3,441 research outputs found
A simple expression for the ADM mass
We show by an almost elementary calculation that the ADM mass of an
asymptotically flat space can be computed as a limit involving a rate of change
of area of a closed 2-surface. The result is essentially the same as that given
by Brown and York. We will prove this result in two ways, first by direct
calculation from the original formula as given by Arnowitt, Deser and Misner
and second as a corollary of an earlier result by Brewin for the case of
simplicial spaces.Comment: 9 pages, 1 figur
Demographics, diagnostics, treatment, and outcomes of patients presenting with acute groin hernia:15-year multicentre retrospective cohort study
The Panchromatic Hubble Andromeda Treasury II. Tracing the Inner M31 Halo with Blue Horizontal Branch Stars
We attempt to constrain the shape of M31's inner stellar halo by tracing the
surface density of blue horizontal branch (BHB) stars at galactocentric
distances ranging from 2 kpc to 35 kpc. Our measurements make use of resolved
stellar photometry from a section of the Panchromatic Hubble Andromeda Treasury
(PHAT) survey, supplemented by several archival Hubble Space Telescope
observations. We find that the ratio of BHB to red giant stars is relatively
constant outside of 10 kpc, suggesting that the BHB is as reliable a tracer of
the halo population as the red giant branch. In the inner halo, we do not
expect BHB stars to be produced by the high metallicity bulge and disk, making
BHB stars a good candidate to be a reliable tracer of the stellar halo to much
smaller galactocentric distances. If we assume a power-law profile r^(-\alpha)
for the 2-D projected surface density BHB distribution, we obtain a
high-quality fit with a 2-D power-law index of \alpha=2.6^{+0.3}_{-0.2} outside
of 3 kpc, which flattens to \alpha<1.2 inside of 3 kpc. This slope is
consistent with previous measurements but is anchored to a radial baseline that
extends much farther inward. Finally, assuming azimuthal symmetry and a
constant mass-to-light ratio, the best-fitting profile yields a total halo
stellar mass of 2.1^{+1.7}_{-0.4} x 10^9 M_sun. These properties are comparable
with both simulations of stellar halo formation formed by satellite disruption
alone, and with simulations that include some in situ formation of halo stars.Comment: 15 pages, 1 table, 5 figures, accepted for publication in Ap
A Recurrent Network in the Lateral Amygdala: A Mechanism for Coincidence Detection
Synaptic changes at sensory inputs to the dorsal nucleus of the lateral amygdala (LAd) play a key role in the acquisition and storage of associative fear memory. However, neither the temporal nor spatial architecture of the LAd network response to sensory signals is understood. We developed a method for the elucidation of network behavior. Using this approach, temporally patterned polysynaptic recurrent network responses were found in LAd (intra-LA), both in vitro and in vivo, in response to activation of thalamic sensory afferents. Potentiation of thalamic afferents resulted in a depression of intra-LA synaptic activity, indicating a homeostatic response to changes in synaptic strength within the LAd network. Additionally, the latencies of thalamic afferent triggered recurrent network activity within the LAd overlap with known later occurring cortical afferent latencies. Thus, this recurrent network may facilitate temporal coincidence of sensory afferents within LAd during associative learning
Focus, Vol. 1 No. 1
A literary magazine of student writing published by the Department of English of Stephen F. Austin State College.https://scholarworks.sfasu.edu/focus/1000/thumbnail.jp
The prognostic impact of pre-treatment cachexia in resectional surgery for oesophagogastric cancer:a meta-analysis and meta-regression
In the dedicated pursuit of dedicated capital: restoring an indigenous investment ethic to British capitalism
Tony Blair’s landslide electoral victory on May 1 (New Labour Day?) presents the party in power with a rare, perhaps even unprecedented, opportunity to revitalise and modernise Britain’s ailing and antiquated manufacturing economy.* If it is to do so, it must remain true to its long-standing (indeed, historic) commitment to restore an indigenous investment ethic to British capitalism. In this paper we argue that this in turn requires that the party reject the very neo-liberal orthodoxies which it offered to the electorate as evidence of its competence, moderation and ‘modernisation’, which is has internalised, and which it apparently now views as circumscribing the parameters of the politically and economically possible
Rare variants in optic disc area gene CARD10 enriched in primary open-angle glaucoma
Background: Genome-wide association studies (GWAS) have identified association of common alleles with primary open-angle glaucoma (POAG) and its quantitative endophenotypes near numerous genes. This study aims to determine whether rare pathogenic variants in these disease-associated genes contribute to POAG. Methods: Participants fulfilled strict inclusion criteria of advanced POAG at a young age of diagnosis. Myocilin mutation carriers were excluded using direct sequencing. Whole exome sequencing was performed on 187 glaucoma cases and 103 local screened nonglaucoma controls then joint-called with exomes of 993 previously sequenced Australian controls. GWAS-associated genes were assessed for enrichment of rare predicted pathogenic variants in POAG. Significantly enriched genes were compared against Exome Aggregation Consortium (ExAC) public control. Results: Eighty-six GWAS disease or trait-associated glaucoma genes were captured and sequenced. CARD10 showed enrichment after Bonferroni correction for rare variants in glaucoma cases (OR = 13.2, P = 6.94 × 10−5) with mutations identified in 4.28% of our POAG cohort compared to 0.27% in controls. CARD10 was significantly associated with optic disc parameters in previous GWAS. The whole GWAS gene set showed no enrichment in POAG overall (OR = 1.12, P = 0.51). Conclusion: We report here an enrichment of rare predicted pathogenic coding variants within a GWAS-associated locus in POAG (CARD10). These findings indicate that both common and rare pathogenic coding variants in CARD10 may contribute to POAG pathogenesis.Tiger Zhou, Emmanuelle Souzeau, Shiwani Sharma, Owen M. Siggs, Ivan Goldberg, Paul R. Healey, Stuart Graham, Alex W. Hewitt, David A. Mackey, Robert J. Casson, John Landers, Richard Mills, Jonathan Ellis, Paul Leo, Matthew A. Brown, Stuart MacGregor, Kathryn P. Burdon and Jamie E. Crai
Length of carotid stenosis predicts peri-procedural stroke or death and restenosis in patients randomized to endovascular treatment or endarterectomy.
BACKGROUND: The anatomy of carotid stenosis may influence the outcome of endovascular treatment or carotid endarterectomy. Whether anatomy favors one treatment over the other in terms of safety or efficacy has not been investigated in randomized trials.
METHODS: In 414 patients with mostly symptomatic carotid stenosis randomized to endovascular treatment (angioplasty or stenting; n = 213) or carotid endarterectomy (n = 211) in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), the degree and length of stenosis and plaque surface irregularity were assessed on baseline intraarterial angiography. Outcome measures were stroke or death occurring between randomization and 30 days after treatment, and ipsilateral stroke and restenosis ≥50% during follow-up. RESULTS: Carotid stenosis longer than 0.65 times the common carotid artery diameter was associated with increased risk of peri-procedural stroke or death after both endovascular treatment [odds ratio 2.79 (1.17-6.65), P = 0.02] and carotid endarterectomy [2.43 (1.03-5.73), P = 0.04], and with increased long-term risk of restenosis in endovascular treatment [hazard ratio 1.68 (1.12-2.53), P = 0.01]. The excess in restenosis after endovascular treatment compared with carotid endarterectomy was significantly greater in patients with long stenosis than with short stenosis at baseline (interaction P = 0.003). Results remained significant after multivariate adjustment. No associations were found for degree of stenosis and plaque surface.
CONCLUSIONS: Increasing stenosis length is an independent risk factor for peri-procedural stroke or death in endovascular treatment and carotid endarterectomy, without favoring one treatment over the other. However, the excess restenosis rate after endovascular treatment compared with carotid endarterectomy increases with longer stenosis at baseline. Stenosis length merits further investigation in carotid revascularisation trials
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