A Diffractive Study of Parametric Process in Nonlinear Photonic Crystals

We report a general description of quasi-phase-matched parametric process in nonlinear photonic crystals (NLPC) by extending the conventional X-ray diffraction theory in solids. Under the virtual wave approximation, phase-matching resonance is equivalent to the diffraction of the scattered virtual wave. Hence a modified NLPC Ewald construction can be built up, which illustrates the nature of the accident for the diffraction of the virtual wave in NLPC and further reveals the complete set of diffractions of the virtual wave for both of the air-dielectric and dielectric-dielectric contacts. We show the two basic linear sequences, the anti-stacking and para-stacking linear sequences, in one-dimension (1D) NLPC and present a general rule for multiple phase-matching resonances in 1D NLPC. The parameters affecting the NLPC structure factor are investigated, which indicate that not only the Ewald construction but also the relative NLPC atom size together determine whether a diffraction of the virtual wave can occur in 2D NLPC. The results also show that 1D NLPC is a better choice than 2D NLPC for a single parametric process

Magnetic Field Amplification in Galaxy Clusters and its Simulation

We review the present theoretical and numerical understanding of magnetic field amplification in cosmic large-scale structure, on length scales of galaxy clusters and beyond. Structure formation drives compression and turbulence, which amplify tiny magnetic seed fields to the microGauss values that are observed in the intracluster medium. This process is intimately connected to the properties of turbulence and the microphysics of the intra-cluster medium. Additional roles are played by merger induced shocks that sweep through the intra-cluster medium and motions induced by sloshing cool cores. The accurate simulation of magnetic field amplification in clusters still poses a serious challenge for simulations of cosmological structure formation. We review the current literature on cosmological simulations that include magnetic fields and outline theoretical as well as numerical challenges.Comment: 60 pages, 19 Figure

Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

Several susceptibility loci for classical Hodgkin lymphoma (cHL) have been reported, however much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies (GWAS), a new GWAS, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all cHL at 6q22.33 (rs9482849, P=1.52 × 10-8) and for nodular sclerosis HL (NSHL) at 3q28 (rs4459895, P=9.43 × 10-17), 6q23.3 (rs6928977, P=4.62 × 10-55 11), 10p14 (rs3781093, P=9.49 × 10-13), 13q34 (rs112998813, P=4.58 × 10-8) and 16p13.13 (rs34972832, P=2.12 × 10-8). Additionally, independent loci within the HLA region are observed for NSHL (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity HL (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.In the United Kingdom, Bloodwise (LLR; 10021) provided principal funding for the study. Support from Cancer Research UK (C1298/A8362 supported by the Bobby Moore Fund) and the Lymphoma Research Trust is also acknowledged. A.S. is supported by a clinical fellowship from Cancer Research UK. For the UK-GWAS, sample and data acquisition were supported by Breast Cancer Now, the European Union and the Lymphoma Research Trust. The UK-GWAS made use of control genotyping data generated by the WTCCC. For further information, please visit the publishr's website

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Clustering of Observed Diurnal Cycles of Precipitation over the United States for Evaluation of a WRF Multiphysics Regional Climate Ensemble

The diurnal cycle of precipitation during the summer season over the contiguous United States is examined in eight distinct regions. These were identified using cluster analysis applied to the diurnal cycle characteristics at 2141 rainfall gauges over the 10-yr period 1991–2000. Application of the clustering technique provides a physically meaningful way of identifying regions for comparison of model results with observations. The diurnal cycle for each region is specified in terms of 1) total precipitation, 2) frequency of precipitation occurrence, and 3) intensity of precipitation per occurrence on an hourly basis averaged over the 10-yr period. The amplitude and phase of each element of the diurnal cycle was obtained from harmonic analysis and has been compared with the results of a 24-member multiphysics ensemble of simulations produced by the Weather Research and Forecast (WRF) Model on a region-by-region basis. Three cumulus schemes, two radiation schemes, two microphysics schemes, and two planetary boundary layer schemes were included in the ensemble. Simulations of total precipitation showed reasonable agreement with observations in regions where the diurnal cycle is directly influenced by solar radiation, (e.g., the U.S. Southeast), but they were less successful in regions where other factors influence the diurnal cycle (e.g., the central United States). The diurnal cycle of precipitation frequency and intensity showed substantial biases in the simulations of all eight regions, namely, overestimation of occurrences and underestimation of intensities. Simulations were sensitive to the cumulus and radiation schemes but were largely insensitive to either microphysics or planetary boundary layer schemes