613 research outputs found
Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases.
Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids. We here assessed their in vitro effects upon 5-, 12-, 15-LOX and COX-1 enzymes as well as NFκB activation in intact cells as their possible therapeutic targets. All methanol crude extracts inhibited both 5-LOX and COX-1 activities under 200 µg/mL, without significant effects on the 12-LOX pathway or any relevant in vitro free radical scavenging activity. NFκB activation was prevented by all extracts but A. mollis. Interestingly, A. ligustica, A. arborescens and A. mollis increased the biosynthesis of 15(S)-HETE, an anti-inflammatory eicosanoid. A. ligustica (IC50 =49.5 µg/mL) was superior to Silybum marianum (IC50 =147.8 µg/mL), which we used as antipsoriatic herbal medicine of reference. Its n-hexane, dichloromethane and ethyl acetate fractions had also inhibitory effects on the LTB4 biosynthesis (IC50 s=9.6, 20.3 and 68 µg/mL, respectively) evidencing that the apolar extracts of A. ligustica are promising active herbal ingredients for future phytotherapeutical products targeting psoriasis
External Reactor Vessel Cooling Evaluation for Severe Accident Mitigation in NPP Krško
The In-Vessel corium Retention (IVR) through the External Reactor Vessel Cooling (ERVC)
is mean for maintaining the reactor vessel integrity during a severe accident, by cooling and retaining
the molten material inside the reactor vessel. By doing this, significant portion of severe accident
negative phenomena connected with reactor vessel failure could be avoided.
In this paper, analysis of NPP Krško applicability for IVR strategy was performed. It includes
overview of performed plant related analysis with emphasis on wet cavity modification, plant’s site
specific walk downs, new applicable probabilistic and deterministic analysis, evaluation of new
possibilities for ERVC strategy implementation regarding plant’s post-Fukushima improvements and
adequacy with plant’s procedures for severe accident mitigation.
Conclusion is that NPP Krško could perform in-vessel core retention by applying external
reactor vessel cooling strategy with reasonable confidence in success. Per probabilistic and
deterministic analysis, time window for successful ERVC strategy performance for most dominating
plant damage state scenarios is 2.5 hours, when onset of core damage is observed. This action should
be performed early after transition to Severe Accident Management Guidance’s (SAMG). For loss
of all AC power scenario, containment flooding could be initiated before onset of core damage within
related emergency procedure. To perform external reactor vessel cooling, reactor water storage tank
gravity drain with addition of alternate water is needed to be injected into the containment. ERVC
strategy will positively interfere with other severe accident strategies. There are no negative effects
due to ERVC performance. New flooding level will not threaten equipment and instrumentation
needed for long term SAMGs performance and eventually diluted containment sump borated water
inventory will not cause return to criticality during eventual recirculation phase due to the lost core
geometry
Biochar and sewage sludge phosphorus fertilizer effects on phosphorus bioavailability and spinach ( Spinacia oleracea L.) yields under no-till system in semi-arid soils
Purpose This field study evaluated the interactive effects of biochar (BC) and sewage sludge (SS) on P bioavailability and spinach yields for two seasons.Method Treatments were combinations of biochar (0, 2.5 and 5 Mg ha-1) and sewage sludge (0, 6 and 12 Mg ha-1), or mineral fertilizer (200, 28, and 18.9 kg ha-1), amended in a randomized complete block design to Luvisol and Cambisol.Results Significant (p 0.05) yields compared to sole amendments. Mehlich – 3 extractable P (M3-P) in control plots (CONT) increased between seasons, presumably due to P inputs from the irrigation water. Co-amendments on the Cambisol resulted in higher M3-P increase over mineral fertilizer than on the Luvisol in both seasons. Accumulation of M3-P in control plots confounded correlations between crop yields and available P. Higher P under BC compared to SS amended soils emphasize biochar capacity to capture P from irrigation water.Conclusion The results suggest that combined low rates of SS and BC can have significant effects on P availability and crop yields. Biochar enhanced plant P uptake, but decrease in yields with simultaneous increase in M3-P between seasons warrants further research
Effects of softwood biochars on soil biota in medium-term field experiments in Finland
Biochar soil amendment could be used to sequester carbon, enhance soil fertility and potentially increase crop yields. It can have significant impacts on soil organic carbon levels and physicochemical conditions, which consequently affect soil micro- and macro-biota. It is therefore important to understand how key biological components in the soil such as microbial and earthworm communities response to biochar application in the long-term. This study was conducted in Southern Finland in a fertile Stagnosol and a nutrient deficient Umbrisol, four and five years after biochar amendment, respectively. Biochars were produced from spruce (Picea abies (L.) H.Karst.) and pine (Pinus sylvestris L.), and applied at the rates of 10 and 30 t ha-1, respectively. Earthworms and soil samples for microbial analyses were collected in September 2015. Soil microbial communities were studied by using phospholipid fatty acid profiling and 16S rRNA gene amplicon sequencing. Casts from the sampled earthworms were collected to investigate the consumption of biochar and the potential of earthworm bioturbation to affect biochar distribution. Additionally, greenhouse gas emissions from soil were measured. Biochar and fertilizer treatments or their interaction had no statistically significant effects on the earthworm abundance, community composition or greenhouse gas emissions in either field. Earthworms had ingested biochar as earthworm casts from biochar treated-plots contained significantly more black carbon than those in the control plots, demonstrating that earthworm bioturbation is a potentially important factor in the translocation of applied biochar in the soil profile. Microbial community structure data will be presented in the final presentation.Non peer reviewe
CABLE AGING MANAGEMENT AS PART OF THE EXTENDED NUCLEAR POWER PLANT LIFESPAN PROGRAMME
Članak daje sveobuhvatan pregled procesa starenja kabela, od identifikacije mehanizama i procjene starenja te učinka na sigurnost nuklearnih elektrana do upravljanja samim procesom. Cilj je zaokružiti temu iz različitih perspektiva i dati informacije i zaključke utemeljene na iskustvu i pouzdanim rezultatima mjerenja.The article provides a comprehensive overview of the cable aging process, from mechanism identification and aging assessment and the effect on nuclear power plants’ safety to the management of the process itself. The objective is to round up the subject from different perspectives and provide information and conclusions based on experience and reliable measurement results
Comparison between Stereo Optical Strain Measurements and Finite Element Results in Stress Concentration Zones
Experimental testing and deformation measurements during static loading in areas with high gradients are usually accompanied by uncertainties and inaccuracies of the applied methods. Comparison between different experimentally determined deformations and numerical calculation results of deformations at the determined measured points could be used to determine sensitivities and suitability of the particular measurement method for small deformations and pronounced levels of plastification. The paper presents analysis of combined deformation measurement methods with strain gauges and stereo-optical methods near the fatigue crack on the specimen during tensile loading. The results show that strain gauges are suitable for measurements at smaller deformations as applied for monitoring deformations during fatigue crack propagation. The stereo optical methods are suitable for measurements when significant elastic deformations occur, i.e. near the yield point, during static testing with plastic deformations and material fracture
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