Effect of closing facilities on electroconvulsive therapy use in Glasgow

<p>Objectives: To assess the effect of closure of electroconvulsive therapy (ECT) centers on ECT use. Electroconvulsive therapy remains a recommended and effective treatment for mental disorders. Declining rates of ECT use in the United Kingdom have been observed over the last 20 years with anecdotal observations that use has declined as the result of centralization of provision. In Glasgow, there have been site closures in the north with no such rationing taking place in the south.</p> <p>Methods: A naturalistic retrospective survey of the number of ECT courses commenced each year in Glasgow, with a comparison made between the north and the south of the city. Data were available from 1996 to 2008.</p> <p>Results: Our analysis showed no change in the mean number of ECT courses commenced in southern AQ2 Glasgow (period 1, 42.25; period 2, 41.83; period 3, 31; F = 1.369; P = 0.298). There was a significant reduction in the mean number of ECT treatments commenced in northern Glasgow (period 1, 91.25; period 2, 51; period 3, 33.33; F = 10.06; P = 0.04).</p> <p>Conclusions: In northern Glasgow, where there have been 2 site closures since 1996, ECT use has declined. This trend was not replicated in the south of the city. This would suggest that the closure of ECT centers does reduce the use of ECT. However, there may be a number of confounding variables that could not be factored into the analysis because of lack of available data.</p&gt

Sparse and stable Markowitz portfolios

We consider the problem of portfolio selection within the classical Markowitz mean-variance framework, reformulated as a constrained least-squares regression problem. We propose to add to the objective function a penalty proportional to the sum of the absolute values of the portfolio weights. This penalty regularizes (stabilizes) the optimization problem, encourages sparse portfolios (i.e. portfolios with only few active positions), and allows to account for transaction costs. Our approach recovers as special cases the no-short-positions portfolios, but does allow for short positions in limited number. We implement this methodology on two benchmark data sets constructed by Fama and French. Using only a modest amount of training data, we construct portfolios whose out-of-sample performance, as measured by Sharpe ratio, is consistently and significantly better than that of the naive evenly-weighted portfolio which constitutes, as shown in recent literature, a very tough benchmark.Comment: Better emphasis of main result, new abstract, new examples and figures. New appendix with full details of algorithm. 17 pages, 6 figure

On ‘Organized Crime’ in the illicit antiquities trade: moving beyond the definitional debate

The extent to which ‘organized crime’ is involved in illicit antiquities trafficking is unknown and frequently debated. This paper explores the significance and scale of the illicit antiquities trade as a unique transnational criminal phenomenon that is often said to be perpetrated by and exhibit traits of so-called ‘organized crime.’ The definitional debate behind the term ‘organized crime’ is considered as a potential problem impeding our understanding of its existence or extent in illicit antiquities trafficking, and a basic progression-based model is then suggested as a new tool to move beyond the definitional debate for future research that may help to elucidate the actors, processes and criminal dynamics taking place within the illicit antiquities trade from source to market. The paper concludes that researchers should focus not on the question of whether organized criminals- particularly in a traditionally conceived, mafia-type stereotypical sense- are involved in the illicit antiquities trade, but instead on the structure and progression of antiquities trafficking itself that embody both organized and criminal dynamics

New directions for service research: refreshing the process of theorizing to increase contribution

Purpose – For service research to develop as an applied social science there is the need to refresh the process of theorizing so it focuses not only on increasing new academic knowledge but also on knowledge that is managerially relevant. Guidelines are provided to achieve this.Design/methodology/approach – A theorizing process that integrates general theoretic perspectives and contextual research to develop midrange theory is developed. The process is based on the philosophical foundations of pragmatism and abductive reasoning, which has their origins in the 1950s when the management sciences were being established.Findings –A recent research stream that develops midrange theory about customer and actor engagement is used to illustrate the theorizing process.Practical Implications – Practicing managers, customers and other stakeholders in a service system use theory, so there is a need to focus on how theory is used in specific service contexts and how this research leads to academic knowledge that is managerially relevant. Thus, as applied social science, service research needs to explicitly focus on bridging the theory-praxis gap with midrange theory byincorporating a general theoretic perspective and contextual research.Originality/value - The contribution comes from providing a broader framework to guide the theorizing process that integrates general theoretic perspectives and applied research to develop midrange theory. While general theories operate at the most abstract level of conceptualization midrange theories are context-specific, and applied theory (theories-in-use) embedded in empirical researc

Unrecognized pollutant risks to the Great Barrier Reef

This report summarises the occurrence, distribution, risks and toxicity of ten pollutants to the marine environment: marine debris, microplastics, sewage-sourced contaminants, trace metals, anti-foulants, coal dust, petroleum hydrocarbon contaminants, flame retardants, polychlorinated biphenyls (PCBs) and non-photosystem II (PSII) pesticides

Globular Clusters in the dE,N galaxy NGC 3115 DW1: New Insights from Spectroscopy and HST Photometry

The properties of globular clusters in dwarf galaxies are key to understanding the formation of globular cluster systems, and in particular in verifying scenarios in which globular cluster systems of larger galaxies formed (at least partly) from the accretion of dwarf galaxies. Here, we revisit the globular cluster system of the dE,N galaxy NGC 3115 DW1 - a companion of the nearby S0 galaxy NGC 3115 - adding Keck/LRIS spectroscopy and HST/WFPC2 imaging to previous ground-based photometry. Spectra for seven globular clusters reveal normal abundance ratios with respect to the Milky Way and M31 clusters, as well as a relatively high mean metallicity ([Fe/H] = -1.0+/-0.1 dex). Crude kinematics indicate a high velocity dispersion within 10 kpc which could either be caused by dark matter dominated outer regions, or by the stripping of outer globular clusters by the nearby giant galaxy NGC 3115. The total galaxy mass out to 3 and 10 kpc lies between 10^10 and 10^11 solar masses and 2*10^10 and 4*10^11 solar masses, respectively, depending on the mass estimator used and the assumptions on cluster orbits and systemic velocity. The HST imaging allows measurement of sizes for two clusters, returning core radii around 2.0 pc, similar to the sizes observed in other galaxies. Spectroscopy allows an estimate of the degree of contamination by foreground stars or background galaxies for the previous ground-based photometry, but does not require a revision of previous results: NGC 3115 DW1 hosts around 60+/-20 clusters which corresponds to a specific frequency of 4.9+/-1.9, on the high end for massive dEs. Given its absolute magnitude (M_V=-17.7 mag) and the properties of its cluster system, NGC 3115 DW1 appears to be a transition between a luminous dE and low-luminosity E galaxy.Comment: 25 pages, 8 figures, accepted for publication in The Astronomical Journal, August 2000 issu