Irresponsible contagions: Propagating harmful behavior through imitation

‘Monkey see, monkey do’ is an old saying referring to imitating another\u27s actions without necessarily understanding the underlying motivations or being concerned about consequences, such as propagating harmful behaviors. This study examines the likelihood of firms imitating and proliferating others’ unethical, irresponsible practices thereby exacerbating harmful effects among even more firms; in doing so, irresponsible contagions can rapidly spread more broadly, negatively affecting even more consumers. Building upon rivalry- and information-based imitation theories, we examine if harmful behaviors of others, in combination with misbehavior of referent firms, influences the likelihood of a firm to engage in irresponsible consumer-related practices. After examining 25,824 firm-year observations over 12 years, our findings suggest that imitation of harmful product-related behavior occurs; with size an important factor related to proliferation of harmful behaviors. Testing the model against a holdout sample finds 94% accuracy. Implications for scholars, managers, and policy makers are explored

Here Today, Gone Tomorrow: Understanding Freshman Attrition Using Person-Environment Fit Theory

Person-Environment (PE) fit theory was used to explore the relationship between student involvement and freshman retention. Incoming freshmen (N=382) were followed longitudinally in a twowave panel study, the summer before beginning college, and again during the spring of their freshman year. Involvement levels, a variety of summer and spring preferences (Ps), and spring perceptions (Es) regarding specific aspects of their college environment were assessed. Twelve PE fit indicators were derived and compared with respect to their relationship with student involvement and retention. Results indicated that involvement was linked to some PE fit indicators. Traditional parametric statistical analyses were compared with a new, nonparametric technique, Classification Tree Analysis (CTA), to identify the most accurate classification model for use in designing potential attrition interventions. Discriminant analysis was 14% more accurate than CTA in classifying returners (97% vs. 85%), but CTA was 962% more accurate classifying dropouts (8% vs. 84%). CTA identified nine clusters— five of returners and four of dropouts, revealing that different subgroups of freshmen chose to return (and stay) for different reasons. Students’ end-of-the-year preferences appear to be more important than anticipated preferences, college perceptions, or PE fit level

Savoring the moment: A link between affectivity and depression

Objective: Positive affectivity (PA; disposition to experience positive moods) and negative affectivity (NA; disposition to experience negative moods) may be risk factors for depression. Low PA may impair positive emotion regulation (savoring), potentially exacerbating depression. Understanding the mechanisms in which temporal domains of savoring influence the relationship between affectivity and depression may help advance depression treatments.Method: 1,618 participants (1,243 females; 70.0% Caucasian, 19.1% Asian, 4.5% African American, 0.9% Pacific Islander, 0.7% American Indian or Alaskan Native, 4.9% Biracial) ages 17 - 40 (M = 18.99, SD = 1.33) completed questionnaires. An exploratory path analysis was run with PA and NA as exogenous variables, savoring domains as mediators, and depression the outcome.Results: PA and NA were associated with depression and all three savoring temporal domains. Momentary savoring distinctly mediated the relationship between both PA and NA and depression.Limitations: The data are self-report and cross-sectional, precluding causal inference. Post-hoc power analysis indicated that the present study was underpowered. The use of a college sample primarily comprised of Caucasian women limits generalizability.Conclusions: Affectivity was associated with the temporal domains of savoring and indirectly associated with depression via momentary savoring. All temporal domains of savoring may bolster PA and mitigate NA. Momentary savoring may reduce depression symptoms in individuals with low PA and high NA

Highly conserved molecular pathways, including Wnt signaling, promote functional recovery from spinal cord injury in lampreys

© The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 8 (2018): 742, doi:10.1038/s41598-017-18757-1.In mammals, spinal cord injury (SCI) leads to dramatic losses in neurons and synaptic connections, and consequently function. Unlike mammals, lampreys are vertebrates that undergo spontaneous regeneration and achieve functional recovery after SCI. Therefore our goal was to determine the complete transcriptional responses that occur after SCI in lampreys and to identify deeply conserved pathways that promote regeneration. We performed RNA-Seq on lamprey spinal cord and brain throughout the course of functional recovery. We describe complex transcriptional responses in the injured spinal cord, and somewhat surprisingly, also in the brain. Transcriptional responses to SCI in lampreys included transcription factor networks that promote peripheral nerve regeneration in mammals such as Atf3 and Jun. Furthermore, a number of highly conserved axon guidance, extracellular matrix, and proliferation genes were also differentially expressed after SCI in lampreys. Strikingly, ~3% of differentially expressed transcripts belonged to the Wnt pathways. These included members of the Wnt and Frizzled gene families, and genes involved in downstream signaling. Pharmacological inhibition of Wnt signaling inhibited functional recovery, confirming a critical role for this pathway. These data indicate that molecular signals present in mammals are also involved in regeneration in lampreys, supporting translational relevance of the model.We gratefully acknowledge support from the National Institutes of Health (R03NS078519 to OB; R01GM104123 to JJS; R01NS078165 to JRM), The Feinstein Institute for Medical Research and The Marine Biological Laboratory, including the Charles Evans Foundation Research Award, the Albert and Ellen Grass Foundation Faculty Research Award, and The Eugene and Millicent Bell Fellowship Fund in Tissue Engineering

Acinar Cell Apoptosis in Serpini2-Deficient Mice Models Pancreatic Insufficiency

Pancreatic insufficiency (PI) when left untreated results in a state of malnutrition due to an inability to absorb nutrients. Frequently, PI is diagnosed as part of a larger clinical presentation in cystic fibrosis or Shwachman–Diamond syndrome. In this study, a mouse model for isolated exocrine PI was identified in a mouse line generated by a transgene insertion. The trait is inherited in an autosomal recessive pattern, and homozygous animals are growth retarded, have abnormal immunity, and have reduced life span. Mice with the disease locus, named pequeño (pq), exhibit progressive apoptosis of pancreatic acinar cells with severe exocrine acinar cell loss by 8 wk of age, while the islets and ductal tissue persist. The mutation in pq/pq mice results from a random transgene insertion. Molecular characterization of the transgene insertion site by fluorescent in situ hybridization and genomic deletion mapping identified an approximately 210-kb deletion on Chromosome 3, deleting two genes. One of these genes, Serpini2, encodes a protein that is a member of the serpin family of protease inhibitors. Reintroduction of only the Serpini2 gene by bacterial artificial chromosome transgenic complementation corrected the acinar cell defect as well as body weight and immune phenotypes, showing that deletion of Serpini2 causes the pequeño phenotype. Dietary supplementation of pancreatic enzymes also corrected body size, body weight, and immunodeficiency, and increased the life span of Serpini2-deficient mice, despite continued acinar cell loss. To our knowledge, this study describes the first characterized genetic animal model for isolated PI. Genetic complementation of the transgene insertion mutant demonstrates that Serpini2 deficiency directly results in the acinar cell apoptosis, malabsorption, and malnutrition observed in pq/pq mice. The rescue of growth retardation, immunodeficiency, and mortality by either Serpini2 bacterial artificial chromosome transgenic expression or by pancreatic enzyme supplementation demonstrates that these phenotypes are secondary to malnutrition in pq/pq mice

Society for Cardiovascular Magnetic Resonance (SCMR) guidance for the practice of cardiovascular magnetic resonance during the COVID-19 pandemic

The aim of this document is to provide general guidance and specific recommendations on the practice of cardiovascular magnetic resonance (CMR) in the era of the COVID-19 pandemic. There are two major considerations. First, continued urgent and semi-urgent care for the patients who have no known active COVID-19 should be provided in a safe manner for both patients and staff. Second, when necessary, CMR on patients with confirmed or suspected active COVID-19 should focus on the specific clinical question with an emphasis on myocardial function and tissue characterization while optimizing patient and staff safety