Customising games for non-formal rehabilitation

The field of rehabilitation has increasingly adopted commercially available games using perceptual interfaces as a means for physically training patients. The adaptability of such systems to match each person’s need and rehabilitation goal remains problematic. This paper presents a rapid prototyping approach for customising gaming technology using various affordable commercial devices and open source software. We first demonstrate how a freely available game is adapted for training disabled people through different sensors and control modes. We then show how an open online virtual world such as Second Life® offers sufficient conditions for quickly building custom content for testing with interactive devices. When presented with these prototyping possibilities, people from the target groups (healthcare professionals, patients, people with disabilities, older people, families) related such systems to their needs and further elaborated on the use of such systems. Our research indicates how availability of simple prototyping platforms expands upon the possibilities for developers and practitioners

The NNLO non-singlet QCD analysis of parton distributions based on Bernstein polynomials

A non-singlet QCD analysis of the structure function $xF_3$ up to NNLO is performed based on the Bernstein polynomials approach. We use recently calculated NNLO anomalous dimension coefficients for the moments of the $xF_3$ structure function in $\nu N$ scattering. In the fitting procedure, Bernstein polynomial method is used to construct experimental moments from the $xF_3$ data of the CCFR collaboration in the region of $x$ which is inaccessible experimentally. We also consider Bernstein averages to obtain some unknown parameters which exist in the valence quark densities in a wide range of $x$ and $Q^2$. The results of valence quark distributions up to NNLO are in good agreement with the available theoretical models. In the analysis we determined the QCD-scale $\Lambda^ {\bar{MS}}_{QCD, N_{f}=4}=211$ MeV (LO), 259 MeV (NLO) and 230 MeV (NNLO), corresponding to $\alpha_s(M_Z^2)=0.1291$ LO, $\alpha_s(M_Z^2)=0.1150$ NLO and $\alpha_s(M_Z^2)=0.1142$ NNLO. We compare our results for the QCD scale and the $\alpha_s(M_Z^2)$ with those obtained from deep inelastic scattering processes.Comment: 20 pages, 7 figures, published in JHE

Open-Ended Evolutionary Robotics: an Information Theoretic Approach

This paper is concerned with designing self-driven fitness functions for Embedded Evolutionary Robotics. The proposed approach considers the entropy of the sensori-motor stream generated by the robot controller. This entropy is computed using unsupervised learning; its maximization, achieved by an on-board evolutionary algorithm, implements a "curiosity instinct", favouring controllers visiting many diverse sensori-motor states (sms). Further, the set of sms discovered by an individual can be transmitted to its offspring, making a cultural evolution mode possible. Cumulative entropy (computed from ancestors and current individual visits to the sms) defines another self-driven fitness; its optimization implements a "discovery instinct", as it favours controllers visiting new or rare sensori-motor states. Empirical results on the benchmark problems proposed by Lehman and Stanley (2008) comparatively demonstrate the merits of the approach

Entanglement and entropy operator for strings in pp-wave time dependent background

In this letter new aspects of string theory propagating in a pp-wave time dependent background with a null singularity are explored. It is shown the appearance of a 2d entanglement entropy dynamically generated by the background. For asymptotically flat observers, the vacuum close to the singularity is unitarily inequivalent to the vacuum at $\tau = -\infty$ and it is shown that the 2d entanglement entropy diverges close to this point. As a consequence, the positive time region is inaccessible for observers in $\tau =-\infty$. For a stationary measure, the vacuum at finite time is seen by those observers as a thermal state and the information loss is encoded as a heat bath of string states.Comment: revtex4, 15 pages, revised version to appear in Physics Letters

Observer dependent D-brane for strings propagating in pp-wave time dependent background

We study type IIB superstring in the pp-wave time-dependent background, which has a singularity at $t=0$. We show that this background can provide a toy model to study some ideas related to the stretched horizon paradigm and the complementary principle of black holes. To this end, we construct a unitary Bogoliubov generator which relates the asymptotically flat string Hilbert space, defined at $t =\pm \infty$, to the finite time Hilbert space. For asymptotically flat observers, the closed string vacuum close to the singularity appears as a boundary state which is in fact a D-brane described in the closed string channel. However, observers who go with the string towards to the singularity see the original vacuum.Comment: 12 pages, revtex 4, added references, corrected mistake

Identification of functionally distinct macrophage subpopulations in Drosophila

Vertebrate macrophages are a highly heterogeneous cell population, but while Drosophila blood is dominated by a macrophage-like lineage (plasmatocytes), until very recently these cells were considered to represent a homogeneous population. Here, we present our identification of enhancer elements labelling plasmatocyte subpopulations, which vary in abundance across development. These subpopulations exhibit functional differences compared to the overall population, including more potent injury responses and differential localisation and dynamics in pupae and adults. Our enhancer analysis identified candidate genes regulating plasmatocyte behaviour: pan-plasmatocyte expression of one such gene (Calnexin14D) improves wound responses, causing the overall population to resemble more closely the subpopulation marked by the Calnexin14D-associated enhancer. Finally, we show that exposure to increased levels of apoptotic cell death modulates subpopulation cell numbers. Taken together this demonstrates macrophage heterogeneity in Drosophila, identifies mechanisms involved in subpopulation specification and function and facilitates the use of Drosophila to study macrophage heterogeneity in vivo

High frequency resonant experiments in Fe8_8 molecular clusters

Precise resonant experiments on Fe$_{8}$ magnetic clusters have been conducted down to 1.2 K at various tranverse magnetic fields, using a cylindrical resonator cavity with 40 different frequencies between 37 GHz and 110 GHz. All the observed resonances for both single crystal and oriented powder, have been fitted by the eigenstates of the hamiltonian ${\cal H}=-DS_z^2+ES_x^2-g\mu_B{\bf H}\cdot {\bf S}$. We have identified the resonances corresponding to the coherent quantum oscillations for different orientations of spin S = 10.Comment: to appear in Phys.Rev. B (August 2000

Epistemic and social scripts in computer-supported collaborative learning

Collaborative learning in computer-supported learning environments typically means that learners work on tasks together, discussing their individual perspectives via text-based media or videoconferencing, and consequently acquire knowledge. Collaborative learning, however, is often sub-optimal with respect to how learners work on the concepts that are supposed to be learned and how learners interact with each other. One possibility to improve collaborative learning environments is to conceptualize epistemic scripts, which specify how learners work on a given task, and social scripts, which structure how learners interact with each other. In this contribution, two studies will be reported that investigated the effects of epistemic and social scripts in a text-based computer-supported learning environment and in a videoconferencing learning environment in order to foster the individual acquisition of knowledge. In each study the factors ‘epistemic script’ and ‘social script’ have been independently varied in a 2×2-factorial design. 182 university students of Educational Science participated in these two studies. Results of both studies show that social scripts can be substantially beneficial with respect to the individual acquisition of knowledge, whereas epistemic scripts apparently do not to lead to the expected effects

Hydrophobic and ionic-interactions in bulk and confined water with implications for collapse and folding of proteins

Water and water-mediated interactions determine thermodynamic and kinetics of protein folding, protein aggregation and self-assembly in confined spaces. To obtain insights into the role of water in the context of folding problems, we describe computer simulations of a few related model systems. The dynamics of collapse of eicosane shows that upon expulsion of water the linear hydrocarbon chain adopts an ordered helical hairpin structure with 1.5 turns. The structure of dimer of eicosane molecules has two well ordered helical hairpins that are stacked perpendicular to each other. As a prelude to studying folding in confined spaces we used simulations to understand changes in hydrophobic and ionic interactions in nano droplets. Solvation of hydrophobic and charged species change drastically in nano water droplets. Hydrophobic species are localized at the boundary. The tendency of ions to be at the boundary where water density is low increases as the charge density decreases. Interaction between hydrophobic, polar, and charged residue are also profoundly altered in confined spaces. Using the results of computer simulations and accounting for loss of chain entropy upon confinement we argue and then demonstrate, using simulations in explicit water, that ordered states of generic amphiphilic peptide sequences should be stabilized in cylindrical nanopores

Semiconductive and Photoconductive Properties of the Single Molecule Magnets Mn12_{12}-Acetate and Fe8_8Br8_8

Resistivity measurements are reported for single crystals of Mn$_{12}$-Acetate and Fe$_8$Br$_8$. Both materials exhibit a semiconductor-like, thermally activated behavior over the 200-300 K range. The activation energy, $E_a$, obtained for Mn$_{12}$-Acetate was 0.37 $\pm$ 0.05 eV, which is to be contrasted with the value of 0.55 eV deduced from the earlier reported absorption edge measurements and the range of 0.3-1 eV from intramolecular density of states calculations, assuming $2E_a$= $E_g$, the optical band gap. For Fe$_8$Br$_8$, $E_a$ was measured as 0.73 $\pm$ 0.1 eV, and is discussed in light of the available approximate band structure calculations. Some plausible pathways are indicated based on the crystal structures of both lattices. For Mn$_{12}$-Acetate, we also measured photoconductivity in the visible range; the conductivity increased by a factor of about eight on increasing the photon energy from 632.8 nm (red) to 488 nm (blue). X-ray irradiation increased the resistivity, but $E_a$ was insensitive to exposure.Comment: 7 pages, 8 figure