Exposure-Lag-Response in Longitudinal Studies: Application of Distributed-Lag Nonlinear Models in an Occupational Cohort.

Prolonged exposures can have complex relationships with health outcomes, as timing, duration, and intensity of exposure are all potentially relevant. Summary measures such as cumulative exposure or average intensity of exposure may not fully capture these relationships. We applied penalized and unpenalized distributed-lag nonlinear models (DLNMs) with flexible exposure-response and lag-response functions in order to examine the association between crystalline silica exposure and mortality from lung cancer and nonmalignant respiratory disease in a cohort study of 2,342 California diatomaceous earth workers followed during 1942-2011. We also assessed associations using simple measures of cumulative exposure assuming linear exposure-response and constant lag-response. Measures of association from DLNMs were generally higher than those from simpler models. Rate ratios from penalized DLNMs corresponding to average daily exposures of 0.4 mg/m3 during lag years 31-50 prior to the age of observed cases were 1.47 (95% confidence interval (CI): 0.92, 2.35) for lung cancer mortality and 1.80 (95% CI: 1.14, 2.85) for nonmalignant respiratory disease mortality. Rate ratios from the simpler models for the same exposure scenario were 1.15 (95% CI: 0.89, 1.48) and 1.23 (95% CI: 1.03, 1.46), respectively. Longitudinal cohort studies of prolonged exposures and chronic health outcomes should explore methods allowing for flexibility and nonlinearities in the exposure-lag-response

Observable implications of geometrical and dynamical aspects of freeze-out in heavy ion collisions

Using an analytical parameterization of hadronic freeze-out in relativistic heavy ion collisions, we present a detailed study of the connections between features of the freeze-out configuration and physical observables. We focus especially on anisotropic freeze-out configurations (expected in general for collisions at finite impact parameter), azimuthally-sensitive HBT interferometry, and final-state interactions between non-identical particles. Model calculations are compared with data taken in the first year of running at RHIC; while not perfect, good agreement is found, raising the hope that a consistent understanding of the full freeze-out scenario at RHIC is possible, an important first step towards understanding the physics of the system prior to freeze-out.Comment: 36 pages, 56 figures, 2 tables; version accepted for publication in PRC: some figures, references and discussion added; now also discusses classical versus quantum statistic

Foundations and Applications of Theory in the First Impressions Program

The First Impressions program was designed to help communities learn about their strengths and shortcomings through the fresh eyes of first-time visitors. This Extension-led community assessment program has been implemented in over 500 communities since the 1990s, yet scant literature exists regarding the program\u27s theoretical foundations or best practices for implementation or evaluation. To address increasing interest in the program among Extension professionals nationwide, we aim to encourage new scholarship regarding the program\u27s use and impacts by providing an overview of how the program works; a discussion of theoretical foundations of the program from geography, urban planning, and psychology literature; and suggestions for improving program efficacy

Buckle up safely: a cluster randomised trial to evaluate the effectiveness of a pre-school based program to increase appropriate use of child restraints

BACKGROUND: Road traffic crashes for car occupants are a leading cause of death and serious injury in children from high and middle income countries globally. Correct use of appropriate child restraints can significantly reduce death and serious injury but there is a need for well powered trials to examine effectiveness of programs to increase optimal child restraint practices. The aim of this trial is to examine the effectiveness of a comprehensive intervention to increase the use of appropriate child restraints, and decrease incorrect use of child restraints in pre-school aged children traveling in cars. METHODS AND DESIGN: A cluster randomised controlled trial will be conducted, involving 28 pre-school or childcare centres in low income areas of Sydney, Australia, over one calendar year. The intervention is an educational program involving an in-service for centre staff, distribution of educational materials to parents, a parent workshop demonstrating restraint use, subsidised restraints for parents in need, and vouchers for a free restraint checking service. Blinded assessors will observe restraint use at all centres at the end of the calendar year. Data will be analysed on an intention-to-treat basis; the primary analysis will compare the proportion of each of the two outcome measures (use of appropriate restraints, and incorrect use of restraints) at each centre between intervention and control groups. Detailed process evaluation will be conducted, including examination of implementation and utilisation of various elements of the program by both centres and families. DISCUSSION: This assessor blinded cluster randomised trial is powered to provide credible evidence about the efficacy of an education and distribution program in a pre-school setting to increase appropriate use, and decrease incorrect use of child restraints. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12609000612213

Asymmetric cyclopropanation of conjugated cyanosulfones using a novel cupreine organocatalyst: rapid access to d3-amino acids

An organocatalytic asymmetric synthesis of a novel, highly functionalised cyclopropane system furnished with versatile substituents and containing a quaternary centre is described. The process utilises a new bifunctional catalyst based on the cinchona alkaloid framework and the products made using this catalyst were obtained as single diastereoisomers, with very high enantioselectivities (up to 96% ee). We have also demonstrated that these resulting cyclopropanes are very useful synthetic intermediates to interesting products, such as the difficult to access d3-amino acids

Supporting weight management services during the COVID-19 pandemic: Phase I insights

Societal changes required to manage the coronavirus (COVID-19) pandemic may have inadvertently promoted weight gain, due to the adverse impact on socio-economics, psychological health, and the resulting metabolic impact of elevated stress, emotional eating and physical inactivity. Evidence on the impact of COVID-19 has rapidly accumulated, to demonstrate that people living with obesity are at higher risk of severe illness from COVID-19 infection. It is therefore important to understand what is happening in terms of weight management practice to develop local and national thinking. This project will explore the impact of the COVID-19 upon the provision of tier 2 and 3 weight management services (WMS) in England during the lockdown period (phase I; March-June 2020); and determine what needs to happen in the future (phase II; September-November 2020). This report documents findings from phase I

NSF SSTEM MIRRORS Data 2018-2021

With five years of funding from the National Science Foundation\u27s Scholarships in Science, Technology, Engineering and Mathematics (S-STEM) program, John Carroll University (JCU) will provide scholarships to 32 students with demonstrated financial need and academic promise. The scholarships will be awarded to first-year and transfer students who are pursuing bachelor\u27s degrees in STEM in Biology, Chemistry, Mathematics, Computer Science and Physics. The Scholars in the program will receive academic support that includes a STEM-specific orientation, a summer bridge program, cohort advising, and curricula introducing scientific thinking and research.The project goals are to improve one-year retention and four-year graduation rates, and to train and graduate scholars who will meet local, regional, and national demands for a STEM-educated workforce. This project will provide evidence-based academic and student support services designed to support the transition and success of JCU transfer student cohorts. These services include a STEM living-learning community (LLC), peer-led team learning, career development, summer research fellowships, and travel to scientific meetings. This project will contribute to education research by investigating the role of reflection (i.e., conscientious evaluation of new knowledge or experiences) in the development of student-scientists, and the influence of STEM LLCs on student persistence and sense of well-being. The ongoing process of reflection is critical for academic success, social well-being, and vocational self-efficacy. However, the importance of reflection as a tool for success in STEM disciplines is unknown. This project will assess reflection as a tool to increase retention and performance in STEM experimentally, by monitoring performance indicators for S-STEM Scholars compared to the pool of S-STEM-eligible students who were not selected for a scholarship and therefore did not participate in the program\u27s reflection activities. Finally, this project will help provide S-STEM students the opportunity to be successful in high-demand STEM disciplines

The prevalence of mental health problems among users of NHS stop smoking services: effects of implementing a routine screening procedure

<p>Abstract</p> <p>Background</p> <p>Tobacco dependence among people with mental health problems is an issue that deserves attention both from a clinical and from a public health perspective. Research suggests that Stop Smoking Services often fail to ask clients about underlying mental health problems and thus fail to put in place the treatment adaptations and liaison procedures often required to meet the needs of clients with a mental health condition who want to stop smoking. This study assesses the recording of mental health problems in a large NHS stop smoking service in England and examines the effect of implementing a short screening procedure on recording mental health conditions.</p> <p>Methods</p> <p>Treatment records from the Stop Smoking Service covering a period of 13 months were audited. The prevalence of reported mental health problems in the six month period before the implementation of the mental health screening procedure was compared with that of the six month period following implementation. The screening procedure was only implemented in the support services directly provided by the Stop Smoking Service. Comparisons were also made with third-party sections of the service where no such screening procedure was introduced.</p> <p>Results</p> <p>The prevalence of reported mental health problems among a total of n = 4999 clients rose from less than 1% before implementation of the screening procedure to nearly 12% in the period following implementation, with the change being statistically significant. No significant rise was observed over the same period in the sections of the service where no screening procedure was implemented.</p> <p>Conclusions</p> <p>The absence of standard procedures to record mental health problems among service users in many stop smoking services is currently likely to prevent the detection of co morbidity. Implementing a simple screening procedure appears suitable to increase the routine recording of mental health problems in a stop smoking service, which is an essential step to ensure services can be tailored and delivered appropriately to the client group.</p

Enteric helminths promote Salmonella co-infection by altering the intestinal metabolome

Intestinal helminth infections occur pre dominantly in regions where exposure to enteric bacterial pathogens is also common. Helminth infections inhibit host immunity against microbial pathogens, which has largely been attributed to the induction of regulatory or type 2 (Th2) immune responses. Here we demonstrate an additional three-way interaction in which helminth infection alters the metabolic environment of the host intestine to enhance bacterial pathogenicity. We show that an ongoing helminth infection increased colonization by Salmonella independently of T regulatory or Th2 cells. Instead, helminth infection altered the metabolic profile of the intestine, which directly enhanced bacterial expression of Salmonella pathogenicity island 1 (SPI-1) genes and increased intracellular invasion. These data reveal a novel mechanism by which a helminth-modified metabolome promotes susceptibility to bacterial co-infection

MMT Extremely Metal Poor Galaxy Survey I. An Efficient Technique to Identify Metal Poor Galaxies

We demonstrate a successful strategy for identifying extremely metal poor galaxies. Our preliminary survey of 24 candidates contains 10 metal poor galaxies of which 4 have 12+log(O/H)<7.65, some of the lowest metallicity blue compact galaxies known to date. Interestingly, our sample of metal poor galaxies have systematically lower metallicity for their luminosity than comparable samples of blue compact galaxies, dIrrs, and normal star-forming galaxies. Our metal poor galaxies share very similar properties, however, with the host galaxies of nearby long-duration gamma-ray bursts (GRBs), including similar metallicity, stellar ages, and star formation rates. We use H\beta to measure the number of OB stars present in our galaxies and estimate a core-collapse supernova rate of ~10^-3 yr^-1. A larger sample of metal poor galaxies may provide new clues into the environment where GRBs form and may provide a list of potential GRB hosts.Comment: Accepted to AJ, 8 pages using emulateap