1,245 research outputs found
Finitely generated soluble groups and their subgroups
We prove that every finitely generated soluble group which is not virtually
abelian has a subgroup of one of a small number of types.Comment: 16 page
Effects of Technology Based Interactive Multimedia on Training of Laminators at General Dynamics Armament & Technical Products Manufacturing
To guide this study, the following hypothesis was established: For skin laminators working in the clean room at General Dynamics Armament & Technical Products, traditional methods of training, in conjunction with technology based interactive multimedia, will result in an increase in retention over a longer period of time with less direct human training needed
The Properties of Brightest Cluster Galaxies in X-Ray Selected Clusters
We present the K-band Hubble diagram for 162 brightest cluster galaxies
(BCGs) in X-ray selected clusters, 0.01<z<0.83. The sample incorporates that of
Burke, Collins, & Mann (2000) and includes additional infrared data from the
2MASS extended source catalogue. We show that below z=0.1 the BCGs show no
correlation with their environment, however, above z=0.1 BCGs in more X-ray
luminous clusters are more uniform in their photometric properties. This
suggests that there may be two populations of BCGs which have different
evolutionary histories.Comment: 2 pages, to appear in the proceedings of the Sesto 2001 conference on
tracing cosmic evolution with galaxy cluster
Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy
Dysregulated inflammation contributes to disease pathogenesis in both the periphery and the brain. Cytokines are coordinators of inflammation and were originally defined as secreted mediators, released from expressing cells to activate plasma membrane receptors on responsive cells. However, a group of cytokines is now recognized as having dual functionality. In addition to their extracellular effects, these cytokines act inside the nuclei of cytokine-expressing or cytokine-responsive cells. Interleukin-1 (IL-1) family cytokines are key pro-inflammatory mediators, and blockade of the IL-1 system in inflammatory diseases is an attractive therapeutic goal. All current therapies target IL-1 extracellular actions. Here we review evidence that suggests IL-1 family members have dual functionality. Several IL-1 family members have been detected inside the nuclei of IL-1-expressing or IL-1-responsive cells, and intranuclear IL-1 is reported to regulate gene transcription and mRNA splicing. However, further work is required to determine the impact of IL-1 intranuclear actions on disease pathogenesis. The intranuclear actions of IL-1 family members represent a new and potentially important area of IL-1 biology and may have implications for the future development of anti-IL-1 therapies
Long-term stability of fibre-optic transmission for multi-object spectroscopy
We present an analysis of the long-term stability of fibre-optic transmission properties for fibre optics in astronomy. Data from 6 years of operation of the AAOmega multi-object spectrograph at the Anglo-Australian Telescope are presented. We find no evidence for significant degradation in the bulk transmission properties of the 38-m optical fibre train. Significant losses (<20 per cent relative, 4 per cent absolute) are identified and associated with the end termination of the optical fibres in the focal plane. Improved monitoring and maintenance can rectify the majority of this performance degradation
An adaptive threshold determination method of feature screening for genomic selection
Background Although the dimension of the entire genome can be extremely large, only a parsimonious set of influential SNPs are correlated with a particular complex trait and are important to the prediction of the trait. Efficiently and accurately selecting these influential SNPs from millions of candidates is in high demand, but poses challenges. We propose a backward elimination iterative distance correlation (BE-IDC) procedure to select the smallest subset of SNPs that guarantees sufficient prediction accuracy, while also solving the unclear threshold issue for traditional feature screening approaches.
Results Verified through six simulations, the adaptive threshold estimated by the BE-IDC performed uniformly better than fixed threshold methods that have been used in the current literature. We also applied BE-IDC to an Arabidopsis thaliana genome-wide data. Out of 216,130 SNPs, BE-IDC selected four influential SNPs, and confirmed the same FRIGIDA gene that was reported by two other traditional methods.
Conclusions BE-IDC accommodates both the prediction accuracy and the computational speed that are highly demanded in the genomic selection
How young people from culturally and linguistically diverse backgrounds experience mental health: some insights for mental health nurses
This article reports on a part of a study which looked at the mental health of
culturally and linguistically diverse (CALD) young people. The research sought to learn
from CALD young people, carers, and service providers experiences relevant to the
mental health of this group of young people. The ultimate goal was to gain insights that
would inform government policy, service providers, ethnic communities and most
importantly the young people themselves. To this end, qualitative interviews were
undertaken with 123 CALD young people, 41 carers and 14 mental health service
providers in Queensland, Western Australia and South Australia.
Only one aspect of the study will be dealt with here, namely the views of the
young CALD participants, which included risk factors, coping strategies and
recommendations about how they could be supported in their struggle to maintain
mental health. One of the most important findings of the study relates to the resilience
of these young people and an insight into the strategies that they used to cope. The
efforts of these young people to assist us in our attempts to understand their situation
deserve to be rewarded by improvements in the care that we provide. To this end this
article sets out to inform mental health nurses of the results of the study so that they will
be in a position to better understand the needs and strengths of their CALD clients and
be in a better position to work effectively with them
Kinetic analysis of copper(I)/feringa-phosphoramidite catalysed AlEt3 1,4-addition to cyclohex-2-en-1-one
ReactIR studies of mixtures of AlEt3 (A) and cyclohex-2-en-1-one (CX) in Et2O indicate immediate formation of the Lewis acid-base complex (CX.A) at -40 oC (K = 12.0 M-1, ΔGo react -1.1 kcal mol-1). Copper(I) catalysts, derived from pre-catalytic Cu(OAc)2 (up to 5 mol- %) and (R,S,S)-P(binaphtholate){N(CHMePh)2} [Feringa’s ligand (L), up to 5 mol-%] convert CX.A (0.04-0.3 M) into its 1,4-addition product enolate (E) within 2000 sec at -40 oC. Kinetic studies (ReactIR and chiral GC) of CX.A, CX and (R)-3-ethylcyclohexanone (P, the H+ quench product of enolate E) show that the true catalyst is formed in the first 300 sec and this subsequently provides P in 82% ee. This true catalyst converts CX.A to E with a rate law [Cu]1.5[L]0.66[CX.A]1 when [L]/[Cu] ≤ 3.5. Above this ligand ratio inhibition by added ligand with order [L]-2.5 is observed. A rate determining step (rds) of Cu3L2(CX.A)2 stoichiometry is shown to be most consistent with the rate law. The presence of the enolate in the active catalyst (Graphical Abstract) best accounts for the reaction’s induction period and molecularity as [E] ≡ [CX.A]. Catalysis proceeds through a ‘shuttling mechanism’ between two C2 symmetry related ground state intermediates. Each turnover consumes one equivalent of CX.A, expels one molecule of E and forms the new Cu-Et bond needed for the next cycle (Graphic Abstract). The observed ligand (L) inhibition and a non-linear ligand Lee effect on the ee of P are all well simulated by the kinetic model. DFT studies [ωB97X-D/SRSC] support coordination of CX.A to the groundstate Cu-trimer and its rapid conversion to E
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