630 research outputs found
Diagnostiek van mogelijk cardiale klachten door de huisarts : een evaluatie van diagnostische hulp in de vorm van electrocardiografie en serumenzymbepalingen
De onderhavige studie is een onderzoek naar de toepasbaarheid van een
dergelijke diagnostische hulpdienst op grote schaal (Rotterdam, Capelle
aan den !Jssel en Krimpen aan den !Jssel ). Het project kreeg de oorspronkelijke
naam 'Town of Rotterdam Acute Coronary Events' (TRACE).
Deze naam suggereert mogelijk dat hiermee alle 1acute coronaire episoden'
(acuut myocard infarct of plotse dood) in Rotterdam gedurende een bepaalde
periode worden bedoeld, doch dit is onjuist. De hulpdienst is bedoeld
voor mensen met nieuwe of veranderde klachten, waarbij de huisarts denkt
aan een ischaemische hartziekte en belang hecht aan uitslag van diagnostische
hulp dezelfde dag, doch waarvoor hij in eerste instantie géén
direkte opname noodzakelijk acht. Met nadruk wordt gesteld dat de hulpdienst
geen alternatief is voor een opname, wanneer dit in eerste instantie
noodzakelijk wordt geacht. De vraagstellingen van het onderzoek
luiden als volgt:
Is de hulpdienst praktisch uitvoerbaar;
Voorziet de hulpdienst in een behoefte;
Brengt de hulpdien st een gerichte be 1 ei dsveranderi ng teweeg, die de
behandeling van de patient verbetert;
Brengt het inroepen van de hulpdienst een onaanvaardbaar risico voor
de patient met zich mee;
Welke zijn de financiële kosten.
New dynamics in cerebellar Purkinje cells: torus canards
We describe a transition from bursting to rapid spiking in a reduced
mathematical model of a cerebellar Purkinje cell. We perform a slow-fast
analysis of the system and find that -- after a saddle node bifurcation of
limit cycles -- the full model dynamics follow temporarily a repelling branch
of limit cycles. We propose that the system exhibits a dynamical phenomenon new
to realistic, biophysical applications: torus canards.Comment: 4 pages; 4 figures (low resolution); updated following peer-review:
language and definitions updated, Figures 1 and 4 updated, typos corrected,
references added and remove
The supportive effects of IL-7 on eosinophil progenitors from human bone marrow cells can be blocked by anti-IL-5
Human rIL-7 was studied for its effects on myeloid and erythroid progenitors from human bone marrow cells. IL-7 did not support the granulocytic/monocytic or erythroid lineage but exclusively stimulated eosinophil colony formation (CFU-Eo) (4 ± 3 vs 48 ± 17 CFU-Eo/105 nonadherent fraction-non-T cell (NAF-NT) cells). This supportive effect was not mediated by T cells or monocytes because similar results were obtained with or without T cell or adherent depleted cell fractions. In addition, it was shown that CD34+ sorted cells could be stimulated by IL-7 (0 vs 15 ± 9 CFU-Eo/3 x 103 CD34+ cells). Furthermore studies with IL-3 or granulocyte- macrophage CSF (GM-CSF) demonstrated an additive effect on the IL-7 supported colony formation. Finally, experiments were performed with anti-IL-3, anti- GM-CSF, anti-IL-1, and anti-IL-5 to exclude the possibility that IL-7 indirectly stimulated the eosinophil progenitor cell. Anti-GM-CSF, anti-IL-1, or anti-IL-3 did not influence the supportive effects of IL-7. However, anti- IL-5 did abolish the effects of IL-7 on the eosinophil colony formation (69 ± 15 vs 3 ± 2 CFU-Eo/105 NAF-NT, n = 3). Similar results were obtained with CD34+ sorted cells. Moreover, IL-5 mRNA expression could be demonstrated in IL-7-stimulated NAF-NT cells. These data suggest that the supportive effects of IL-7 on eosinophil precursors are mediated by the endogenous release of IL-5.</p
Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells
Peer reviewedPublisher PD
Search for the exotic Resonance in 340GeV/c -Nucleus Interactions
We report on a high statistics search for the resonance in
-nucleus collisions at 340GeV/c. No evidence for this resonance is
found in our data sample which contains 676000 candidates above
background. For the decay channel and the
kinematic range 0.150.9 we find a 3 upper limit for the
production cross section of 3.1 and 3.5 b per nucleon for reactions with
carbon and copper, respectively.Comment: 5 pages, 4 figures, modification of ref. 43 and 4
Can Google search Data help predict macroeconomic series?
We make use of Google search data in an attempt to predict unemployment, CPI and consumer confidence for the US, UK, Canada, Germany and Japan. Google search queries have previously proven valuable in predicting macroeconomic variables in an in-sample context. However, to the best of our knowledge, the more challenging question of whether such data have out-of-sample predictive value has not yet been answered satisfactorily. We focus on out-of-sample nowcasting, and extend the Bayesian structural time series model using the Hamiltonian sampler for variable selection. We find that the search data retain their value in an out-of-sample predictive context for unemployment, but not for CPI or consumer confidence. It is possible that online search behaviours are a relatively reliable gauge of an individual’s personal situation (employment status), but less reliable when it comes to variables that are unknown to the individual (CPI) or too general to be linked to specific search terms (consumer confidence)
Measurement of the Omega_c Lifetime
We present the measurement of the lifetime of the Omega_c we have performed
using three independent data samples from two different decay modes. Using a
Sigma- beam of 340 GeV/c we have obtained clean signals for the Omega_c
decaying into Xi- K- pi+ pi+ and Omega- pi+ pi- pi+, avoiding topological cuts
normally used in charm analysis. The short but measurable lifetime of the
Omega_c is demonstrated by a clear enhancement of the signals at short but
finite decay lengths. Using a continuous maximum likelihood method we
determined the lifetime to be tau(Omega_c) = 55 +13-11(stat) +18-23(syst) fs.
This makes the Omega_c the shortest living weakly decaying particle observed so
far. The short value of the lifetime confirms the predicted pattern of the
charmed baryon lifetimes and demonstrates that the strong interaction plays a
vital role in the lifetimes of charmed hadrons.Comment: 15 pages, including 7 figures; gzipped, uuencoded postscrip
Beam-Induced Nuclear Depolarisation in a Gaseous Polarised Hydrogen Target
Spin-polarised atomic hydrogen is used as a gaseous polarised proton target
in high energy and nuclear physics experiments operating with internal beams in
storage rings. When such beams are intense and bunched, this type of target can
be depolarised by a resonant interaction with the transient magnetic field
generated by the beam bunches. This effect has been studied with the HERA
positron beam in the HERMES experiment at DESY. Resonances have been observed
and a simple analytic model has been used to explain their shape and position.
Operating conditions for the experiment have been found where there is no
significant target depolarisation due to this effect.Comment: REVTEX, 6 pages, 5 figure
Desmopressin for bleeding in non-severe hemophilia A:Suboptimal use in a real-world setting
Background Desmopressin is an important treatment option in nonsevere hemophilia A because it has several benefits compared with factor (F) concentrates, including no inhibitor risk and much lower costs. Despite these advantages, data are limited on the real-world use of desmopressin in the treatment of bleeds. Objective To describe the clinical use of desmopressin in relation to other therapeutic modalities in the treatment of bleeding episodes in patients with nonsevere hemophilia A. Methods Patients with nonsevere hemophilia A aged 12-55 years were included from the DYNAMO cohort study. Data on the desmopressin test response and treated bleeding events in the period January 2009 to July 2020 were retrospectively collected from medical files. An adequate desmopressin test response was defined based on a peak FVIII level of >= 30 IU/dl. Results A total of 248 patients with a median age of 38 years (interquartile range 25-49) were included. An adequate desmopressin test response was documented in 25% and 73% of patients with moderate and mild hemophilia, respectively. In adequate responders, 51% of bleeds were exclusively treated with FVIII concentrates, 24% exclusively with desmopressin, 21% with a combination of both and 4% with other treatments. In 54% of bleeds treated with a single dose of factor concentrates, the expected FVIII level after desmopressin exceeded the level targeted. Conclusion Most bleeds in patients with an adequate response to desmopressin are treated with factor concentrates. These findings may indicate a suboptimal use of desmopressin and that barriers to the use of desmopressin should be explored.Thrombosis and Hemostasi
Association study with Wegener granulomatosis of the human phospholipase Cγ2 gene
BACKGROUND: Wegener Granulomatosis (WG) is a multifactorial disease of yet unknown aetiology characterized by granulomata of the respiratory tract and systemic necrotizing vasculitis. Analyses of candidate genes revealed several associations, e.g. with α(1)-antitrypsin, proteinase 3 and with the HLA-DPB1 locus. A mutation in the abnormal limb mutant 5 (ALI5) mouse in the region coding for the hydrophobic ridge loop 3 (HRL3) of the phospholipaseCγ2 (PLCγ-2) gene, corresponding to human PLCγ-2 exon 27, leads to acute and chronic inflammation and granulomatosis. For that reason, we screened exons 11, 12 and 13 coding for the hydrophobic ridge loop 1 and 2 (HRL1 and 2, respectively) and exon 27 of the PLCγ-2 protein by single strand conformation polymorphism (SSCP), sequencing and PCR/ restriction fragment length polymorphism (RFLP) analyses. In addition, we screened indirectly for disease association via 4 microsatellites with pooled DNA in the PLCγ-2 gene. RESULTS: Although a few polymorphisms in these distinct exons were observed, significant differences in allele frequencies were not identified between WG patients and respective controls. In addition, the microsatellite analyses did not reveal a significant difference between our patient and control cohort. CONCLUSION: This report does not reveal any hints for an involvement of the PLCγ-2 gene in the pathogenesis of WG in our case-control study
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