Health-Related Quality of Life, Mental Health and Psychotherapeutic Considerations for Women Diagnosed with a Disorder of Sexual Development: Congenital Adrenal Hyperplasia

Little is known about the long-term health-related quality of life (HRQL) and mental health outcomes for women diagnosed with congenital adrenal hyperplasia (CAH), a disorder of sex development. Though recommendations for therapists exist, no research has empirically investigated women's experiences in therapy or their recommendations for therapy. Thus the purpose of the study was to investigate HRQL, mental health concerns of women with CAH, and patients' recommendations for therapists. A qualitative methodology, consensual qualitative research, was used to answer these questions. Eight women with CAH participated in the study. Results from their interviews revealed six domains: physical functioning, psychological functioning, interpersonal processes and relationships, healthcare experiences of women with CAH, recommendations for health care professionals, and systemic considerations. Domains were further broken down into categories with results yielding implications for both medical and mental health professionals and shedding light on issues related to normalcy, concerns both related and unrelated to CAH, sex, and gender, and highlighting effective supports and therapeutic interventions

Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis

Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs

Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc : ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth

The opportunistic mycopathogen Aspergillus fumigatus expresses both glucosylceramide and galactosylceramide (GlcCer and GalCer), but their functional significance in Aspergillus species is unknown. We here identified and characterized a GlcCer from Aspergillus nidulans, a non-pathogenic model fungus. Involvement of GlcCer in fungal development was tested on both species using a family of compounds known to inhibit GlcCer synthase in mammals. Two analogs, D-threo-1-phenyl-2-palmitoyl-3-pyrrolidinopropanol (P4) and D-threo-3',4'-ethylenedioxy-P4, strongly inhibited germination and hyphal growth. Neutral lipids from A. fumigatus cultured in the presence of these inhibitors displayed a significantly reduced GlcCer/GalCer ratio. These results suggest that synthesis of GlcCer is essential for normal development of A. fumigatus and A. nidulans. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.Univ New Hampshire, Dept Chem, Durham, NH 03824 USAUniv Georgia, Dept Bot, Athens, GA 30602 USAUniversidade Federal de São Paulo, Dept Biochem, Escola Paulista Med, BR-04023900 São Paulo, BrazilUniv Michigan, Med Ctr, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USAUniv Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USAUniv Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USAUniversidade Federal de São Paulo, Dept Biochem, Escola Paulista Med, BR-04023900 São Paulo, BrazilWeb of Scienc

The Grizzly, January 27, 2005

Ashley Lynn McCaleb: Scholar, Daughter, Friend • I Want to be Made Into an RA • Students Take Action at the Presidential Inauguration • New Member Education Returns • Fatal Blow • Myrin Undergoes Major Changes • Tsunami Relief Efforts Taking Shape at Ursinus • Ursinus Students Make Requests for The Facebook • Opinions: Is Mother Nature Trying to Tell us Something?; Bush\u27s New Cabinet Appointments may not be the Wisest • Bears Battling Without Stanton • Dedication and Attitude Forms a True Competitorhttps://digitalcommons.ursinus.edu/grizzlynews/1575/thumbnail.jp

The Grizzly, April 15, 2004

Ursinus College Commencement Only One Month Away • Taking Our Place Campaign • Meet This Year\u27s Valedictorians • Silence Makes a Statement • Opinions: Make a Statement with Silence; Class of 2004 Campaigns Hard!; Hyped About Housing; Higher Gas Prices = Economical Cars • Faculty Spotlight: Houghton Kane • Chess Club Results • Who\u27s Who at Ursinus • Softball Team Continues to Shut Down Opponents • Ursinus Outdoor Track and Field: Experience for a Young Team • Baseball Team Trying to be a Contender • Grimmel, Furman Earn All-American Honors at NCGA Championships • Durkin Named CC Player of the Weekhttps://digitalcommons.ursinus.edu/grizzlynews/1559/thumbnail.jp

The Grizzly, September 5, 2002

143 Students Call Richter / North Hall Home • Under Construction Again: Field House Floor to be Redone • Orientation 2002 a Success for Freshmen and OAs • Bridge Program Unique and Important at Ursinus • Y100 at Ursinus • Freshmen Give Three Thumbs Up to Their So-Called Overcrowded Rooms • Opinions: Dirty Rooms Make Move-in Extra Grungy; What\u27s it Liked to be Named Bart?; Enemy Combatant Declarations: Wrong Policy for America • Bored? Get Some Brotherly Love in Your Life • Comparative Pricing Report: Snack Foods • Field Hockey Makes a Move to Centennial Conference • X-Country Boys and Girls Ranked 8th in Conference • Volleyball Jumps Out to Positive Start • Men\u27s Soccer Regroups with New Coach • Women\u27s Soccer go 2-0 in First Weekend of Play • Bearcock\u27s Rugby Returns for Second Season • Football Team Prepares for big Season Opener Against Washington & Jefferson • Roller Hockey Club to Play in PCRHL • Dougherty Sets Course Record in Brian Dennis Memorial X-Country Meethttps://digitalcommons.ursinus.edu/grizzlynews/1517/thumbnail.jp

Predicting functional responses in agro-ecosystems from animal movement data to improve management of invasive pests

Functional responses describe how changing resource availability affects con- sumer resource use, thus providing a mechanistic approach to prediction of the invasibility and potential damage of invasive alien species (IAS). However, functional responses can be context dependent, varying with resource characteristics and availability, consumer attributes, and environmental variables. Identifying context dependencies can allow invasion and damage risk to be predicted across different ecoregions. Understanding how ecological factors shape the functional response in agro-ecosystems can improve predictions of hotspots of highest impact and inform strategies to mitigate damage across locations with varying crop types and avail- ability. We linked heterogeneous movement data across different agro-ecosystems to predict ecologically driven variability in the functional responses. We applied our approach to wild pigs (Sus scrofa), one of the most successful and detrimental IAS worldwide where agricultural resource depredation is an important driver of spread and establishment. We used continental- scale movement data within agro-ecosystems to quantify the functional response of agricul- tural resources relative to availability of crops and natural forage. We hypothesized that wild pigs would selectively use crops more often when natural forage resources were low. We also examined how individual attributes such as sex, crop type, and resource stimulus such as dis- tance to crops altered the magnitude of the functional response. There was a strong agricul- tural functional response where crop use was an accelerating function of crop availability at low density (Type III) and was highly context dependent. As hypothesized, there was a reduced response of crop use with increasing crop availability when non-agricultural resources were more available, emphasizing that crop damage levels are likely to be highly heterogeneous depending on surrounding natural resources and temporal availability of crops. We found sig- nificant effects of crop type and sex, with males spending 20% more time and visiting crops 58% more often than females, and both sexes showing different functional responses depend- ing on crop type. Our application demonstrates how commonly collected animal movement data can be used to understand context dependencies in resource use to improve our under- standing of pest foraging behavior, with implications for prioritizing spatiotemporal hotspots of potential economic loss in agro-ecosystems

The Grizzly, September 12, 2002

America. No Longer the Beautiful • September 11, 2002: A Changed Nation Remembers • Omwake Party Closed for Overcrowding • The Dangers of Limerick: KI Pills Soon • The Freshman Fifteen: A Preventable Phenomenon for Students • Opinions: Too Much Liberty in Calling it a Diner; Zack\u27s Without the Power; Orientation Evaluation; New Laundry Detergent Testing: Bad Idea! • Remembering September 11th: Student Essays • September 11th: A National Holiday? I Think Not • Theater Booming at Ursinus • WVOU: Ursinus\u27 Pride and Joy • Redline Visits Ursinus • Comparative Pricing Report: Healthy Foods • Volleyball Crushes Albright College • Ursinus Looks to Next Game After Loss to W&J • Field Hockey Wins Season Opener • Women\u27s Soccer Loses Back-to-back in OThttps://digitalcommons.ursinus.edu/grizzlynews/1518/thumbnail.jp