Note on exponential families of distributions

We show that an arbitrary probability distribution can be represented in exponential form. In physical contexts, this implies that the equilibrium distribution of any classical or quantum dynamical system is expressible in grand canonical form.Comment: 5 page

Two-body scattering in a trap and a special periodic phenomenon sensitive to the interaction

Two-body scattering of neutral particles in a trap is studied theoretically. The control of the initial state is realized by using optical traps. The collisions inside the trap occur repeatedly; thereby the effect of interaction can be accumulated. Two periodic phenomena with a shorter and a much longer period, respectively, are found. The latter is sensitive to the interaction. Instead of measuring the differential cross section as usually does, the measurement of the longer period and the details of the periodic behavior might be a valid source of information on weak interactions among neutral particles.Comment: 5 pages, 5 figure

Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities

Alzheimer\u27s disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury (TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in ∼30% of human subjects after severe TBI. Intra-axonal accumulations of tau but not tangle-like pathologies have also been found in these patients. Whether and how these acute accumulations contribute to subsequent AD development is not known, and the interaction between Aβ and tau in the setting of TBI has not been investigated. Here, we report that controlled cortical impact TBI in 3xTg-AD mice resulted in intra-axonal Aβ accumulations and increased phospho-tau immunoreactivity at 24 h and up to 7 d after TBI. Given these findings, we investigated the relationship between Aβ and tau pathologies after trauma in this model by systemic treatment of Compound E to inhibit γ-secretase activity, a proteolytic process required for Aβ production. Compound E treatment successfully blocked posttraumatic Aβ accumulation in these injured mice at both time points. However, tau pathology was not affected. Our data support a causal role for TBI in acceleration of AD-related pathologies and suggest that TBI may independently affect Aβ and tau abnormalities. Future studies will be required to assess the behavioral and long-term neurodegenerative consequences of these pathologies

Random Hamiltonian in thermal equilibrium

A framework for the investigation of disordered quantum systems in thermal equilibrium is proposed. The approach is based on a dynamical model--which consists of a combination of a double-bracket gradient flow and a uniform Brownian fluctuation--that `equilibrates' the Hamiltonian into a canonical distribution. The resulting equilibrium state is used to calculate quenched and annealed averages of quantum observables.Comment: 8 pages, 4 figures. To appear in DICE 2008 conference proceeding

On observability of Renyi's entropy

Despite recent claims we argue that Renyi's entropy is an observable quantity. It is shown that, contrary to popular belief, the reported domain of instability for Renyi entropies has zero measure (Bhattacharyya measure). In addition, we show the instabilities can be easily emended by introducing a coarse graining into an actual measurement. We also clear up doubts regarding the observability of Renyi's entropy in (multi--)fractal systems and in systems with absolutely continuous PDF's.Comment: 18 pages, 1 EPS figure, REVTeX, minor changes, accepted to Phys. Rev.

Metric approach to quantum constraints

A new framework for deriving equations of motion for constrained quantum systems is introduced, and a procedure for its implementation is outlined. In special cases the framework reduces to a quantum analogue of the Dirac theory of constrains in classical mechanics. Explicit examples involving spin-1/2 particles are worked out in detail: in one example our approach coincides with a quantum version of the Dirac formalism, while the other example illustrates how a situation that cannot be treated by Dirac's approach can nevertheless be dealt with in the present scheme.Comment: 13 pages, 1 figur

Spectral Properties of the k-Body Embedded Gaussian Ensembles of Random Matrices for Bosons

We consider $m$ spinless Bosons distributed over $l$ degenerate single-particle states and interacting through a $k$-body random interaction with Gaussian probability distribution (the Bosonic embedded $k$-body ensembles). We address the cases of orthogonal and unitary symmetry in the limit of infinite matrix dimension, attained either as $l \to \infty$ or as $m \to \infty$. We derive an eigenvalue expansion for the second moment of the many-body matrix elements of these ensembles. Using properties of this expansion, the supersymmetry technique, and the binary correlation method, we show that in the limit $l \to \infty$ the ensembles have nearly the same spectral properties as the corresponding Fermionic embedded ensembles. Novel features specific for Bosons arise in the dense limit defined as $m \to \infty$ with both $k$ and $l$ fixed. Here we show that the ensemble is not ergodic, and that the spectral fluctuations are not of Wigner-Dyson type. We present numerical results for the dense limit using both ensemble unfolding and spectral unfolding. These differ strongly, demonstrating the lack of ergodicity of the ensemble. Spectral unfolding shows a strong tendency towards picket-fence type spectra. Certain eigenfunctions of individual realizations of the ensemble display Fock-space localization.Comment: Minor corrections; figure 5 slightly modified (30 pages, 6 figs

Spectral Properties of the k-Body Embedded Gaussian Ensembles of Random Matrices

We consider $m$ spinless Fermions in $l > m$ degenerate single-particle levels interacting via a $k$-body random interaction with Gaussian probability distribution and $k <= m$ in the limit $l$ to infinity (the embedded $k$-body random ensembles). We address the cases of orthogonal and unitary symmetry. We derive a novel eigenvalue expansion for the second moment of the Hilbert-space matrix elements of these ensembles. Using properties of the expansion and the supersymmetry technique, we show that for $2k > m$, the average spectrum has the shape of a semicircle, and the spectral fluctuations are of Wigner-Dyson type. Using a generalization of the binary correlation approximation, we show that for $k << m << l$, the spectral fluctuations are Poissonian. This is consistent with the case $k = 1$ which can be solved explicitly. We construct limiting ensembles which are either fully integrable or fully chaotic and show that the $k$-body random ensembles lie between these two extremes. Combining all these results we find that the spectral correlations for the embedded ensembles gradually change from Wigner-Dyson for $2k > m$ to Poissonian for $k << m << l$.Comment: 44 pages, 3 postscript figures, revised version including a new proof of one of our main claim

Nuclear Structure Calculations with Low-Momentum Potentials in a Model Space Truncation Approach

We have calculated the ground-state energy of the doubly magic nuclei 4He, 16O and 40Ca within the framework of the Goldstone expansion starting from various modern nucleon-nucleon potentials. The short-range repulsion of these potentials has been renormalized by constructing a low-momentum potential V-low-k. We have studied the connection between the cutoff momemtum Lambda and the size of the harmonic oscillator space employed in the calculations. We have found a fast convergence of the results with a limited number of oscillator quanta.Comment: 6 pages, 8 figures, to be published on Physical Review

Minimal long-term neurobehavioral impairments after endovascular perforation subarachnoid hemorrhage in mice

AbstractCognitive deficits are among the most severe and pervasive consequences of aneurysmal subarachnoid hemorrhage (SAH). A critical step in developing therapies targeting such outcomes is the characterization of experimentally-tractable pre-clinical models that exhibit multi-domain neurobehavioral deficits similar to those afflicting humans. We therefore searched for neurobehavioral abnormalities following endovascular perforation induction of SAH in mice, a heavily-utilized model. We instituted a functional screen to manage variability in injury severity, then assessed acute functional deficits, as well as activity, anxiety-related behavior, learning and memory, socialization, and depressive-like behavior at sub-acute and chronic time points (up to 1 month post-injury). Animals in which SAH was induced exhibited reduced acute functional capacity and reduced general activity to 1 month post-injury. Tests of anxiety-related behavior including central area time in the elevated plus maze and thigmotaxis in the open field test revealed increased anxiety-like behavior at subacute and chronic time-points, respectively. Effect sizes for subacute and chronic neurobehavioral endpoints in other domains, however, were small. In combination with persistent variability, this led to non-significant effects of injury on all remaining neurobehavioral outcomes. These results suggest that, with the exception of anxiety-related behavior, alternate mouse models are required to effectively analyze cognitive outcomes after SAH.</jats:p