8,763 research outputs found
Karen Rothenberg’s (Not So) Secret Roles and Contributions at the U.S. National Institutes of Health
Geometric Phase and Modulo Relations for Probability Amplitudes as Functions on Complex Parameter Spaces
We investigate general differential relations connecting the respective
behavior s of the phase and modulo of probability amplitudes of the form
\amp{\psi_f}{\psi}, where is a fixed state in Hilbert space
and is a section of a holomorphic line bundle over some complex
parameter space. Amplitude functions on such bundles, while not strictly
holomorphic, nevertheless satisfy generalized Cauchy-Riemann conditions
involving the U(1) Berry-Simon connection on the parameter space. These
conditions entail invertible relations between the gradients of the phase and
modulo, therefore allowing for the reconstruction of the phase from the modulo
(or vice-versa) and other conditions on the behavior of either polar component
of the amplitude. As a special case, we consider amplitude functions valued on
the space of pure states, the ray space , where
transition probabilities have a geometric interpretation in terms of geodesic
distances as measured with the Fubini-Study metric. In conjunction with the
generalized Cauchy-Riemann conditions, this geodesic interpretation leads to
additional relations, in particular a novel connection between the modulus of
the amplitude and the phase gradient, somewhat reminiscent of the WKB formula.
Finally, a connection with geometric phases is established.Comment: 11 pages, 1 figure, revtex
Decoding the Encoding of Functional Brain Networks: an fMRI Classification Comparison of Non-negative Matrix Factorization (NMF), Independent Component Analysis (ICA), and Sparse Coding Algorithms
Brain networks in fMRI are typically identified using spatial independent
component analysis (ICA), yet mathematical constraints such as sparse coding
and positivity both provide alternate biologically-plausible frameworks for
generating brain networks. Non-negative Matrix Factorization (NMF) would
suppress negative BOLD signal by enforcing positivity. Spatial sparse coding
algorithms ( Regularized Learning and K-SVD) would impose local
specialization and a discouragement of multitasking, where the total observed
activity in a single voxel originates from a restricted number of possible
brain networks.
The assumptions of independence, positivity, and sparsity to encode
task-related brain networks are compared; the resulting brain networks for
different constraints are used as basis functions to encode the observed
functional activity at a given time point. These encodings are decoded using
machine learning to compare both the algorithms and their assumptions, using
the time series weights to predict whether a subject is viewing a video,
listening to an audio cue, or at rest, in 304 fMRI scans from 51 subjects.
For classifying cognitive activity, the sparse coding algorithm of
Regularized Learning consistently outperformed 4 variations of ICA across
different numbers of networks and noise levels (p0.001). The NMF algorithms,
which suppressed negative BOLD signal, had the poorest accuracy. Within each
algorithm, encodings using sparser spatial networks (containing more
zero-valued voxels) had higher classification accuracy (p0.001). The success
of sparse coding algorithms may suggest that algorithms which enforce sparse
coding, discourage multitasking, and promote local specialization may capture
better the underlying source processes than those which allow inexhaustible
local processes such as ICA
Scalar Quantum Field Theory with Cubic Interaction
In this paper it is shown that an i phi^3 field theory is a physically
acceptable field theory model (the spectrum is positive and the theory is
unitary). The demonstration rests on the perturbative construction of a linear
operator C, which is needed to define the Hilbert space inner product. The C
operator is a new, time-independent observable in PT-symmetric quantum field
theory.Comment: Corrected expressions in equations (20) and (21
Biorthogonal quantum mechanics
The Hermiticity condition in quantum mechanics required for the characterization of (a) physical observables and (b) generators of unitary motions can be relaxed into a wider class of operators whose eigenvalues are real and whose eigenstates are complete. In this case, the orthogonality of eigenstates is replaced by the notion of biorthogonality that defines the relation between the Hilbert space of states and its dual space. The resulting quantum theory, which might appropriately be called 'biorthogonal quantum mechanics', is developed here in some detail in the case for which the Hilbert-space dimensionality is finite. Specifically, characterizations of probability assignment rules, observable properties, pure and mixed states, spin particles, measurements, combined systems and entanglements, perturbations, and dynamical aspects of the theory are developed. The paper concludes with a brief discussion on infinite-dimensional systems. © 2014 IOP Publishing Ltd
Acute reduction of microglia does not alter axonal injury in a mouse model of repetitive concussive traumatic brain injury
The pathological processes that lead to long-term consequences of multiple concussions are unclear. Primary mechanical damage to axons during concussion is likely to contribute to dysfunction. Secondary damage has been hypothesized to be induced or exacerbated by inflammation. The main inflammatory cells in the brain are microglia, a type of macrophage. This research sought to determine the contribution of microglia to axon degeneration after repetitive closed-skull traumatic brain injury (rcTBI) using CD11b-TK (thymidine kinase) mice, a valganciclovir-inducible model of macrophage depletion. Low-dose (1 mg/mL) valganciclovir was found to reduce the microglial population in the corpus callosum and external capsule by 35% after rcTBI in CD11b-TK mice. At both acute (7 days) and subacute (21 days) time points after rcTBI, reduction of the microglial population did not alter the extent of axon injury as visualized by silver staining. Further reduction of the microglial population by 56%, using an intermediate dose (10 mg/mL), also did not alter the extent of silver staining, amyloid precursor protein accumulation, neurofilament labeling, or axon injury evident by electron microscopy at 7 days postinjury. Longer treatment of CD11b-TK mice with intermediate dose and treatment for 14 days with high-dose (50 mg/mL) valganciclovir were both found to be toxic in this injury model. Altogether, these data are most consistent with the idea that microglia do not contribute to acute axon degeneration after multiple concussive injuries. The possibility of longer-term effects on axon structure or function cannot be ruled out. Nonetheless, alternative strategies directly targeting injury to axons may be a more beneficial approach to concussion treatment than targeting secondary processes of microglial-driven inflammation
The quantum brachistochrone problem for non-Hermitian Hamiltonians
Recently Bender, Brody, Jones and Meister found that in the quantum brachistochrone problem the passage time needed for the evolution of certain initial states into specified final states can be made arbitrarily small, when the time-evolution operator is taken to be non-Hermitian but PT-symmetric. Here we demonstrate that such phenomena can also be obtained for non-Hermitian Hamiltonians for which PT-symmetry is completely broken, i.e. dissipative systems. We observe that the effect of a tunable passage time can be achieved by projecting between orthogonal eigenstates by means of a time-evolution operator associated with a non-Hermitian Hamiltonian. It is not essential that this Hamiltonian is PT-symmetric
Universal relation between Green's functions in random matrix theory
We prove that in random matrix theory there exists a universal relation
between the one-point Green's function and the connected two- point Green's
function given by \vfill N^2 G_c(z,w) = {\part^2 \over \part z \part w}
\log (({G(z)- G(w) \over z -w}) + {\rm {irrelevant \ factorized \ terms.}}
This relation is universal in the sense that it does not depend on the
probability distribution of the random matrices for a broad class of
distributions, even though is known to depend on the probability
distribution in detail. The universality discussed here represents a different
statement than the universality we discovered a couple of years ago, which
states that is independent of the probability distribution,
where denotes the width of the spectrum and depends sensitively on the
probability distribution. It is shown that the universality proved here also
holds for the more general problem of a Hamiltonian consisting of the sum of a
deterministic term and a random term analyzed perturbatively by Br\'ezin,
Hikami, and Zee.Comment: 34 pages, macros appended (shorts, defs, boldchar), hard figures or
PICT figure files available from: [email protected]
On quantum microcanonical equilibrium
A quantum microcanonical postulate is proposed as a basis for the equilibrium properties of small quantum systems. Expressions for the corresponding density of states are derived, and are used to establish the existence of phase transitions for finite quantum systems. A grand microcanonical ensemble is introduced, which can be used to obtain new rigorous results in quantum statistical mechanics.Accepted versio
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