184 research outputs found
Characterization of Strontium Oxide Layers on Silicon for CMOS High-K Gate Stack Scaling
Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7-August 11, 201
Mass spectrometry-based characterization of the virion proteome, phosphoproteome, and associated kinase activity of human cytomegalovirus
[...] je ne sais quoi de sublime', une expérience mystique manquée dans Les Faux monnayeurs
A stacking-fault based microscopic model for platelets in diamond
We propose a new microscopic model for the planar defects in
diamond commonly called platelets. This model is based on the formation of a
metastable stacking fault, which can occur because of the ability of carbon to
stabilize in different bonding configurations. In our model the core of the
planar defect is basically a double layer of three-fold coordinated
carbon atoms embedded in the common diamond structure. The properties of
the model were determined using {\it ab initio} total energy calculations. All
significant experimental signatures attributed to the platelets, namely, the
lattice displacement along the direction, the asymmetry between the
and the directions, the infrared absorption peak
, and broad luminescence lines that indicate the introduction of
levels in the band gap, are naturally accounted for in our model. The model is
also very appealing from the point of view of kinetics, since naturally
occurring shearing processes will lead to the formation of the metastable
fault.Comment: 5 pages, 4 figures. Submitted for publication on August 2nd, 200
The prismatic Sigma 3 (10-10) twin bounday in alpha-Al2O3 investigated by density functional theory and transmission electron microscopy
The microscopic structure of a prismatic twin
boundary in \aal2o3 is characterized theoretically by ab-initio
local-density-functional theory, and experimentally by spatial-resolution
electron energy-loss spectroscopy in a scanning transmission electron
microscope (STEM), measuring energy-loss near-edge structures (ELNES) of the
oxygen -ionization edge. Theoretically, two distinct microscopic variants
for this twin interface with low interface energies are derived and analysed.
Experimentally, it is demonstrated that the spatial and energetical resolutions
of present high-performance STEM instruments are insufficient to discriminate
the subtle differences of the two proposed interface variants. It is predicted
that for the currently developed next generation of analytical electron
microscopes the prismatic twin interface will provide a promising benchmark
case to demonstrate the achievement of ELNES with spatial resolution of
individual atom columns
In vitro production of cat-restricted Toxoplasma pre-sexual stages
Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely uncharted owing to ethical concerns regarding the use of cats as model organisms. Chromatin modifiers dictate the developmental fate of the parasite during its multistage life cycle, but their targeting to stage-specific cistromes is poorly described. Here we found that the transcription factors AP2XII-1 and AP2XI-2 operate during the tachyzoite stage, a hallmark of acute toxoplasmosis, to silence genes necessary for merozoites, a developmental stage critical for subsequent sexual commitment and transmission to the next host, including humans. Their conditional and simultaneous depletion leads to a marked change in the transcriptional program, promoting a full transition from tachyzoites to merozoites. These in vitro-cultured pre-gametes have unique protein markers and undergo typical asexual endopolygenic division cycles. In tachyzoites, AP2XII-1 and AP2XI-2 bind DNA as heterodimers at merozoite promoters and recruit MORC and HDAC3 (ref. ), thereby limiting chromatin accessibility and transcription. Consequently, the commitment to merogony stems from a profound epigenetic rewiring orchestrated by AP2XII-1 and AP2XI-2. Successful production of merozoites in vitro paves the way for future studies on Toxoplasma sexual development without the need for cat infections and holds promise for the development of therapies to prevent parasite transmission
Density functional theory calculations of the carbon ELNES of small diameter armchair and zigzag nanotubes: core-hole, curvature and momentum transfer orientation effects
We perform density functional theory calculations on a series of armchair and
zigzag nanotubes of diameters less than 1nm using the all-electron
Full-Potential(-Linearised)-Augmented-Plane-Wave (FPLAPW) method. Emphasis is
laid on the effects of curvature, the electron beam orientation and the
inclusion of the core-hole on the carbon electron energy loss K-edge. The
electron energy loss near-edge spectra of all the studied tubes show strong
curvature effects compared to that of flat graphene. The curvature induced
hybridisation is shown to have a more drastic effect on the
electronic properties of zigzag tubes than on those of armchair tubes. We show
that the core-hole effect must be accounted for in order to correctly reproduce
electron energy loss measurements. We also find that, the energy loss near edge
spectra of these carbon systems are dominantly dipole selected and that they
can be expressed simply as a proportionality with the local momentum projected
density of states, thus portraying the weak energy dependence of the transition
matrix elements. Compared to graphite, the ELNES of carbon nanotubes show a
reduced anisotropy.Comment: 25 pages, 15 figures, revtex4 submitted for publication to Phys. Rev.
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