Attractor Flows from Defect Lines

Deforming a two dimensional conformal field theory on one side of a trivial defect line gives rise to a defect separating the original theory from its deformation. The Casimir force between these defects and other defect lines or boundaries is used to construct flows on bulk moduli spaces of CFTs. It turns out, that these flows are constant reparametrizations of gradient flows of the g-functions of the chosen defect or boundary condition. The special flows associated to supersymmetric boundary conditions in N=(2,2) superconformal field theories agree with the attractor flows studied in the context of black holes in N=2 supergravity.Comment: 28 page

Detection loophole in asymmetric Bell experiments

The problem of closing the detection loophole with asymmetric systems is addressed. We show that, for the Bell inequality I_{3322}, a minimal detection efficiency of 43% can be tolerated for one of the particles, if the other one is always detected. Based on a connection between local hidden variable models exploiting the detection loophole and models using classical communication, we derive a lower bound on the necessary detection efficiency and show that some non-maximally entangled states cannot be simulated with one bit of communication. Furthermore we study the influence of noise and discuss the prospects of experimental implementation

QS-21 Adjuvant: Laboratory-Scale Purification Method and Formulation Into Liposomes.

QS-21, a saponin extracted from the tree Quillaja saponaria Molina, is a vaccine adjuvant which has been shown to elicit robust antibody and cell-mediated immune responses in a variety of preclinical and clinical studies [1]. Its purification from the natural source is a lengthy and difficult process. The commercially available saponin mixture Quil-A® is a fraction of the bark extract containing a variety of saponins, including QS-21. In order to facilitate access to QS-21 at laboratory-scale amounts, we propose here a method of purification of QS-21 starting from Quil-A®. In addition, we describe a protocol to appropriately formulate QS-21 into cholesterol-containing, neutral liposomes which are known to decrease QS-21's hemolytic activity while retaining the adjuvant effect. Methods for the physicochemical characterization of purified QS-21 and of the QS-21/liposome formulations are also described

Molecular beam epitaxy of high structural quality Bi2Se3 on lattice matched InP(111) substrates

Epitaxial layers of the topological insulator Bi2Se3 have been grown by molecular beam epitaxy on laterally lattice-matched InP(111)B substrates. High resolution X-ray diffraction shows a significant improvement of Bi2Se3 crystal quality compared to layers deposited on other substrates. The measured full width at half maximum of the rocking curve is Delta omega=13 arcsec, and the (omega-2theta) scans exhibit clear layer thickness fringes. Atomic force microscope images show triangular twin domains with sizes increasing with layer thickness. The structural quality of the domains is confirmed on the microscopic level by transmission electron microscopy.Comment: 4 pages, 4 figure

Definitions of severity in treatment seeking studies of febrile illness in children in low and middle income countries: a scoping review

Objectives: Understanding treatment seeking for severe febrile illness (SFI) is methodologically challenging. In this scoping review, we investigate definitions of severe febrile illness in treatment seeking studies on children under 5 years of age in low and middle income countries. We analyze the association of SFI definitions with different concepts of treatment seeking and identify related research gaps. Methods: We searched Pubmed, Scopus and WHOLIS, and screened references of included publications for eligibility. Results: Definitions of SFI had either a biomedical perspective (predominantly in quantitative studies) or a caregiver perspective (predominantly in qualitative studies). In quantitative analyses of treatment seeking, severity was more often conceptualized as a determinant rather than an outcome of a treatment seeking process. The majority of quantitative analyses only included surviving children or did not explicitly mention dead children. Conclusion: Different research questions lead to diverse definitions and concepts of severity and treatment seeking outcomes, which limits the comparability of the available evidence. Systematic exclusion of dead children is likely to bias inferences on the association of treatment seeking and health outcomes of children with SFI in low and middle income countries

Defect Perturbations in Landau-Ginzburg Models

Perturbations of B-type defects in Landau-Ginzburg models are considered. In particular, the effect of perturbations of defects on their fusion is analyzed in the framework of matrix factorizations. As an application, it is discussed how fusion with perturbed defects induces perturbations on boundary conditions. It is shown that in some classes of models all boundary perturbations can be obtained in this way. Moreover, a universal class of perturbed defects is constructed, whose fusion under certain conditions obey braid relations. The functors obtained by fusing these defects with boundary conditions are twist functors as introduced in the work of Seidel and Thomas.Comment: 46 page

Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

A comprehensive characterization of the lipidome from limited starting material remains very challenging. Here we report a high-sensitivity lipidomics workflow based on nanoflow liquid chromatography and trapped ion mobility spectrometry (TIMS). Taking advantage of parallel accumulation-serial fragmentation (PASEF), we fragment on average 15 precursors in each of 100 ms TIMS scans, while maintaining the full mobility resolution of co-eluting isomers. The acquisition speed of over 100 Hz allows us to obtain MS/MS spectra of the vast majority of isotope patterns. Analyzing 1 mu L of human plasma, PASEF increases the number of identified lipids more than three times over standard TIMS-MS/MS, achieving attomole sensitivity. Building on high intra- and inter-laboratory precision and accuracy of TIMS collisional cross sections (CCS), we compile 1856 lipid CCS values from plasma, liver and cancer cells. Our study establishes PASEF in lipid analysis and paves the way for sensitive, ion mobility-enhanced lipidomics in four dimensions

Integrability of the N=2 boundary sine-Gordon model

We construct a boundary Lagrangian for the N=2 supersymmetric sine-Gordon model which preserves (B-type) supersymmetry and integrability to all orders in the bulk coupling constant g. The supersymmetry constraint is expressed in terms of matrix factorisations.Comment: LaTeX, 19 pages, no figures; v2: title changed, minor improvements, refs added, to appear in J. Phys. A: Math. Ge

Observational Constraints on the Dependence of Radio-Quiet Quasar X-ray Emission on Black Hole Mass and Accretion Rate

In this work we use a sample of 318 radio-quiet quasars (RQQ) to investigate the dependence of the ratio of optical/UV flux to X-ray flux, alpha_ox, and the X-ray photon index, Gamma_X, on black hole mass, UV luminosity relative to Eddington, and X-ray luminosity relative to Eddington. Our sample is drawn from the SDSS, with X-ray data from ROSAT and Chandra, and optical data mostly from the SDSS; 153 of these sources have estimates of Gamma_X from Chandra. We estimate M_BH using standard estimates derived from the Hbeta, Mg II, and C IV broad emission lines. Our sample spans a broad range in black hole mass (10^6 < M_BH / M_Sun < 10^10) and redshift (z < 4.8). We find that alpha_ox increases with increasing M_BH and L_UV / L_Edd, and decreases with increasing L_X / L_Edd. In addition, we confirm the correlation seen in previous studies between Gamma_X and M_BH and both L_UV / L_Edd and L_X / L_Edd; however, we also find evidence that the dependence of Gamma_X of these quantities is not monotonic, changing sign at M_BH ~ 3 x 10^8 M_Sun. We argue that the alpha_ox correlations imply that the fraction of bolometric luminosity emitted by the accretion disk, as compared to the corona, increases with increasing accretion rate relative to Eddington. In addition, we argue that the Gamma_X trends are caused by a dependence of X-ray spectral index on accretion rate. We discuss our results within the context of accretion models with comptonizing corona, and discuss the implications of the alpha_ox correlations for quasar feedback. To date, this is the largest study of the dependence of RQQ X-ray parameters on black hole mass and related quantities, and the first to attempt to correct for the large statistical uncertainty in the broad line mass estimates.Comment: Accepted by ApJ, 23 pages, 15 figures, emulateapj styl