MRI of the lung (2/3). Why … when … how?

Background Among the modalities for lung imaging, proton magnetic resonance imaging (MRI) has been the latest to be introduced into clinical practice. Its value to replace X-ray and computed tomography (CT) when radiation exposure or iodinated contrast material is contra-indicated is well acknowledged: i.e. for paediatric patients and pregnant women or for scientific use. One of the reasons why MRI of the lung is still rarely used, except in a few centres, is the lack of consistent protocols customised to clinical needs. Methods This article makes non-vendor-specific protocol suggestions for general use with state-of-the-art MRI scanners, based on the available literature and a consensus discussion within a panel of experts experienced in lung MRI. Results Various sequences have been successfully tested within scientific or clinical environments. MRI of the lung with appropriate combinations of these sequences comprises morphological and functional imaging aspects in a single examination. It serves in difficult clinical problems encountered in daily routine, such as assessment of the mediastinum and chest wall, and even might challenge molecular imaging techniques in the near future. Conclusion This article helps new users to implement appropriate protocols on their own MRI platforms. Main Messages • MRI of the lung can be readily performed on state-of-the-art 1.5-T MRI scanners. • Protocol suggestions based on the available literature facilitate its use for routine • MRI offers solutions for complicated thoracic masses with atelectasis and chest wall invasion. • MRI is an option for paediatrics and science when CT is contra-indicate

Parametric exploration of the liver by magnetic resonance methods

MRI, as a completely noninvasive technique, can provide quantitative assessment of perfusion, diffusion, viscoelasticity and metabolism, yielding diverse information about liver function. Furthermore, pathological accumulations of iron and lipids can be quantified. Perfusion MRI with various contrast agents is commonly used for the detection and characterization of focal liver disease and the quantification of blood flow parameters. An extended new application is the evaluation of the therapeutic effect of antiangiogenic drugs on liver tumours. Novel, but already widespread, is a histologically validated relaxometry method using five gradient echo sequences for quantifying liver iron content elevation, a measure of inflammation, liver disease and cancer. Because of the high perfusion fraction in the liver, the apparent diffusion coefficients strongly depend on the gradient factors used in diffusion-weighted MRI. While complicating analysis, this offers the opportunity to study perfusion without contrast injection. Another novel method, MR elastography, has already been established as the only technique able to stage fibrosis or diagnose mild disease. Liver fat content is accurately determined with multivoxel MR spectroscopy (MRS) or by faster MRI methods that are, despite their widespread use, prone to systematic error. Focal liver disease characterisation will be of great benefit once multivoxel methods with fat suppression are implemented in proton MRS, in particular on high-field MR systems providing gains in signal-to-noise ratio and spectral resolution

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

Monsters and babies from the first/IRAS survey

Radio continuum emission at cm wavelengths is relatively little affected by extinction. When combined with far-infrared (FIR) surveys this provides for a convenient and unbiased method to select (radio-loud) AGN and starbursts deeply embedded in gas and dust-rich galaxies. Such radio-selected FIR samples are useful for detailed investigations of the complex relationships between (radio) galaxy and starburst activity, and to determine whether ULIRGs are powered by hidden quasars (monsters) or young stars (babies). We present the results of a large program to obtain identifications and spectra of radio-sleected, optically faint IRAS/FSC objects using the FIRST/VLA 20 cm survey (Becker, White and Helfand 1995). These objects are all radio-'quiet' in the sense that their radio power/FIR luminosities follow the well-known radio/FIR relationship for star forming galaxies. We compare these results to a previous study by our group of a sample of radio-'loud' IRAS/FSC ULIRGs selected from the Texas 365 MHz survey (Douglas et al. 1996). Many of these objects also show evidence for dominant, A-type stellar populations, as well as high ionization lines usually associated with AGN. These radio-loud ULIRGs have properties intermediate between those of starbursts and quasars, suggesting a possibile evolutionary connection. Deep Keck spectroscopic observations of three ULIRGs from these samples are presented, including high signal-to-noise spectropolarimetry. The polarimetry observations failed to show evidence of a hidden quasar in polarized (scattered) light in the two systems in which the stellar light was dominated by A-type stars. Although observations of a larger sample would be needed to allow a general conclusion, our current data suggest that a large fraction of ULIRGs may be powered by luminous starbursts, not by hidden, luminous AGN (quasars). While we used radio-selected FIR sources to search for evidence of a causal AGN/starburst connection, we conclude our presentation with a dramatic example of an AGN/starburst object from an entirely unrelated quasar survey selected at the opposite, blue end of the spectrum

HST Observations of the Host Galaxies of High Redshift Radio-Loud Quasars

Wetensch. publicatieFaculteit der Wiskunde en Natuurwetenschappe