A Template for Implementing Fast Lock-free Trees Using HTM

Algorithms that use hardware transactional memory (HTM) must provide a software-only fallback path to guarantee progress. The design of the fallback path can have a profound impact on performance. If the fallback path is allowed to run concurrently with hardware transactions, then hardware transactions must be instrumented, adding significant overhead. Otherwise, hardware transactions must wait for any processes on the fallback path, causing concurrency bottlenecks, or move to the fallback path. We introduce an approach that combines the best of both worlds. The key idea is to use three execution paths: an HTM fast path, an HTM middle path, and a software fallback path, such that the middle path can run concurrently with each of the other two. The fast path and fallback path do not run concurrently, so the fast path incurs no instrumentation overhead. Furthermore, fast path transactions can move to the middle path instead of waiting or moving to the software path. We demonstrate our approach by producing an accelerated version of the tree update template of Brown et al., which can be used to implement fast lock-free data structures based on down-trees. We used the accelerated template to implement two lock-free trees: a binary search tree (BST), and an (a,b)-tree (a generalization of a B-tree). Experiments show that, with 72 concurrent processes, our accelerated (a,b)-tree performs between 4.0x and 4.2x as many operations per second as an implementation obtained using the original tree update template

Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia

Growth arrest and DNA damage protein 34 (GADD34) is a multifunctional protein upregulated in response to cellular stress and is believed to mediate DNA repair and restore protein synthesis. In the present study we have examined GADD34 immunoreactivity in human myocardial tissue at defined survival times following cardiac arrest and determined alterations in expression following ischaemia. In the normal human heart, GADD34 immunoreactivity was generally intense and present within most cells. GADD34 immunoreactivity was downregulated in tissue displaying ischaemic damage and remained intense in adjacent non-infarcted tissue. Unlike brain, GADD34 was not found to be upregulated in the peri-infarct zone. Cells displaying apoptotic changes were located in regions displaying reduced GADD34 immunoreactivity. In the brain, it is thought that GADD34 supports re-initiation of protein synthesis following ischaemia. Similarly, GADD34 may perform important functions in cardiac tissue in response to ischaemia

The Adoption of ERP Applications in China

The adoption of enterprise resource planning (ERP) applications started in the early 1990s in the US and Europe. Although many researchers have studied the critical success factors (CSFs) or developed implementation framework to guide the deployment of the complex IT projects, there have been many failed implementations. The implementation of ERP systems in China began in the late 1990s but has resulted in a disappointing success rate of about 10 percent. This paper will investigate which issues facilitate or hinder the adoption of ERP applications in China in the light of previous research reported on Western firms. The research methodology is secondary data collection and case narratives. Twenty small case studies about the implementation of ERP systems in Chinese organisations will be discussed. Since the data has been collected and presented by other practitioners for certain purposes, the limitations of this research are also considered

Spatial imaging of Zn and other elements in Huanglongbing-affected grapefruit by synchrotron-based micro X-ray fluorescence investigation

Huanglongbing (HLB) is a highly destructive, fast-spreading disease of citrus, causing substantial economic losses to the citrus industry worldwide. Nutrient levels and their cellular distribution patterns in stems and leaves of grapefruit were analysed after graft-inoculation with lemon scions containing 'Candidatus Liberibacter asiaticus' (Las), the heat-tolerant Asian type of the HLB bacterium. After 12 months, affected plants showed typical HLB symptoms and significantly reduced Zn concentrations in leaves. Micro-XRF imaging of Zn and other nutrients showed that preferential localization of Zn to phloem tissues was observed in the stems and leaves collected from healthy grapefruit plants, but was absent from HLB-affected samples. Quantitative analysis by using standard references revealed that Zn concentration in the phloem of veins in healthy leaves was more than 10 times higher than that in HLB-affected leaves. No significant variation was observed in the distribution patterns of other elements such as Ca in stems and leaves of grapefruit plants with or without graft-inoculation of infected lemon scions. These results suggest that reduced phloem transport of Zn is an important factor contributing to HLB-induced Zn deficiency in grapefruit. Our report provides the first in situ, cellular level visualization of elemental variations within the tissues of HLB-affected citrus. © 2014 © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology

The effect of 14 weeks of vitamin D3 supplementation on antimicrobial peptides and proteins in athletes

Heavy training is associated with increased respiratory infection risk and antimicrobial proteins are important in defence against oral and respiratory tract infections. We examined the effect of 14 weeks of vitamin D3 supplementation (5000 IU/day) on the resting plasma cathelicidin concentration and the salivary secretion rates of secretory immunoglobulin A (SIgA), cathelicidin, lactoferrin and lysozyme in athletes during a winter training period. Blood and saliva were obtained at the start of the study from 39 healthy men who were randomly allocated to vitamin D3 supplement or placebo. Blood samples were also collected at the end of the study; saliva samples were collected after 7 and 14 weeks. Plasma total 25(OH)D concentration increased by 130% in the vitamin D3 group and decreased by 43% in the placebo group (both P=0.001). The percentage change of plasma cathelicidin concentration in the vitamin D3 group was higher than in the placebo group (P=0.025). Only in the vitamin D3 group, the saliva SIgA and cathelicidin secretion rates increased over time (both P=0.03). A daily 5000 IU vitamin D3 supplement has a beneficial effect in up-regulating the expression of SIgA and cathelicidin in athletes during a winter training period which could improve resistance to respiratory infections

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial

Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity. A candidate gene study was conducted to assess potential association of genetic variants with GI toxicity in 808 patients who received carboplatin/taxane in the Scottish Randomized Trial in Ovarian Cancer 1 (SCOTROC1). Patients were randomized into discovery and validation cohorts consisting of 404 patients each. Clinical covariates and genetic variants associated with grade III/IV GI toxicity in discovery cohort were evaluated in replication cohort. Chemotherapy-induced GI toxicity was significantly associated with seven single-nucleotide polymorphisms in the ATP7B, GSR, VEGFA and SCN10A genes. Patients with risk genotypes were at 1.53 to 18.01 higher odds to develop carboplatin/taxane-induced GI toxicity (P<0.01). Variants in the VEGF gene were marginally associated with survival time. Our data provide potential targets for modulation/inhibition of GI toxicity in ovarian cancer patients

Relative importance of deterministic and stochastic processes for beta diversity of bird assemblages in Yunnan, China

Evaluating the relative importance of deterministic and stochastic processes underlying taxonomic and functional beta diversity is crucial in community ecology, because it can reveal the dominant processes of community assembly. However, studies of bird communities remain rare and of limited spatial extents. In this study, we described the taxonomic and functional beta diversity patterns of 32 passerine bird assemblages of Yunnan Province, China. We constructed null models based on observed species beta diversity and used multiple regressions on distance matrices to evaluate the relative contributions of deterministic and stochastic processes to passerine bird assemblage dissimilarity. Our results showed significant geographic distance decay in taxonomic and functional similarity, with passerine bird assemblages located in the northwest and southwest of the province having higher functional beta diversity values than expected. Environmental distance and geographic distance explained a similar amount taxonomic beta diversity, but environmental distance explained much more functional beta diversity. Our results suggest that both deterministic and stochastic processes drive taxonomic beta diversity, but that deterministic processes, particularly environmental filtering, play a dominant role in driving functional beta diversity of passerine bird assemblages at sub-national scale