A reaction–diffusion analysis of energetics in large muscle fibers secondarily evolved for aerobic locomotor function

The muscles that power swimming in the blue crab, Callinectes sapidus, grow hypertrophically, such that in juvenile crabs the cell diameters ar

Evaluating regulatory strategies for mitigating hydrological risk in Brazil through diversification of its electricity mix

Hydroelectricity provides approximately 65% of Brazil’s power generating capacity, making the country vulnerable to droughts, which are becoming increasingly frequent. Current energy law and policy responses to the problem rely on a sectorial approach and prioritise energy security and market regulation. Brazil has opted to increase energy security levels during periods of hydrological variability with national grid interconnection and thermal plants backup. Additionally, Brazil has created the Energy Reallocation Mechanism (MRE) to manage the generators’ financial impacts in times of insufficient water. This policy, however, was unable to avoid the high financial exposure of generators in the spot market during the severe droughts experienced in the period 2013-2017. To explore how a more diversified electricity matrix can contribute to reducing hydrological risk, this article uses Integrated Assessment Modelling (IAM) techniques to analyse future macroeconomic and energy scenarios for Brazil in a global context, aligned with the Brazilian Nationally Determined Contributions (NDC) under the 2015 Paris Agreement on Climate Change. We show that the addition of non-hydro renewables is an advantage from the integrated Water-Energy-Food nexus perspective because it reduces trade-offs amongst the water and energy sectors. Our conclusions suggest that a nexus perspective can provide useful insights on how to design energy laws and policies.Philomathia Foundation; Cambridge Humanities Research Grant

Statins, bone, and neurofibromatosis type 1

Neurofibromatosis type 1 (NF1) is a dominantly inherited multi-system disorder. Major features include pigmentary abnormalities, benign tumors of the nerve sheath (neurofibromas), malignant tumors, learning disabilities, and skeletal dysplasia. The NF1 gene functions as a tumor suppressor, but haploinsuffiency probably accounts for some aspects of the non-tumor phenotype. The protein product, neurofibromin, is a Ras GTPase-activating protein, and various Ras pathway inhibitors are being tested in preclinical models and clinical trials for effectiveness in treating NF1 complications. This month in BMC Medicine, a paper by Kolanczyk et al describes a preclinical mouse model for tibial dysplasia and provides evidence that the drug lovastatin – in use to treat cardiovascular disease – may be beneficial, opening the door to clinical trials in humans

Photosynthesis by six portuguese maize cultivars during drought stress and recovery

Photosynthesis, chlorophyll fluorescence and leaf water parameters were measured in six Portuguese maize (Zea mays L.) cultivars during and following a period of drought stress. The leaf relative water content (RWC) responded differently among cultivars but, except for cultivar PB369, recovered close to initial values after watering was restored. Photosynthetic rate and stomatal conductance decreased with drought but more slowly in cultivars PB269 and PB260 than in cultivars AD3R, PB64, PB304 and PB369. Water use efficiency (WUE) decreased during the water stress treatment although with cultivar PB260 the decrease was marked only when the RWC fell below 40%. Recovery of WUE was seen with all cultivars except PB369. The maximum quantum efficiency of photosystem II, the photochemical quenching coefficient, the electron transport rate in PSII and the estimated functional plastoquinone pool tended to decrease with drought, while the non -photochemical quenching coefficient increased. The parameters estimated from chlorophyll fluorescence did not recover in PB369, during re - watering. The results show that PB260 and PB269 were the most tolerant and PB369 was the least tolerant cultivars to water stress. The variation found amongst the cultivars tested suggests the existence of valuable genetic resources for crop improvement in relation to drought tolerance

Different molecular conformations in the crystal structures of three 5-nitroimidazolyl derivatives

Acknowledgements We thank the EPSRC National Crystallography Service (University of Southampton) for the X-ray data collections.Peer reviewedPublisher PD

On the nature and variability of the east Greenland Spill Jet : a case study in Summer 2003

Author Posting. © American Meteorological Society, 2011. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 41 (2011): 2307–2327, doi:10.1175/JPO-D-10-05004.1.Results from a high-resolution (~2 km) numerical simulation of the Irminger Basin during summer 2003 are presented. The focus is on the East Greenland Spill Jet, a recently discovered component of the circulation in the basin. The simulation compares well with observations of surface fields, the Denmark Strait overflow (DSO), and the hydrographic structure of typical sections in the basin. The model reveals new aspects of the circulation on scales of O(0.1–10) days and O(1–100) km. The model Spill Jet results from the cascade of dense waters over the East Greenland shelf. Spilling can occur in various locations southwest of the strait, and it is present throughout the simulation but exhibits large variations on periods of O(0.1–10) days. The Spill Jet sometimes cannot be distinguished in the velocity field from surface eddies or from the DSO. The vorticity structure of the jet confirms its unstable nature with peak relative and tilting vorticity terms reaching twice the planetary vorticity term. The average model Spill Jet transport is 4.9 ±1.7 Sv (1 Sv ≡ 106 m3 s−1) equatorward, about 2½ times larger than has been previously reported from a single ship transect in August 2001. Kinematic analysis of the model results suggests two different types of spilling events. In the first case (type I), a local perturbation results in dense waters descending over the shelf break into the Irminger Basin. In the second case (type II), surface cyclones associated with DSO deep domes initiate the spilling process. During summer 2003, more than half of the largest Spill Jet transport values are of type II.The research is supported by the National Science Foundation Grants OCE-0726393 and OCI-0904640 (MGM and TWNH) and OCE-0726640 (RSP).2012-06-0

Identification of a Novel Response Regulator, Crr1, That Is Required for Hydrogen Peroxide Resistance in Candida albicans

Candida albicans colonises numerous niches within humans and thus its success as a pathogen is dependent on its ability to adapt to diverse growth environments within the host. Two component signal transduction is a common mechanism by which bacteria respond to environmental stimuli and, although less common, two component-related pathways have also been characterised in fungi. Here we report the identification and characterisation of a novel two component response regulator protein in C. albicans which we have named CRR1 (Candida Response Regulator 1). Crr1 contains a receiver domain characteristic of response regulator proteins, including the conserved aspartate that receives phosphate from an upstream histidine kinase. Significantly, orthologues of CRR1 are present only in fungi belonging to the Candida CTG clade. Deletion of the C. albicans CRR1 gene, or mutation of the predicted phospho-aspartate, causes increased sensitivity of cells to the oxidising agent hydrogen peroxide. Crr1 is present in both the cytoplasm and nucleus, and this localisation is unaffected by oxidative stress or mutation of the predicted phospho-aspartate. Furthermore, unlike the Ssk1 response regulator, Crr1 is not required for the hydrogen peroxide-induced activation of the Hog1 stress-activated protein kinase pathway, or for the virulence of C. albicans in a mouse model of systemic disease. Taken together, our data suggest that Crr1, a novel response regulator restricted to the Candida CTG clade, regulates the response of C. albicans cells to hydrogen peroxide in a Hog1-independent manner that requires the function of the conserved phospho-aspartate