1,294 research outputs found
An analysis of the stopped-flow kinetics of gaseous ligand uptake and release by adult mouse erythrocytes
The Upper Limit for CH4 in the Protostellar Disk toward HL Tauri
We used high-resolution infrared spectra of the heavily embedded T Tauri star HL Tau to search for evidence of absorption due to the R0, R1, and R2 gas-phase CH4 ν3 lines near 3.3 μm. From this, we report a 3 σ upper limit of 1.3 × 1015 cm-2 for the CH4 gas column density toward HL Tau. Our results are compared to those found for CO gas toward this source and to the recent model for chemistry in the inner (10 AU) disks around T Tauri stars by Markwick et al. We find that the upper limit of methane ice+gas column density toward HL Tau, when compared to CO, is somewhat lower than but consistent with that measured toward other interstellar sources (~1%) but that it is much lower than that predicted in the Markwick et al. model and much less than the CH4/CO ratio (10%-80%) found in cometary volatiles. This has important implications for the processing of interstellar material and its incorporation into planetary bodies
An analysis of the reaction kinetics of the hexahaem nitrite reductase of the anaerobic rumen bacterium Wolinella succinogenes
The purification and some equilibrium properties of the nitrite reductase of the bacterium Wolinella succinogenes
Panchromatic Imaging of a Transitional Disk: The Disk of GM Aur in Optical and FUV Scattered Light
We have imaged GM Aur with HST, detected its disk in scattered light at 1400A
and 1650A, and compared these with observations at 3300A, 5550A, 1.1 microns,
and 1.6 microns. The scattered light increases at shorter wavelengths. The
radial surface brightness profile at 3300A shows no evidence of the 24AU radius
cavity that has been previously observed in sub-mm observations. Comparison
with dust grain opacity models indicates the surface of the entire disk is
populated with sub-micron grains. We have compiled an SED from 0.1 microns to 1
mm, and used it to constrain a model of the star+disk system that includes the
sub-mm cavity using the Monte Carlo Radiative Transfer code by Barbara Whitney.
The best-fit model image indicates that the cavity should be detectable in the
F330W bandpass if the cavity has been cleared of both large and small dust
grains, but we do not detect it. The lack of an observed cavity can be
explained by the presence of sub-microns grains interior to the sub-mm cavity
wall. We suggest one explanation for this which could be due to a planet of
mass <9 Jupiter masses interior to 24 AU. A unique cylindrical structure is
detected in the FUV data from the Advanced Camera for Surveys/Solar Blind
Channel. It is aligned along the system semi-minor axis, but does not resemble
an accretion-driven jet. The structure is limb-brightened and extends 190 +/-
35 AU above the disk midplane. The inner radius of the limb-brightening is 40
+/- 10 AU, just beyond the sub-millimeter cavity wall.Comment: 40 pages, 11 figures, 4 tables, accepted to Ap
Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections.
Despite significant research efforts aimed at understanding the neurobiological underpinnings of psychiatric disorders, the diagnosis and the evaluation of treatment of these disorders are still based solely on relatively subjective assessment of symptoms. Therefore, biological markers which could improve the current classification of psychiatry disorders, and in perspective stratify patients on a biological basis into more homogeneous clinically distinct subgroups, are highly needed. In order to identify novel candidate biological markers for major depression and schizophrenia, we have applied a focused proteomic approach using plasma samples from a large case-control collection. Patients were diagnosed according to DSM criteria using structured interviews and a number of additional clinical variables and demographic information were assessed. Plasma samples from 245 depressed patients, 229 schizophrenic patients and 254 controls were submitted to multi analyte profiling allowing the evaluation of up to 79 proteins, including a series of cytokines, chemokines and neurotrophins previously suggested to be involved in the pathophysiology of depression and schizophrenia. Univariate data analysis showed more significant p-values than would be expected by chance and highlighted several proteins belonging to pathways or mechanisms previously suspected to be involved in the pathophysiology of major depression or schizophrenia, such as insulin and MMP-9 for depression, and BDNF, EGF and a number of chemokines for schizophrenia. Multivariate analysis was carried out to improve the differentiation of cases from controls and identify the most informative panel of markers. The results illustrate the potential of plasma biomarker profiling for psychiatric disorders, when conducted in large collections. The study highlighted a set of analytes as candidate biomarker signatures for depression and schizophrenia, warranting further investigation in independent collections
A kinetic and equilibrium study of ligand binding to the monomeric and dimeric haem-containing globins of two chitons
- …