The North Wyke Farm Platform: Methodologies Used in the Remote Sensing of the Quantity and Quality of Drainage Water

The North Wyke Farm Platform(NWFP) for agri-environmental research in temperate grassland was established in the UK in 2010 (Orr et al. 2011). Here we describe the instrumentation and methodologies used to monitor the quantity and quality of drainage water at a total of 15 H-flumes draining 5 sub-catchments within three farmlets. Each of 15 flume laboratories is supplied with 3 kW of mains power and connected to both fibre optic and UHF (Ultra High Frequency) radio networks for data exchange. The radio data network also provides telemetry for rain gauges and soil temperature/moisture probes located away from the flumes and within the catchment blocks. Water flow is measured using bubbler flow meters and when flow is above a defined threshold level, water is pumped into bespoke 13-litre stainless steel bypass cells on a 15-minute cycle using bi-directional peristaltic pumps. A range of sensors located within the bypass cells measure the following water quality parameters: nitrate, ammonium, dissolved organic carbon, temperature, conductivity, turbidity, pH and dissolved oxygen. Total phosphorus and ortho phosphorus are measured at one flume in each farmlet. Networked auto-samplers are also provided at each flume site for the measurement of other wa-ter quality parameters as required. All data are logged and sent to a dedicated server at a 15 min resolution while a web front end allows advanced visualization capabilities and remote control of the entire system. The system is configured to allow for flexibility and future expansion to a wider range of parameters

The North Wyke Farm Platform: A New UK National Capability for Research into Sustainability of Agricultural Temperate Grassland Management

The North Wyke Farm Platform is a new UK National Capability that will enable studies that can be closely monitored and controlled under different land-use options at the farm-scale. As a Biotechnology and Biological Sciences Research Council-funded National Capability, the Farm Platform provides centralised scientific facilities including core data (field and water chemistry, water flow rates, greenhouse gas emissions from soils, livestock and agronomic data, and farm management records). Access to the Farm Platform for experimental work or to data will be available to other research users and collaborators. This shared approach will enhance the depth and breadth of information gained for the benefit of the wider community

In-spiraling Clumps in Blue Compact Dwarf Galaxies

Giant star-formation clumps in dwarf irregular galaxies can have masses exceeding a few percent of the galaxy mass enclosed inside their orbital radii. They can produce sufficient torques on dark matter halo particles, halo stars, and the surrounding disk to lose their angular momentum and spiral into the central region in 1 Gyr. Pairs of giant clumps with similarly large relative masses can interact and exchange angular momentum to the same degree. The result of this angular momentum loss is a growing central concentration of old stars, gas, and star formation that can produce a long-lived starburst in the inner region, identified with the BCD phase. This central concentration is proposed to be analogous to the bulge in a young spiral galaxy. Observations of star complexes in five local BCDs confirm the relatively large clump masses that are expected for this process. The observed clumps also seem to contain old field stars, even after background light subtraction, in which case the clumps may be long-lived. The two examples with clumps closest to the center have the largest relative clump masses and the greatest contributions from old stars. An additional indication that the dense central regions of BCDs are like bulges is the high ratio of the inner disk scale height to the scale length, which is comparable to 1 for four of the galaxies.Comment: 15 pages, 2 figures, accepted by ApJ 1/5/201

Conservative management of Paget disease of the breast with radiotherapy

BACKGROUND At 5-year follow-up, patients with Paget disease of the breast who were treated with breast-conserving surgery (BCS) and radiotherapy (RT) had excellent results. The current report provides 10- and 15-year rates of tumor control in the breast, as well as disease-free and overall survival rates following BCS and RT in a cohort of patients with Paget disease presenting without a palpable mass or mammographic density. METHODS Through a collaborative review of patients treated with BCS and RT from seven institutions, 38 cases of Paget disease of the breast presenting without a palpable mass or mammographic density were identified. All patients had pathologic confirmation of typical Paget cells at time of diagnosis. Thirty-six of 38 patients had a minimum follow-up greater than 12 months and constitute the study cohort. Ninety-four percent of patients underwent complete or partial excision of the nipple-areola complex and all patients received a median external beam irradiation dose of 50 Gy (range, 45–54 Gy) to the whole breast. Ninety-seven percent of patients also received a boost to the remaining nipple or tumor bed, a median total dose of 61.5 Gy (range, 50.4–70 Gy). RESULTS With median follow-up of 113 months (range, 18–257 months), 4 of 36 patients (11%) developed a first recurrence of disease in the treated breast only. Two of the four recurrences in the breast were ductal carcinoma in situ (DCIS) only and two were invasive with DCIS. Two additional patients had a recurrence in the breast as a component of first failure. Actuarial local control rates for the breast as the only site of first recurrence were 91% at 5 years (95% confidence interval [CI], 80–100%) and 87% (95% CI, 75–99%) at both 10 and 15 years. Actuarial local control rates for breast recurrence, as a component of first failure, were 91% (95% CI, 80–100%), 83% (95% CI, 69–97%), and 76% (95% CI, 58–94%) at 5, 10, and 15 years, respectively. No clinical factors were identified as significant predictors for breast recurrence. Five-, 10- and 15-year actuarial rates for survival without disease of 97% (95% CI, 90–100%) and 5-, 10-, and 15-year actuarial rates of overall survival of 93% (95% CI, 84–100%) at 5 years and 90% (95% CI, 78–100%) at 10 and 15 years were reported. CONCLUSIONS These data confirm excellent rates of local control, disease-free survial, and overall survival at 10 and 15 years following BCS and RT for Paget disease of the breast. This study continues to support the recommendation of local excision and definitive breast irradiation as an alternative to mastectomy in the treatment of patients with Paget disease presenting without a palpable mass or mammographic density. Cancer 2003;97:2142–9. © 2003 American Cancer Society. DOI 10.1002/cncr.11337Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34369/1/11337_ftp.pd

A longitudinal analysis of urological chronic pelvic pain syndrome flares in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151272/1/bju14783.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151272/2/bju14783_am.pd

Embracing ligands. Synthesis, characterisation and the correlation between 59Co NMR and ligand field parameters of Co(III) complexes with a new class of nitrogen-thioether multidentate ligand

The syntheses of the hexadentate ligands 2,2,10,10-tetra(methyleneamine)-4,8-dithiaundecane (PrN(4)S(2)amp), 2,2,11,11-tetra(methyleneamine)-4,9-dithiadodecane (BuN(4)S(2)amp), and 1,2-bis(4,4-methyleneamine)-2-thiapentyl)benzene (XyN(4)S(2)amp) are reported and the complexes [Co(RN(4)S(2)amp)](3+) (R = Pr, Bu, Xy) characterised by single crystal X-ray study. The low-temperature (11 K) absorption spectra have been measured in Nafion films. From the observed positions of both spin-allowed (1)A(1g) --> T-1(1g) and (1)A(1g) --> T-1(2g) and spin forbidden (1)A(1g) --> T-3(1g) and (1)A(1g) --> T-3(2g) bands, octahedral ligand-field parameters (10D(q), B and C) have been determined. DFT calculations suggest that significant interaction between the d-d and CT excitations occurs for the complexes. The calculations offer an explanation for the observed deviations from linearity of the relationship between Co-59 magnetogyric ratio and beta(DeltaE)(-1) (beta = the nephelauxetic ratio; DeltaE the energy of the (1)A(1g) --> T-1(1g) transition) for a series of amine and mixed amine/thioether donor complexes

A standardized comparison of commercially available prion decontamination reagents using the Standard Steel-Binding Assay

Prions are comprised principally of aggregates of a misfolded host protein and cause fatal transmissible neurodegenerative disorders of mammals, such as variant Creutzfeldt–Jakob disease in humans and bovine spongiform encephalopathy in cattle. Prions pose significant public health concerns through contamination of blood products and surgical instruments, and can resist conventional hospital sterilization methods. Prion infectivity binds avidly to surgical steel and can efficiently transfer infectivity to a suitable host, and much research has been performed to achieve effective prion decontamination of metal surfaces. Here, we exploit the highly sensitive Standard Steel-Binding Assay (SSBA) to perform a direct comparison of a variety of commercially available decontamination reagents marketed for the removal of prions, alongside conventional sterilization methods. We demonstrate that the efficacy of marketed prion decontamination reagents is highly variable and that the SSBA is able to rapidly evaluate current and future decontamination reagents