population imbalance of two microcrystallites is numerically shown and the uppermost envelope function for them is estimated by applying the Jaynes principle.Comment: 16 pages, 6 figure

Stochastic Budget Optimization in Internet Advertising

Internet advertising is a sophisticated game in which the many advertisers "play" to optimize their return on investment. There are many "targets" for the advertisements, and each "target" has a collection of games with a potentially different set of players involved. In this paper, we study the problem of how advertisers allocate their budget across these "targets". In particular, we focus on formulating their best response strategy as an optimization problem. Advertisers have a set of keywords ("targets") and some stochastic information about the future, namely a probability distribution over scenarios of cost vs click combinations. This summarizes the potential states of the world assuming that the strategies of other players are fixed. Then, the best response can be abstracted as stochastic budget optimization problems to figure out how to spread a given budget across these keywords to maximize the expected number of clicks. We present the first known non-trivial poly-logarithmic approximation for these problems as well as the first known hardness results of getting better than logarithmic approximation ratios in the various parameters involved. We also identify several special cases of these problems of practical interest, such as with fixed number of scenarios or with polynomial-sized parameters related to cost, which are solvable either in polynomial time or with improved approximation ratios. Stochastic budget optimization with scenarios has sophisticated technical structure. Our approximation and hardness results come from relating these problems to a special type of (0/1, bipartite) quadratic programs inherent in them. Our research answers some open problems raised by the authors in (Stochastic Models for Budget Optimization in Search-Based Advertising, Algorithmica, 58 (4), 1022-1044, 2010).Comment: FINAL versio

The effect of e-cigarettes on smoking cessation and cigarette smoking initiation: An evidence-based rapid review and meta-analysis.

The contribution made by e-cigarettes to smoking cessation continues to be controversial. Reports suggest that teenagers are becoming increasingly addicted to e-cigarettes and that e-cigarette use in adolescents is associated with subsequent cigarette smoking. Systematic searches of eleven databases were conducted (January 2015 to June 2020). Systematic reviews, randomized controlled trials (RCTs) and cohort studies comparing e-cigarettes with placebo e-cigarettes, nicotine replacement therapy (NRT) or no e-cigarette use were included. The two primary outcomes were smoking cessation among smokers and smoking initiation among non-smoking teenagers. The secondary outcome was adverse events. Data were synthesized using risk ratio (RR) or adjusted odds ratio (AOR) with 95% confidence interval (CI). Six systematic reviews, 5 RCTs and 24 cohort studies were identified. For smoking cessation, findings from 4 systematic reviews indicated that e-cigarettes contributed to cessation while one found the opposite. Meta-analysis of 5 RCTs suggested that e-cigarettes were superior to NRT or placebo for smoking cessation (RR=1.55; 95% CI: 1.00-2.40; I =57.6%; low certainty; 5 trials, n=4025). Evidence from 9 cohort studies showed that e-cigarette use was not associated with cessation (AOR=1.16; 95% CI: 0.88-1.54; I =69.0%; n=22220). Subgroup analysis suggested that intensive e-cigarette use may be associated with cessation. In terms of smoking initiation, adolescents who ever used e-cigarettes had a greater risk for smoking initiation than non-users (AOR=2.91; 95% CI: 2.61-3.23; I =61.0%; 15 trials, n=68943), the findings were consistent with one included systematic review. No serious adverse events were reported in the included studies. Low certainty evidence suggests that e-cigarettes appear to be potentially effective for smoking cessation. The use of e-cigarettes in adolescents may be associated with smoking initiation. No serious adverse events were reported. [Abstract copyright: © 2021 Zhang Y.Y. et al.

Scalar field propagation in the phi^4 kappa-Minkowski model

In this article we use the noncommutative (NC) kappa-Minkowski phi^4 model based on the kappa-deformed star product, ({*}_h). The action is modified by expanding up to linear order in the kappa-deformation parameter a, producing an effective model on commutative spacetime. For the computation of the tadpole diagram contributions to the scalar field propagation/self-energy, we anticipate that statistics on the kappa-Minkowski is specifically kappa-deformed. Thus our prescription in fact represents hybrid approach between standard quantum field theory (QFT) and NCQFT on the kappa-deformed Minkowski spacetime, resulting in a kappa-effective model. The propagation is analyzed in the framework of the two-point Green's function for low, intermediate, and for the Planckian propagation energies, respectively. Semiclassical/hybrid behavior of the first order quantum correction do show up due to the kappa-deformed momentum conservation law. For low energies, the dependence of the tadpole contribution on the deformation parameter a drops out completely, while for Planckian energies, it tends to a fixed finite value. The mass term of the scalar field is shifted and these shifts are very different at different propagation energies. At the Planckian energies we obtain the direction dependent kappa-modified dispersion relations. Thus our kappa-effective model for the massive scalar field shows a birefringence effect.Comment: 23 pages, 2 figures; To be published in JHEP. Minor typos corrected. Shorter version of the paper arXiv:1107.236

Polo-like kinase 1 siRNA-607 induces mitotic arrest and apoptosis in human nasopharyngeal carcinoma cells

Polo-like kinase (Plk) 1 is overexpressed in many human malignancies including nasopharyngeal carcinoma, indicating its potential as a therapeutic target. Recently, using a simple cellular morphologybased strategy, we have identified several novel effective siRNAs against Plk1 including Plk1 siRNA- 607. In this study, we further investigated the effects of Plk1 siRNA-607 in human nasopharyngeal carcinoma cell line, HNE-1. Real time RT-PCR and Western blot indicated that Plk1 siRNA-607 transfection resulted in a significant inhibition in Plk1 expression in the HNE-1 cells. Furthermore, cell cycle, cell growth and apoptosis analysis clearly indicated that Plk1 siRNA-607 caused a dramatic mitotic cell cycle arrest followed by massive apoptotic cell death, and eventually resulted in a significant decrease in growth and viability of the nasopharyngeal carcinoma cells. Given that Plk1 has been widely accepted as a novel efficient target for cancer therapy, these results suggested that Plk1 siRNA-607 could be further developed for the treatment of human nasopharyngeal carcinoma.Key words: Nasopharyngeal carcinoma, Plk1, RNA silencing, cell cycle, apoptosis