Recommendations for the treatment of epilepsy in adult patients in general practice in Belgium: an update

In 2008, a group of Belgian epilepsy experts published recommendations for antiepileptic drug (AED) treatment of epilepsies in adults and children. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence for efficacy, common daily practice and the personal views and experiences of the authors. In November 2011 the validity of these recommendations was reviewed by the same group of Belgian epilepsy experts who contributed to the preparation of the original paper. The recommendations made in 2008 for initial monotherapy in paediatric patients were still considered to be valid, except for the first choice treatment for childhood absence epilepsy. This update therefore focuses on the treatment recommendations for initial monotherapy and add-on treatment in adult patients. Several other relevant aspects of treatment with AEDs are addressed, including considerations for optimal combination of AEDs (rational polytherapy), pharmacokinetic properties, pharmacodynamic and pharmacokinetic interaction profile, adverse effects, comorbidity, treatment of elderly patients, AED treatment during pregnancy, and generic substitution of AEDs

Investigation into the removal of an easy-care crosslinking agent from cotton and the subsequent regeneration of lyocell-type fibres

Dimethylol dihydroxyethylene urea (DMDHEU)-treated cotton fabrics were treated with alkali or alternatively acid followed by alkali for increasing time periods, and their effectiveness in removing the crosslinking agent was investigated by surface (X-ray photoelectron spectroscopy) analysis, bulk analysis, crease recovery angle performance and solubility in specific solvents. The cellulose yield after the chemical stripping processes was established and the effect of the acid and alkali treatments on the degree of polymerisation of the resultant cellulose determined. Surface and bulk analyses and solubility tests suggested that alkali alone could not remove the DMDHEU from the crease-resist-treated cotton fabric. However, a sequential acid/alkali treatment effectively removed the easy-care finish from the cotton fabric and produced a commercially viable yield of cellulose

Business model in IPO prospectuses: insights from Italian Innovation Companies

How do companies to be listed deal with the voluntary disclosure of their business model? Is it true that firms with greater intellectual capital resources and technological innovation endowments are less prone to full disclosure? This paper aims to examine the choices of voluntary disclosure of the business model made by three Italian manufacturing companies in initial public offering prospectuses. The objective is to explore whether any differences exist and may be related to the type of innovation underlying the firms’ business model. A series of interviews with the top management allows to deeply understand the business model of each company. A content analysis allows to measure the level of disclosure and identify the strategic concepts of the business model and their relevance. The study provides evidence that companies with a business model based on technology-push and design-driven innovation have a lower propensity to the full disclosure of their intangible resources, particularly of those based on knowledge as some could be also invisible. The paper contributes to the ongoing debate on the role of business and financial reporting

From noted ‘phenomenon’ to ‘missing person’: A case of the historical construction of the unter-journalist

Tim Hewat was celebrated during his tenure at Granada Television as one of the most influential journalists working in Britain in the second half of the 20th century, but then largely forgotten for 30 years.This is explained as a function of the specific historicization of journalists, reflecting both academic prejudices and occupational values. The history of journalism is largely devoid of the lived experiences of the majority of its practitioners. Hewat’s case indicates that journalists disappear from history when they step outside the domains of valorized media institutions and journalism hierarchies that contribute to notions such as the Fourth Estate. Mobilizing Paul Thompson’s category of ‘underclasses’, this article argues that this reductionism has largely rendered the majority of journalists historically invisible and classified them as unter-journalists , a kind of sub-category which does not comply with a priori norms. © The Author(s) 2010