125 research outputs found
Hunting keV sterile neutrinos with KATRIN: Building the first TRISTAN module
The KATRIN (Karlsruhe Tritium Neutrino) experiment investigates the energetic endpoint of the tritium beta-decay spectrum to determine the effective mass of the electron anti-neutrino. The collaboration has reported a first mass measurement result at this TAUP-2019 conference. The TRISTAN project aims at detecting a keV-sterile neutrino signature by measuring the entire tritium beta-decay spectrum with an upgraded KATRIN system. One of the greatest challenges is to handle the high signal rates generated by the strong activity of the KATRIN tritium source while maintaining a good energy resolution. Therefore, a novel multi-pixel silicon drift detector and read-out system are being designed to handle rates of about 100 Mcps with an energy resolution better than 300 eV (FWHM). This report presents succinctly the KATRIN experiment, the TRISTAN project, then the results of the first 7-pixels prototype measurement campaign and finally describes the construction of the first TRISTAN module composed of 166 SDD-pixels as well as its implementation in KATRIN experiment
Neutron Decay Correlations in the Nab Experiment
The Nab experiment will measure the correlation a between the momenta of the beta particle and antineutrino in neutron decay as well as the Fierz term b which distorts the beta spectrum
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Improved Upper Limit on the Neutrino Mass from a Direct Kinematic Method by KATRIN.
We report on the neutrino mass measurement result from the first four-week science run of the Karlsruhe Tritium Neutrino experiment KATRIN in spring 2019. Beta-decay electrons from a high-purity gaseous molecular tritium source are energy analyzed by a high-resolution MAC-E filter. A fit of the integrated electron spectrum over a narrow interval around the kinematic end point at 18.57 keV gives an effective neutrino mass square value of (-1.0_{-1.1}^{+0.9})  eV^{2}. From this, we derive an upper limit of 1.1 eV (90% confidence level) on the absolute mass scale of neutrinos. This value coincides with the KATRIN sensitivity. It improves upon previous mass limits from kinematic measurements by almost a factor of 2 and provides model-independent input to cosmological studies of structure formation
Characterization of silicon drift detectors with electrons for the TRISTAN project
Sterile neutrinos are a minimal extension of the standard model of particle physics. A promising model-independent way to search for sterile neutrinos is via high-precision β-spectroscopy. The Karlsruhe tritium neutrino (KATRIN) experiment, equipped with a novel multi-pixel silicon drift detector focal plane array and read-out system, named the TRISTAN detector, has the potential to supersede the sensitivity of previous laboratory-based searches. In this work we present the characterization of the first silicon drift detector prototypes with electrons and we investigate the impact of uncertainties of the detector\u27s response to electrons on the final sterile neutrino sensitivity
Characterization of Silicon Drift Detectors with Electrons for the TRISTAN Project
Sterile neutrinos are a minimal extension of the Standard Model of Particle
Physics. A promising model-independent way to search for sterile neutrinos is
via high-precision beta spectroscopy. The Karlsruhe Tritium Neutrino (KATRIN)
experiment, equipped with a novel multi-pixel silicon drift detector focal
plane array and read-out system, named the TRISTAN detector, has the potential
to supersede the sensitivity of previous laboratory-based searches. In this
work we present the characterization of the first silicon drift detector
prototypes with electrons and we investigate the impact of uncertainties of the
detector's response to electrons on the final sterile neutrino sensitivity.Comment: 18 pages, 8 figures. J. Phys. G: Nucl. Part. Phys. 48 01500
Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization
Background
Asthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, the temporality and individual susceptibility to environmental epigenetic regulation of asthma has not been fully elucidated. Our objective was to determine the timeline of black carbon (BC) exposure, measured by personal sampling, on DNA methylation of allergic asthma genes 5 days later to capture usual weather variations and differences related to changes in behavior and activities. We also sought to determine how methylation may vary by seroatopy and cockroach sensitization and by elevated fractional exhaled nitric oxide (FeNO).
Methods
Personal BC levels were measured during two 24-h periods over a 6-day sampling period in 163 New York City children (age 9–14 years), repeated 6 months later. During home visits, buccal cells were collected as noninvasive surrogates for lower airway epithelial cells and FeNO measured as an indicator of airway inflammation. CpG promoter loci of allergic asthma genes (e.g., interleukin 4 (IL4), interferon gamma (IFNγ), inducible nitric oxide synthase (NOS2A)), arginase 2 (ARG2)) were pyrosequenced at the start and end of each sampling period.
Results
Higher levels of BC were associated with lower methylation of IL4 promoter CpG−48 5 days later. The magnitude of association between BC exposure and demethylation of IL4 CpG−48 and NOS2A CpG+5099 measured 5 days later appeared to be greater among seroatopic children, especially those sensitized to cockroach allergens (RR [95% CI] 0.55 [0.37–0.82] and 0.67 [0.45–0.98] for IL4 CpG−48 and NOS2A CpG+5099, respectively), compared to non-sensitized children (RR [95% CI] 0.87 [0.65–1.17] and 0.95 [0.69–1.33] for IL4 CpG−48 and NOS2A CpG+5099, respectively); however, the difference was not statistically different. In multivariable linear regression models, lower DNA methylation of IL4 CpG−48 and NOS2A CpG+5099 were associated with increased FeNO.
Conclusions
Our results suggest that exposure to BC may exert asthma proinflammatory gene demethylation 5 days later that in turn may link to airway inflammation. Our results further suggest that seroatopic children, especially those sensitized to cockroach allergens, may be more susceptible to the effect of acute BC exposure on epigenetic changes
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