Sound suppression mixer

A gas turbine engine flow mixer includes at least one chute having first and second spaced apart sidewalls joined together at a leading edge, with the sidewalls having first and second trailing edges defining therebetween a chute outlet. The first trailing edge is spaced longitudinally downstream from the second trailing edge for defining a septum in the first sidewall extending downstream from the second trailing edge. The septum includes a plurality of noise attenuating apertures

William H. Brown, Jr. to Mr. Meredith (7 October 1962)

https://egrove.olemiss.edu/mercorr_pro/2044/thumbnail.jp

Voiding cinema: subjectivity beside itself, or unbecoming cinema in Enter the void

This essay examines Gaspar Noë's film, Enter the Void (2009), in light of the work of both Gilles Deleuze and Alain Badiou. Arguing that the film shows to viewers the 'void' that separates subjects from objects, the essay also considers Noë's film in the light of drug literature and the altered states induced by cinema and describe by Anna Powell. Finally, the essay proposes that Enter the Void is a work of 'unbecoming' cinema, which in turn points to expansion of cinematic form through the use of digital technologies

Through a (First) Contact Lens Darkly:Arrival, Unreal Time and Chthulucinema

Science fiction is often held up as a particularly philosophical genre. For, beyond actualising mind-experiment-like fantasies, science fiction films also commonly toy with speculative ideas, or else engineer encounters with the strange and unknown. Denis Villeneuve’s Arrival (2016) is a contemporary science fiction film that does exactly this, by introducing Lovecraft-esque tentacular aliens whose arrival on Earth heralds in a novel, but ultimately paralysing, inhuman perspective on the nature of time and reality. This article shows how this cerebral film invites viewers to confront a counterintuitive model of time that at once recalls and reposes what Gilles Deleuze called a "third-synthesis" of time, and that which J. M. Ellis McTaggart named the a-temporal "C series" of "unreal" time. We finally suggest that Arrival’s a-temporal conception of the future as having already happened can function as a key to understanding the fate of humanity as a whole as we pass from the anthropocene, in which humans have dominated the planet, to the "chthulucene," in which humans no longer exist on the planet at all

Low-Dose Continuous 5-Fluorouracil Combined with Leucovorin, nab-Paclitaxel, Oxaliplatin, and Bevacizumab for Patients with Advanced Pancreatic Cancer: A Retrospective Analysis.

BackgroundContinuous-infusion 5-fluorouracil (5FU) and calcium leucovorin plus nab-paclitaxel and oxaliplatin have been shown to be active in patients with pancreatic cancer. As a protracted low-dose infusion, 5FU is antiangiogenic, and has synergy with bevacizumab. As shown in the treatment of breast cancer, bevacizumab and nab-paclitaxel are also synergetic.ObjectiveIn this paper we retrospectively analyze the survival of 65 patients with advanced pancreatic cancer who were treated with low-dose continuous (metronomic) chemotherapy given in conjunction with conventional anti-VEGF therapy.Patients and methodsSince July of 2008, we have treated 65 patients with 5FU (180 mg/m2/day × 14 days) via an ambulatory pump. Calcium leucovorin (20 mg/m2 IV), nab-paclitaxel (60 mg/m2) IV as a 30-min infusion, and oxaliplatin (50 mg/m2) IV as a 60-min infusion were given on days 1, 8, and 15. Bevacizumab (5 mg/kg) IV over 30 min was administered on days 1 and 15. Cycles were repeated every 28-35 days. There were 42 women and 23 men, and the median age was 59 years. Forty-six patients had stage IV disease.ResultsThe median survival was 19 months, with 82% of patients surviving 12 months or longer. The overall response rate was 49%. There were 28 patients who had received prior treatment, 15 of whom responded to therapy. Fifty-two patients had elevated CA 19-9 prior to treatment. Of these, 21 patients had 90% or greater reduction in CA 19-9 levels. This cohort had an objective response rate of 71% and a median survival of 27 months. Thirty patients stopped treatment due to disease progression, and an additional 22 stopped because of toxicity. One patient died while on therapy.ConclusionsThis non-gemcitabine-based regimen resulted in higher response rates and better survival than what is commonly observed with therapy given at conventional dosing schedules. Low-dose continuous (metronomic therapy) cytotoxic chemotherapy combined with antiangiogenic therapy is safe and effective

Mid to Late Holocene Population Trends, Culture Change and Marine Resource Intensification in Western Alaska

The goal of this project is to understand the influence of population size on human adaptation processes and culture change during the Mid to Late Holocene in Western Alaska. We use a database of 1180 radiocarbon dates ranging from 6000 to 1000 14C years BP and drawn from 805 archaeological components in Alaska to construct a proxy record for relative change in regional and Alaskan metapopulation sizes over time. Our analysis indicates that a major population crash coincided with the disappearance of the Arctic Small Tool tradition (ASTt) and the subsequent emergence of the Norton tradition. The ASTt population began to decline around 3600 cal BP, and by 3500 cal BP it had disappeared almost completely from northern tundra habitats, though it persisted in coastal areas in Northwest and Southwest Alaska for another 500 years. The reduction in human population across Alaska after 3600 cal BP appears linked to a reduced carrying capacity that was perhaps driven by a caribou population crash. Such a shock would have increased population pressure and fostered increased reliance on marine resources, precipitating cultural changes associated with an increasingly complex maritime economy. The sharp decline in ASTt population size reduced the number of cultural role models for this population, resulting in the loss of some of the tradition’s characteristic cultural traits, while the influence of neighboring populations in southern Alaska and across the Bering Strait apparently increased, counteracting this attrition of cultural traits. Holistic explanations of the ASTt-Norton transition must take into account population size, ecological adaptation, and cultural transmission processes, as is true for cultural change more generally.L’objectif de ce projet est de comprendre l’influence de la taille de la population sur les processus d’adaptation et le changement culturel des humains de l’Holocène moyen à l’Holocène supérieur dans l’ouest de l’Alaska. Nous nous appuyons sur une base de données contenant 1 180 datations par radiocarbone allant de 6000 à 1000 années radiocarbones BP et nous avons puisé parmi 805 composantes archéologiques en Alaska pour établir un relevé indirect des changements relatifs dans les métapopulations des régions et de l’Alaska au fil du temps. Notre analyse indique qu’un effondrement majeur de la population coïncide avec la disparition de la tradition microlithique de l’Arctique et avec l’émergence subséquente de la tradition nortonienne. La population de la tradition microlithique de l’Arctique a commencé à s’éteindre vers les années 3600 cal BP, et vers 3500 ans cal BP, elle avait presque complètement disparu des habitats de la toundra arctique, bien qu’elle ait survécu pendant encore 500 ans dans les zones côtières nord-ouest et sud-ouest de l’Alaska. Après 3600 cal BP, la diminution de la population humaine en Alaska semble avoir un lien avec la capacité de charge réduite probablement engendrée par un effondrement de la population de caribous. Un tel choc aurait contribué à augmenter la pression démographique et à favoriser la dépendance aux ressources marines, précipitant ainsi les changements culturels liés à une économie maritime de plus en plus complexe. La forte baisse de la taille de la population partageant la tradition microlithique de l’Arctique a réduit le nombre de modèles culturels de cette population, résultant ainsi en la perte de certains des traits culturels caractéristiques à cette tradition. Cependant, l’augmentation apparente de l’influence des populations avoisinantes du sud de l’Alaska et au-delà du détroit de Béring a compensé l’attrition des traits culturels. Les explications holistiques de la transition de la tradition microlithique de l’Arctique à la tradition nortonienne doivent tenir compte de la taille de la population, de l’adaptation écologique et des processus de la transmission culturelle, comme c’est le cas pour tout changement culturel en général

Wright & Miller: Federal Practice and Procedure, Civil Procedure

A Review of Federal Practice and Procedure, Civil Procedure Vol. 4 & 5 by Charles Alan Wright and Arthur R. Mille