Can local vibration alter the contribution of persistent inward currents to human motoneuron firing?

Abstract: The response of spinal motoneurons to synaptic input greatly depends on the activation of persistent inward currents (PICs), which in turn are enhanced by the neuromodulators serotonin and noradrenaline. Local vibration (LV) induces excitatory Ia input onto motoneurons and may alter neuromodulatory inputs. Therefore, we investigated whether LV influences the contribution of PICs to motoneuron firing. This was assessed in voluntary contractions with concurrent, ongoing LV, as well as after a bout of prolonged LV. High-density surface electromyograms (HD-EMG) of the tibialis anterior were recorded with a 64-electrode matrix. Twenty males performed isometric, triangular, dorsiflexion contractions to 20% and 50% of maximal torque at baseline, during LV of the tibialis anterior muscle, and after 30-min of LV. HD-EMG signals were decomposed, and motor units tracked across time points to estimate PICs through a paired motor unit analysis, which quantifies motor unit recruitment–derecruitment hysteresis (ΔF). During ongoing LV, ΔF was lower for both 20% and 50% ramps. Although significant changes in ΔF were not observed after prolonged LV, a differential effect across the motoneuron pool was observed. This study demonstrates that PICs can be non-pharmacologically modulated by LV. Given that LV leads to reflexive motor unit activation, it is postulated that lower PIC contribution to motoneuron firing during ongoing LV results from decreased neuromodulatory inputs associated with lower descending corticospinal drive. A differential effect in motoneurons of different recruitment thresholds after prolonged LV is provocative, challenging the interpretation of previous observations and motivating future investigations. (Figure presented.). Key points: Neuromodulatory inputs from the brainstem influence motoneuron intrinsic excitability through activation of persistent inward currents (PICs). PICs make motoneurons more responsive to excitatory input. We demonstrate that vibration applied on the muscle modulates the contribution of PICs to motoneuron firing, as observed through analysis of the firing of single motor units. The effects of PICs on motoneuron firing were lower when vibration was concurrently applied during voluntary ramp contractions, likely due to lower levels of neuromodulation. Additionally, prolonged exposure to vibration led to differential effects of lower- vs. higher-threshold motor units on PICs, with lower-threshold motor units tending to present an increased and higher-threshold motor units a decreased contribution of PICs to motoneuron firing. These results demonstrate that muscle vibration has the potential to influence the effects of neuromodulation on motoneuron firing. The potential of using vibration as a non-pharmacological neuromodulatory intervention should be further investigated

Time Delay Predictions in a Modified Gravity Theory

The time delay effect for planets and spacecraft is obtained from a fully relativistic modified gravity theory including a fifth force skew symmetric field by fitting to the Pioneer 10/11 anomalous acceleration data. A possible detection of the predicted time delay corrections to general relativity for the outer planets and future spacecraft missions is considered. The time delay correction to GR predicted by the modified gravity is consistent with the observational limit of the Doppler tracking measurement reported by the Cassini spacecraft on its way to Saturn, and the correction increases to a value that could be measured for a spacecraft approaching Neptune and Pluto.Comment: 5 pages, LaTex file, no figures. Corrections to Table

Measuring the impact of health policies using Internet search patterns: the case of abortion

<p>Abstract</p> <p>Background</p> <p>Internet search patterns have emerged as a novel data source for monitoring infectious disease trends. We propose that these data can also be used more broadly to study the impact of health policies across different regions in a more efficient and timely manner.</p> <p>Methods</p> <p>As a test use case, we studied the relationships between abortion-related search volume, local abortion rates, and local abortion policies available for study.</p> <p>Results</p> <p>Our initial integrative analysis found that, both in the US and internationally, the volume of Internet searches for abortion is inversely proportional to local abortion rates and directly proportional to local restrictions on abortion.</p> <p>Conclusion</p> <p>These findings are consistent with published evidence that local restrictions on abortion lead individuals to seek abortion services outside of their area. Further validation of these methods has the potential to produce a timely, complementary data source for studying the effects of health policies.</p

Participatory Epidemiology: Use of Mobile Phones for Community-Based Health Reporting

Clark Freifeld and colleagues discuss mobile applications, including their own smartphone application, that show promise for health monitoring and information sharing

Blogging in the physics classroom: A research-based approach to shaping students' attitudes towards physics

Even though there has been a tremendous amount of research done in how to help students learn physics, students are still coming away missing a crucial piece of the puzzle: why bother with physics? Students learn fundamental laws and how to calculate, but come out of a general physics course without a deep understanding of how physics has transformed the world around them. In other words, they get the "how" but not the "why". Studies have shown that students leave introductory physics courses almost universally with decreased expectations and with a more negative attitude. This paper will detail an experiment to address this problem: a course weblog or "blog" which discusses real-world applications of physics and engages students in discussion and thinking outside of class. Specifically, students' attitudes towards the value of physics and its applicability to the real-world were probed using a 26-question Likert scale survey over the course of four semesters in an introductory physics course at a comprehensive Jesuit university. We found that students who did not participate in the blog study generally exhibited a deterioration in attitude towards physics as seen previously. However, students who read, commented, and were involved with the blog maintained their initially positive attitudes towards physics. Student response to the blog was overwhelmingly positive, with students claiming that the blog made the things we studied in the classroom come alive for them and seem much more relevant.Comment: 20 pages, 6 figure

Gravitational solution to the Pioneer 10/11 anomaly

A fully relativistic modified gravitational theory including a fifth force skew symmetric field is fitted to the Pioneer 10/11 anomalous acceleration. The theory allows for a variation with distance scales of the gravitational constant G, the fifth force skew symmetric field coupling strength omega and the mass of the skew symmetric field mu=1/lambda. A fit to the available anomalous acceleration data for the Pioneer 10/11 spacecraft is obtained for a phenomenological representation of the "running" constants and values of the associated parameters are shown to exist that are consistent with fifth force experimental bounds. The fit to the acceleration data is consistent with all current satellite, laser ranging and observations for the inner planets.Comment: 14 pages, 3 figures, 3 tables. typo's were corrected at Equations (4) and (12) and a third table including our predictions for the anomalous perihelion advance of the planets was adde

Supersymmetry in quantum mechanics: An extended view

The concept of supersymmetry in a quantum mechanical system is extended, permitting the recognition of many more supersymmetric systems, including very familiar ones such as the free particle. Its spectrum is shown to be supersymmetric, with space-time symmetries used for the explicit construction. No fermionic or Grassmann variables need to be invoked. Our construction extends supersymmetry to continuous spectra. Most notably, while the free particle in one dimension has generally been regarded as having a doubly degenerate continuum throughout, the construction clarifies taht there is a single zero energy state at the base of the spectrum.Comment: 4 pages, 4 figure

Ecotones as indicators: boundary properties in wetland-woodland transition zones

Ecotones, representing the transition zones between species or communities, have been suggested as focal points for detecting early shifts in vegetation composition due to anthropogenic impact. Here we examined if changes in ecotone location or properties can be used as reliable indicators of hydrological change in temperate wetland communities. We examined 38 woodland-wetland-woodland transitions, distributed across four sites with different anthropogenic disturbance histories and hydrological traits. We tested whether: 1) the ecotones are associated with environmental gradients, and 2) the location or properties of these ecotones change with disturbance history. Well-defined ecotones were associated with steep gradients in soil depth and soil moisture. Most ecotones showed a change in vegetation from hydrophytic to dryland species. There was also some evidence that in highly disturbed sites the link between ecotones and environmental gradients was less apparent. By sampling across boundaries we can better understand the factors controlling the distribution of species. This allows us to make better predictions about the impacts of anthropogenic change in wetland communities. By investigating the transitions between different vegetation communities we were able to highlight key indicators that could be used to monitor these ecologically sensitive and diverse wetland communities

A seven square degrees survey for galaxy-scale gravitational lenses with the HST imaging archive

We present the results of a visual search for galaxy-scale gravitational lenses in nearly 7 square degrees of Hubble Space Telescope (HST) images. The dataset comprises the whole imaging data ever taken with the Advanced Camera for Surveys (ACS) in the filter F814W (I-band) up to August 31st, 2011, i.e. 6.03 square degrees excluding the field of the Cosmic Evolution Survey (COSMOS) which has been the subject of a separate visual search. In addition, we have searched for lenses in the whole Wide Field Camera 3 (WFC3) near-IR imaging dataset in all filters (1.01 square degrees) up to the same date. Our primary goal is to provide a sample of lenses with a broad range of different morphologies and lens-source brightness contrast in order estimate a lower limit to the number of galaxy-scale strong lenses in the future Euclid survey in its VIS band. Our criteria to select lenses are purely morphological as we do not use any colour or redshift information.The final candidate selection is very conservative hence leading to a nearly pure but incomplete sample. We find 49 new lens candidates: 40 in the ACS images and 9 in the WFC3 images. Out of these, 16 candidates are secure lenses owing to their striking morphology, 21 more are very good candidates, and 12 more have morphologies compatible with gravitational lensing but also compatible with other astrophysical objects. It is therefore insensitive to cosmic variance and allows to estimate the number of galaxy-scale strong lenses on the sky for a putative survey depth, which is the main result of the present work. Because of the incompleteness of the sample, the estimated lensing rates should be taken as lower limits. Using these, we anticipate that a 15 000 square degrees space survey such as Euclid will find at least 60 000 galaxy-scale strong lenses down to a limiting AB magnitude of I = 24.5 (10-sigma) or I = 25.8 (3-sigma).Comment: 13 pages, 12 figures, Accepted for publication in MNRA