2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry

Objectives: Specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population. Background: We sought to re-evaluate the frequency, manifestations, and severity of acute adverse reactions associated with administration of several gadolinium- based contrast agents during routine CMR on a European level. Methods: Multi-centre, multi-national, and multi-ethnical registry with consecutive enrolment of patients in 57 European centres. Results: During the current observation 37788 doses of Gadolinium based contrast agent were administered to 37788 patients. The mean dose was 24.7 ml (range 5–80 ml), which is equivalent to 0.123 mmol/kg (range 0.01 - 0.3 mmol/kg). Forty-five acute adverse reactions due to contrast administration occurred (0.12 %). Most reactions were classified as mild (43 of 45) according to the American College of Radiology definition. The most frequent complaints following contrast administration were rashes and hives (15 of 45), followed by nausea (10 of 45) and flushes (10 of 45). The event rate ranged from 0.05 % (linear non-ionic agent gadodiamide) to 0.42 % (linear ionic agent gadobenate dimeglumine). Interestingly, we also found different event rates between the three main indications for CMR ranging from 0.05 % (risk stratification in suspected CAD) to 0.22 % (viability in known CAD). Conclusions: The current data indicate that the results of the earlier safety data hold true in this much larger multi-national and multi-ethnical population. Thus, the “off-label” use of Gadolinium based contrast in cardiovascular MR should be regarded as safe concerning the frequency, manifestation and severity of acute events

Photon-Assisted Transport Through Ultrasmall Quantum Dots: Influence of Intradot Transitions

We study transport through one or two ultrasmall quantum dots with discrete energy levels to which a time-dependent field is applied (e.g., microwaves). The AC field causes photon-assisted tunneling and also transitions between discrete energy levels of the dot. We treat the problem by introducing a generalization of the rotating-wave approximation to arbitrarily many levels. We calculate the dc-current through one dot and find satisfactory agreement with recent experiments by Oosterkamp et al. . In addition, we propose a novel electron pump consisting of two serially coupled single-level quantum dots with a time-dependent interdot barrier.Comment: 16 pages, Revtex, 10 eps-figure

J1−J2J_1-J_2 Quantum Heisenberg Antiferromagnet: Improved Spin-Wave Theories Versus Exact-Diagonalization Data

We reconsider the results cocerning the extreme-quantum $S=1/2$ square-lattice Heisenberg antiferromagnet with frustrating diagonal couplings ($J_1-J_2$ model) drawn from a comparison with exact-diagonalization data. A combined approach using also some intrinsic features of the self-consistent spin-wave theory leads to the conclusion that the theory strongly overestimates the stabilizing role of quantum flutcuations in respect to the N\'{e}el phase in the extreme-quantum case $S=1/2$. On the other hand, the analysis implies that the N\'{e}el phase remains stable at least up to the limit $J_{2}/J_{1} = 0.49$ which is pretty larger than some previous estimates. In addition, it is argued that the spin-wave ansatz predicts the existence of a finite range ($J_{2}/J_{1}<0.323$ in the linear spin-wave theory) where the Marshall-Peierls sigh rule survives the frustrations.Comment: 13 pages, LaTex, 7 figures on reques

On the Coexistence of Diagonal and off-Diagonal Long-Range Order, a Monte Carlo Study

The zero temperature properties of interacting 2 dimensional lattice bosons are investigated. We present Monte Carlo data for soft-core bosons that demonstrate the existence of a phase in which crystalline long-range order and off-diagonal long-range order (superfluidity) coexist. We comment on the difference between hard and soft-core bosons and compare our data to mean-field results that predict a larger coexistence region. Furthermore, we determine the critical exponents for the various phase transitions.Comment: 7 pages and 8 figures appended in postscript, KA-TFP-93-0

One-dimensional Josephson arrays as superlattices for single Cooper pairs

We investigate uniform one-dimensional arrays of small Josephson junctions ($E_J \ll E_C$, $E_C = (2e)^2/2C$) with a realistic Coulomb interaction $U(x) = E_C \lambda \exp( - |x|/\lambda)$ (here $\lambda \gg 1$ is the screening length in units of the lattice constant of the array). At low energies this system can be described in terms of interacting Bose particles (extra single Cooper pairs) on the lattice. With increasing concentration $\nu$ of extra Cooper pairs, a crossover from the Bose gas phase to the Wigner crystal phase and then to the superlattice regime occurs. The phase diagram in the superlattice regime consists of commensurable insulating phases with $\nu = 1/l$ ($l$ is integer) separated by superconducting regions where the current is carried by excitations with {\em fractional} electric charge $q = \pm 2e/l$. The Josephson current through a ring-shaped array pierced by magnetic flux is calculated for all of the phases.Comment: 4 pages (LATEX), 2 figure

Superconductor-insulator transition driven by local dephasing

We consider a system where localized bound electron pairs form an array of "Andreev"-like scattering centers and are coupled to a fermionic subsystem of uncorrelated electrons. By means of a path-integral approach, which describes the bound electron pairs within a coherent pseudospin representation, we derive and analyze the effective action for the collective phase modes which arise from the coupling between the two subsystems once the fermionic degrees of freedom are integrated out. This effective action has features of a quantum phase model in the presence of a Berry phase term and exhibits a coupling to a field which describes at the same time the fluctuations of density of the bound pairs and those of the amplitude of the fermion pairs. Due to the competition between the local and the hopping induced non-local phase dynamics it is possible, by tuning the exchange coupling or the density of the bound pairs, to trigger a transition from a phase ordered superconducting to a phase disordered insulating state. We discuss the different mechanisms which control this occurrence and the eventual destruction of phase coherence both in the weak and strong coupling limit.Comment: 16 pages, 5 figures, submitted to PRB (05-Feb04

Effects of dephasing on shot-noise in an electronic Mach-Zehnder interferometer

We present a theoretical study of the influence of dephasing on shot noise in an electronic Mach-Zehnder interferometer. In contrast to phenomenological approaches, we employ a microscopic model where dephasing is induced by the fluctuations of a classical potential. This enables us to treat the influence of the environment's fluctuation spectrum on the shot noise. We compare against the results obtained from a simple classical model of incoherent transport, as well as those derived from the phenomenological dephasing terminal approach, arguing that the latter runs into a problem when applied to shot noise calculations for interferometer geometries. From our model, we find two different limiting regimes: If the fluctuations are slow as compared to the time-scales set by voltage and temperature, the usual partition noise expression T(1-T) is averaged over the fluctuating phase difference. For the case of ``fast'' fluctuations, it is replaced by a more complicated expression involving an average over transmission amplitudes. The full current noise also contains other contributions, and we provide a general formula, as well as explicit expressions and plots for specific examples.Comment: 18 pages, 8 figures. A brief version is contained in cond-mat/030650

Spin dynamics for bosons in an optical lattice

We study the internal dynamics of bosonic atoms in an optical lattice. Within the regime in which the atomic crystal is a Mott insulator with one atom per well, the atoms behave as localized spins which interact according to some spin Hamiltonian. The type of Hamiltonian (Heisenberg, Ising), and the sign of interactions may be tuned by changing the properties of the optical lattice, or applying external magnetic fields. When, on the other hand, the number of atoms per lattice site is unknown, we can still use the bosons to perform general quantum computation