15 research outputs found

    ‘Transatlantic connection’: K-pop and K-drama fandom in Spain and Latin America

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    The global circulation of Asian cultural products has been on a constant rise since the 1990s. However, the arrival to Spanish-speaking audiences is a more recent phenomenon, one that is linked to the consolidation of web-based tools for consumption, distribution and discussion of cultural artefacts. The different stages in which Hallyu, or the ‘Korean Wave’, reached different countries determined the intensity of scholarly interest in the phenomenon. If the research gap between Asia and Europe is wide, the later arrival to Spain and Latin America means that studies on the reception of Korean popular culture, including those dealing with fandom, are quasi-non-existent. This article is a first attempt at mapping the demographics of K-pop and K-drama fans in the Spanish-speaking world, through an analysis of an online survey. Drawing from the uses and gratifications approach in mass communication research, we discuss fans’ appropriation of K-pop, describe their shared iconography and analyse the peculiarities of male fans by studying their self-narratives. We conclude with a discussion on the need for studies of fandom to transcend national boundaries as exemplified by the advent of a ‘transatlantic connection’ linking fans in Spain and in Latin America via South Korea

    Reducing Pain and Improving Quality of Life for Patients Suffering the Acetabular Fracture

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    The rationale for this paper was to find out assessment tools and relevant factors that may reduce pain, and improve the quality of life and ability to perform activities of daily living in surgically and conservatively treated patients who sustained the acetabular fracture. One hundred and three patients with the acetabular injury were analysed during the 10-year retrospective case-control study. The case group consisted of 21 patients in whom the posterior acetabular wall was fractured and who were treated surgically. The control group comprised 82 patients with complex acetabular fracture in whom conservative treatment was applied. In order to assess post injury and postoperative quality of life different factors, such as the intensity and chronicity of pain, as well as the ability to resume activities of daily living, the patients were surveyed by anamnestic questionnaire to acquire the results. The quality of life was mostly better in patients from the case group who were operated on. At the follow-up, the features of pain were lower, management overall length shorter, and return to normal daily life activities faster in the surgically treated patients, compared to those who were not. In conclusion, based on our research we assume that surgery may notably decrease features of pain and improve the quality of life in patients with the acetabular injury

    Mutations in KEOPS-Complex Genes Cause Nephrotic Syndrome with Primary Microcephaly

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    Galloway-Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain anomalies. Here we identified recessive mutations in OSGEP, TP53RK, TPRKB, and LAGE3, genes encoding the four subunits of the KEOPS complex, in 37 individuals from 32 families with GAMOS. CRISPR-Cas9 knockout in zebrafish and mice recapitulated the human phenotype of primary microcephaly and resulted in early lethality. Knockdown of OSGEP, TP53RK, or TPRKB inhibited cell proliferation, which human mutations did not rescue. Furthermore, knockdown of these genes impaired protein translation, caused endoplasmic reticulum stress, activated DNA-damage-response signaling, and ultimately induced apoptosis. Knockdown of OSGEP or TP53RK induced defects in the actin cytoskeleton and decreased the migration rate of human podocytes, an established intermediate phenotype of SRNS. We thus identified four new monogenic causes of GAMOS, describe a link between KEOPS function and human disease, and delineate potential pathogenic mechanisms

    THE HOUSE OF BLACK AND WHITE: IDENTITIES OF COLOR AND POWER RELATIONS IN THE GAME OF THRONES

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    This article analyzes the representations of non-white identities in an HBO’s fantasy show “Game of Thrones” (GOT). By specifically focusing on hegemonic relations between white characters and characters of color, the research scrutinizes the rhetorical strategies through which non-whiteness is enacted in relation to white “natives” of the “Westeros.” Authors show that the GOT employs orientalist discourse in constructing the world of Westeros and contrasts it with the exotic lands of Essos. Westeros is rich, white and located in the western hemisphere, while Essos is a scorched and mysterious land located in the East. By associating the show’s major characters with Westeros and the casting of white actors, viewers are encouraged to identify with their complex struggles and to embrace their intricate characterizations. On the other hand, Essos’ characters of color typically include marginalized characters such as slaves, servants, and pirates. Their story arcs are glazed over and their characterization serves not to enhance the narrative but to emphasize the uniqueness of a superior cultural entity, i.e. Westeros. The essay discusses the implications in which GOT perpetuates long-established relations in a re-imagined system of power, which its writers and audiences have identified as female progressive and noted for its narrative complexity

    Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly

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    Interim 2017/18 influenza seasonal vaccine effectiveness: Combined results from five European studies

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    Alirocumab in patients with polyvascular disease and recent acute coronary syndrome ODYSSEY OUTCOMES trial

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    Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events The ODYSSEY OUTCOMES Trial

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    Alirocumab reduces total hospitalizations and increases days alive and out of hospital in the ODYSSEY OUTCOMES trial

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