395 research outputs found
Meson Transition Form Factors From A QCD Model Field Theory
We discuss form factors and coupling constants for the , and interactions generated by a model
field theory that produces finite size meson modes. The approach
implements dressing of the vertices and propagators consistent with dynamical
chiral symmetry breaking, gauge invariance, quark confinement and perturbative
QCD.Comment: 10 pages incl 4 figs in a single gzip-ed, uuencoded Postscript file;
Paper presented at {\it The International School of Nuclear Physics: Quarks
in Hadrons and Nuclei}, Erice, September 1995; Proceedings to appear in Prog.
Part. Nucl. Phys. {\bf 36
A Pionic Hadron Explains the Muon Magnetic Moment Anomaly
A significant discrepancy exists between experiment and calculations of the
muon's magnetic moment. We find that standard formulas for the hadronic vacuum
polarization term have overlooked pionic states known to exist. Coulomb binding
alone guarantees states that quantum mechanically mix with the
meson. A simple 2-state mixing model explains the magnetic moment
discrepancy for a mixing angle of order . The relevant
physical state is predicted to give a tiny observable bump in the ratio R(s) of
annihilation at a low energy not previously searched. The burden of
proof is reversed for claims that conventional physics cannot explain the
muon's anomalous moment.Comment: 14 pages, 2 figures, revised version, accepted for publication in
Physics Letters
Engineering novel complement activity into a pulmonary surfactant protein
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance. In the classical and lectin activation pathways, it is initiated when complexes composed of separate recognition and activation subcomponents bind to a pathogen surface. Despite its apparent complexity, recognition-mediated activation has evolved independently in three separate protein families, C1q, mannose-binding lectins (MBLs), and serum ficolins. Although unrelated, all have bouquet-like architectures and associate with complement-specific serine proteases: MBLs and ficolins with MBL-associated serine protease-2 (MASP-2) and C1q with C1r and C1s. To examine the structural requirements for complement activation, we have created a number of novel recombinant rat MBLs in which the position and orientation of the MASP-binding sites have been changed. We have also engineered MASP binding into a pulmonary surfactant protein (SP-A), which has the same domain structure and architecture as MBL but lacks any intrinsic complement activity. The data reveal that complement activity is remarkably tolerant to changes in the size and orientation of the collagenous stalks of MBL, implying considerable rotational and conformational flexibility in unbound MBL. Furthermore, novel complement activity is introduced concurrently with MASP binding in SP-A but is uncontrolled and occurs even in the absence of a carbohydrate target. Thus, the active rather than the zymogen state is default in lectin·MASP complexes and must be inhibited through additional regions in circulating MBLs until triggered by pathogen recognition
Off-Shell Axial Anomaly via the \gamma^* \pi^0 -> \gamma Transition
The form factor, including the extension
off the pion mass-shell, is obtained from a generalized impulse approximation
within a QCD-based model field theory known to provide an excellent description
of the pion charge form factor. This approach implements dressing of the vertex
functions and propagators consistent with dynamical chiral symmetry breaking,
gauge invariance, quark confinement and perturbative QCD. Soft nonperturbative
behavior, dictated by the axial anomaly, is found to evolve to the perturbative
QCD limit only for \mbox{}.Comment: 10 Pages, 3 figures (uuencoded and appended), REVTE
Poincare Invariant Algebra From Instant to Light-Front Quantization
We present the Poincare algebra interpolating between instant and light-front
time quantizations. The angular momentum operators satisfying SU(2) algebra are
constructed in an arbitrary interpolation angle and shown to be identical to
the ordinary angular momentum and Leutwyler-Stern angular momentum in the
instant and light-front quantization limits, respectively. The exchange of the
dynamical role between the transverse angular mometum and the boost operators
is manifest in our newly constructed algebra.Comment: 21 pages, 3 figures, 1 tabl
Broadening of Plasmonic Resonance Due to Electron Collisions with Nanoparticle Boundary: а Quantum Mechanical Consideration
We present a quantum mechanical approach to calculate broadening of plasmonic
resonances in metallic nanostructures due to collisions of electrons with the
surface of the structure. The approach is applicable if the characteristic size
of the structure is much larger than the de Broglie electron wavelength in the
metal. The approach can be used in studies of plasmonic properties of both
single nanoparticles and arrays of nanoparticles.Comment: 9 page
Tri-meson-mixing of -- and -- in the light-cone quark model
The radiative transition form factors of the pseudoscalar mesons {,
, } and the vector mesons {, , } are restudied
with -- and -- in tri-meson-mixing
pattern, which is described by tri-mixing matrices in the light-cone
constituent quark model. The experimental transition decay widths are better
reproduced with tri-meson-mixing than previous results in a two-mixing-angle
scenario of only two-meson - mixing and - mixing.Comment: 8 pages, 6 figures, final version to appear in EPJ
Presenting features and long-term effects of growth hormone treatment of children with optic nerve hypoplasia/septo-optic dysplasia
<p>Abstract</p> <p>Background</p> <p>Optic nerve hypoplasia (ONH) with/or without septo-optic dysplasia (SOD) is a known concomitant of congenital growth hormone deficiency (CGHD).</p> <p>Methods</p> <p>Demographic and longitudinal data from KIGS, the Pfizer International Growth Database, were compared between 395 subjects with ONH/SOD and CGHD and 158 controls with CGHD without midline pathology.</p> <p>Results</p> <p>ONH/SOD subjects had higher birth length/weight, and mid-parental height SDS. At GH start, height, weight, and BMI SDS were higher in the ONH/SOD group. After 1 year of GH, both groups showed similar changes in height SDS, while weight and BMI SDS remained higher in the ONH/SOD group. The initial height responses of the two groups were similar to those predicted using the KIGS-derived prediction model for children with idiopathic GHD. At near-adult height, ONH/SOD and controls had similar height, weight, and BMI SDS.</p> <p>Conclusions</p> <p>Compared to children with CGHD without midline defects, those with ONH/SOD presented with greater height, weight, and BMI SDS. These differences persisted at 1 year of GH therapy, but appeared to be overcome by long-term GH treatment.</p
Measurements of Deuteron Photodisintegration up to 4.0 GeV
The first measurements of the differential cross section for the d(gamma,p)n
reaction up to 4.0 GeV were performed at Continuous Electron Beam Accelerator
Facility (CEBAF) at Jefferson Lab. We report the cross sections at the proton
center-of-mass angles of 36, 52, 69 and 89 degrees. These results are in
reasonable agreement with previous measurements at lower energy. The 89 and 69
degree data show constituent-counting-rule behavior up to 4.0 GeV photon
energy. The 36 and 52 degree data disagree with the counting rule behavior. The
quantum chromodynamics (QCD) model of nuclear reactions involving reduced
amplitudes disagrees with the present data.Comment: 5 pages (REVTeX), 1 figure (postscript
Biogenesis of the Signal Recognition Particle (Srp) Involves Import of Srp Proteins into the Nucleolus, Assembly with the Srp-Rna, and Xpo1p-Mediated Export
The signal recognition particle (SRP) targets nascent secretory proteins to the ER, but how and where the SRP assembles is largely unknown. Here we analyze the biogenesis of yeast SRP, which consists of an RNA molecule (scR1) and six proteins, by localizing all its components. Although scR1 is cytoplasmic in wild-type cells, nuclear localization was observed in cells lacking any one of the four SRP “core proteins” Srp14p, Srp21p, Srp68p, or Srp72p. Consistently, a major nucleolar pool was detected for these proteins. Sec65p, on the other hand, was found in both the nucleoplasm and the nucleolus, whereas Srp54p was predominantly cytoplasmic. Import of the core proteins into the nucleolus requires the ribosomal protein import receptors Pse1p and Kap123p/Yrb4p, which might, thus, constitute a nucleolar import pathway. Nuclear export of scR1 is mediated by the nuclear export signal receptor Xpo1p, is distinct from mRNA transport, and requires, as evidenced by the nucleolar accumulation of scR1 in a dis3/rrp44 exosome component mutant, an intact scR1 3′ end. A subset of nucleoporins, including Nsp1p and Nup159p (Rat7p), are also necessary for efficient translocation of scR1 from the nucleus to the cytoplasm. We propose that assembly of the SRP requires import of all SRP core proteins into the nucleolus, where they assemble into a pre-SRP with scR1. This particle can then be targeted to the nuclear pores and is subsequently exported to the cytoplasm in an Xpo1p-dependent way
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