Bowley, Jennifer S

Bryant, Naomi J

Ohrling, Anu

Ross, Euan M

Verity, Christopher M

Ward, Katherine N

English

PubMed

Objective To determine the contribution of herpes simplex virus (HSV) to serious neurological disease. Setting and patients A 3-year prospective survey of children aged 2-23 months in Britain and Ireland. Results 19 children had HSV central nervous system (CNS) infection; 13 aged 2-11 months had focal neuroimaging abnormalities and 11 long-term neurological sequelae. Of six aged 12-35 months, one had abnormal neuroimaging and three long-term neurological sequelae. 17 of the 19 had serious neurological disease. HSV CNS infection accounted for 23% of serious neurological disease in children aged 2-11 months and 4.5% in older children. Conclusions The incidence of HSV-induced serious neurological disease in the UK was estimated at 1 in 64 000/year in younger children and 1 in 230 000 in older children. HSV CNS infection has clinical effects ranging from frank encephalitis to severe illness with fever and convulsions to milder disease lacking encephalopathy

Ward, Katherine N.

Bryant, Naomi J.

Bowley, Jennifer S.

Ross, Euan M.

Verity, Christopher M.

King's Research Portal

Herpes simplex serious neurological disease in young children: incidence and long-term outcome

Katherine N Ward

Anu Ohrling

Naomi J Bryant

Jennifer S Bowley

Euan M Ross

Christopher M Verity

Crossref

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3256733

Herpes simplex serious neurological disease in young children: incidence and long-term outcome

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