The State of Health Insurance in California: Findings from the 2005 California Health Interview Survey

Finds that eight in ten of the state's uninsured are employed, and that job-based health insurance coverage in California continues to decline

The diet of woodland caribou populations in west-central Alberta

The diet of woodland caribou (Rangifer tarandus caribou) populations in the foothills and Rocky Mountains of west-central Alberta was estimated by microhistological analyses of feces collected in winter and summer. In winter, terrestrial lichens averaged 60-83% of fecal fragment densities in both areas. In the mountains, decreasing proportions of terrestrial lichens and increasing proportions of conifer needles and moss indicated decreasing accessibility of forage because of deeper/harder snow. Apparent diets in summer were dominated by Salix spp., sedges, and lichens. However, forb inflorescences and stems were largely undetected by the microhistological technique and results for summer samples must be interpreted accordingly. We conclude that the conservation and management of forest ecotypes of caribou must include options of lichen-rich habitats as a major component of management plans

Nurses\u27 Alumnae Association Bulletin, June 1967

President\u27s Message Officers and Committee Chairman Financial Report Report to Alumnae Association Nursing Service Report Operating Room Report School of Practical Nursing Report School of Nursing Report President Herbert\u27s Address (abstracted) Report from Africa Student Activities Nursing Service Staff Association Resume of Alumnae Meetings Way and Means Report Social Committee Building Fund Report Class News Notice

2'-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA.

Electron paramagnetic resonance (EPR) spectroscopy is a powerful method to elucidate molecular structure through the measurement of distances between conformationally well-defined spin labels. Here we report a sequence-flexible approach to the synthesis of double spin-labeled DNA duplexes, where 2'-alkynylnucleosides are incorporated at terminal and internal positions on complementary strands. Post-DNA synthesis copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with a variety of spin labels enable the use of double electron-electron resonance experiments to measure a number of distances on the duplex, affording a high level of detailed structural information

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

Funding: Engineering and Physical Sciences Research Council [EP/M019195/1]; Engineering and Physical Sciences Research Council Studentship (to J.S.H.); Biotechnology and Biological Sciences Research Council [BB/J001694/2, BB/R021848/1]; ADTBio; University of Kentucky and NCI Cancer Center Support Grant [P30 CA177558]; The Carmen L. Buck Endowment; Emerging Fields Initiative of the Friedrich-Alexander-University of Erlangen-Nuremberg [Grant title ‘Chemistry in Live Cells’]; Wellcome Trust [099149/Z/12/Z]; Royal Society, University Research Fellowship (to J.E.L.). Funding for open access charge: University of Oxford.The determination of distances between specific points in nucleic acids is essential to understanding their behaviour at the molecular level. The ability to measure distances of 2–10 nm is particularly important: deformations arising from protein binding commonly fall within this range, but the reliable measurement of such distances for a conformational ensemble remains a significant challenge. Using several techniques, we show that electron paramagnetic resonance (EPR) spectroscopy of oligonucleotides spin-labelled with triazole-appended nitroxides at the 2′ position offers a robust and minimally perturbing tool for obtaining such measurements. For two nitroxides, we present results from EPR spectroscopy, X-ray crystal structures of B-form spin-labelled DNA duplexes, molecular dynamics simulations and nuclear magnetic resonance spectroscopy. These four methods are mutually supportive, and pinpoint the locations of the spin labels on the duplexes. In doing so, this work establishes 2′-alkynyl nitroxide spin-labelling as a minimally perturbing method for probing DNA conformation.Publisher PDFPeer reviewe

Reviews

The Christian Goddess: Archetype and Theology in the Fantasies of George MacDonald. Bonnie Gaarden. Reviewed by Scott McLaren. Picturing Tolkien: Essays on Peter Jackson\u27s The Lord of the Rings Film Trilogy. Janice M. Bogstad and Philip E. Kaveny, eds. Reviewed by Emily E. Auger. Good Dragons are Rare: An Inquiry into Literary Dragons East and West. Fanfan Chen and Thomas Honegger, eds. Reviewed by David D. Oberhelman. Critical Perspectives on Philip Pullman\u27s His Dark Materials: Essays on the Novels, the Film and the Stage Productions. Steven Barfield and Katharine Cox, eds. Reviewed by Amy S. Rodgers. From Elvish to Klingon: Exploring Invented Languages. Michael Adams, ed. Reviewed by Harley J. Sims. Mythopoeic Narnia: Memory, Metaphor, and Metamorphoses in The Chronicles of Narnia. Salwa Khoddam. Reviewed by Holly Ordway. Abiding in the Sanctuary: The Waite-Trinick Tarot: A Christian Mystical Tarot (1917-1923). Tali Goodwin and Marcus Katz. Preface by Mary K. Greer. Reviewed by Emily E. Auger. Tolkien and Wales: Language, Literature, and Identity. Carl Phelpstead. Reviewed by Sara Brown. North Wind: A Journal of George MacDonald Studies. #29 (2010). Edited by Fernando Soto and John Pennington. Reviewed by Janet Brennan Croft. VII: An Anglo-American Literary Review. #28 (2011). Edited by Marjorie Lamp Mead et al. Reviewed by Janet Brennan Croft. Tolkien Studies: An Annual Scholarly Review. #8 (2011). Edited by Douglas A. Anderson, Michael D.C. Drout, and Verlyn Flieger. Reviewed by Janet Brennan Croft

Coupled land use and ecological models reveal emergence and feedbacks in socio-ecological systems

Acknowledgements: This work was supported by an EPSRC Doctoral Training Centre grant (EP/G03690X/1). Supplementary material (Appendix ECOG‐04039 at ). Appendix 1.Peer reviewedPublisher PD

Patterns of Natural and Human-Caused Mortality Factors of a Rare Forest Carnivore, the Fisher (Pekania pennanti) in California.

Wildlife populations of conservation concern are limited in distribution, population size and persistence by various factors, including mortality. The fisher (Pekania pennanti), a North American mid-sized carnivore whose range in the western Pacific United States has retracted considerably in the past century, was proposed for threatened status protection in late 2014 under the United States Endangered Species Act by the United States Fish and Wildlife Service in its West Coast Distinct Population Segment. We investigated mortality in 167 fishers from two genetically and geographically distinct sub-populations in California within this West Coast Distinct Population Segment using a combination of gross necropsy, histology, toxicology and molecular methods. Overall, predation (70%), natural disease (16%), toxicant poisoning (10%) and, less commonly, vehicular strike (2%) and other anthropogenic causes (2%) were causes of mortality observed. We documented both an increase in mortality to (57% increase) and exposure (6%) from pesticides in fishers in just the past three years, highlighting further that toxicants from marijuana cultivation still pose a threat. Additionally, exposure to multiple rodenticides significantly increased the likelihood of mortality from rodenticide poisoning. Poisoning was significantly more common in male than female fishers and was 7 times more likely than disease to kill males. Based on necropsy findings, suspected causes of mortality based on field evidence alone tended to underestimate the frequency of disease-related mortalities. This study is the first comprehensive investigation of mortality causes of fishers and provides essential information to assist in the conservation of this species