Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration

Aa robust inflammatory response to tissue damage and infection is conserved across almost all animal phyla. Neutrophils and macrophages, or their equivalents, are drawn to the wound site where they engulf cell and matrix debris and release signals that direct components of the repair process. This orchestrated cell migration is clinically important, and yet, to date, leukocyte chemotaxis has largely been studied in vitro. Here, we describe a genetically tractable in vivo wound model of inflammation in the Drosophila melanogaster embryo that is amenable to cinemicroscopy. For the first time, we are able to examine the roles of Rho-family small GTPases during inflammation in vivo and show that Rac-mediated lamellae are essential for hemocyte motility and Rho signaling is necessary for cells to retract from sites of matrix– and cell–cell contacts. Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues

Ornamental plants: annual reports and research summaries

The Ohio State University Extension Nursery, Landscape, and Turf Team (ENLTT) -- Extension Nursery, Landscape, and Turf Team (ENLTT) directory -- An evaluation of composts for landscape soil amendments / Mary Ann Rose and Hao Wang -- Aesthetic evaluation of crabapples at Secrest Arboretum in Wooster, Ohio: 1994-1995 / James A. Chatfield, Erik A. Draper, Kenneth C. Cochran, Peter W. Bristol and Charles E. Tubesing -- Evaluation of crabapples for apple scab at Secrest Arboretum in Wooster, Ohio: 1995 / Erik A. Draper, James A. Chatfield, Kenneth C. Cochran, Peter W. Bristol and Charles E. Tubesing -- Emergence, longevity, and aesthetic evaluations of flowers in ornamental crabapples at Secrest Arboretum in Wooster, Ohio: 1995 / Erik A. Draper, James A. Chatfield and Kenneth C. Cochran -- Environmental and cultural ornamental plant problems in Ohio: 1995 / Pamela J. Bennett and Jane A. Martin -- 1995 -A Challenging Year for Ohio golf courses / Joseph W. Rimelspach, John R. Street, Karl Danneberger, William E. Pound, Barbara Bloetscher -- Plant insect pest problems in Ohio: 1995 / Joseph F. Boggs, David J. Shetlar, Gary Yu Gao, Daniel Balser, Douglas C. Caldwell, Randall H. Zondag and James A. Chatfield -- Gypsy moth in Ohio: 1995 / Allan Baumgard, David F. James and Randall H. Zondag -- Landscape ornamental disease problems in Ohio: 1995 / James A. Chatfield, Nancy Taylor, Randall H. Zondag, Mary Ann Rose, Gary Yu Gao, Daniel R. Balser and David J. Shetlar -- The Response of native and naturalized trees to construction activity / T. Davis Sydnor, Joseph F. Boggs and Mary Ann Ros

An ideal journey: Making bus travel desirable

© 2016 Informa UK Limited, trading as Taylor & Francis Group. This paper explores the ways in which people use their travel-time on local buses, and explains how this knowledge can assist with efforts in many ‘auto-centric’ societies to make bus travel more attractive and encourage a shift away from excessive private car use. Framing the discussion around the concept of an ‘ideal bus journey’, this paper examines whether travel-time activities on-board the bus give subjective value to the journey experience. Particular attention is given to emergent mobile Information and Communications Technologies, which are rapidly reconfiguring the ways in which we can inhabit and use mobile spaces such as the bus. This paper reports a novel mixed-methodology, creating a synthesised analysis of online discussions, focus groups, and a large-scale questionnaire survey of 840 bus users in Bristol, UK. The findings demonstrate that the bus is a very active space, with high levels of travel-time activity. The most popular activities on the bus are those related to relaxation and personal benefit, such as reading, listening to music, and browsing the internet. It is the passengers themselves that are largely in control of their in-vehicle experience, being able to craft a range of different positive journey experiences through travel-time activity. However, negative experiences are very common, and there is a need to challenge unfavourable public perception and media representations of bus travel to create a more positive cultural construction of the bus which would allow for the concept of an ‘ideal journey’ to be more easily realised. Passengers are the main creators of their travel-time experience, however there is much that can be done by bus operators to facilitate different types of activity and encourage a desirable public space. The overarching message is that there is a distinct opportunity to unlock travel-time activity as a ‘Unique Selling Point’ of the bus. Creating a perception of the bus journey as a desirable piece of time will allow local bus services to compete with the car on their own terms, and assist with international efforts to encourage people out of their cars and onto public transport for some trips

Ornamental plants: annual reports and research reviews

Ohio State University Extension Nursery, Landscape, and Turf Team Directory: 1998 / Jack Kerrigan -- Floriculture Industry Roundtable of Ohio: 1998 / Charles Behnke -- Ohio State University Extension Buckeye Yard and Garden Line / James A. Chatfield, Pamela J. Bennett, Joseph F. Boggs, Gary Y. Gao, Jane C. Martin, David J. Shetlar and Randall H. Zondag -- Environmental and cultural problems of ornamental plants in Ohio: 1997 / Pamela J. Bennett and Jane C. Martin -- Insect and mite activity noted in Ohio nurseries and landscapes: 1997 / Joseph F. Boggs, David J. Shetlar, Jane C. Martin, Pamela J. Bennett, James A. Chatfield, Gary Y. Gao and Chris Carlson -- Summary of ornamental diseases in Ohio: 1997 / James A. Chatfield, Nancy J. Taylor, Stephen N. Nameth, Chris Carlson, Joseph F. Boggs, Jane C. Martin, Dan Balser and David Madison -- Weed problems in Ohio landscapes and nurseries: 1997 / Gary Y. Gao, Joseph F. Boggs, Pamela J. Bennett, Jane C. Martin, Mary Ann Rose, Joseph W. Rimelspach, Randall H. Zondag and William E. Pound -- Wildlife problems in Ohio landscapes: 1997 / Gary Y. Gao, Joseph F. Boggs, Jane C. Martin, Charles T. Behnke and James A. Chatfield -- Summary of turf cultural and disease problems in 1997 / Gary Y. Gao, Joseph F. Boggs, Pamela J. Bennett, Jane C. Martin, Joseph W. Rimelspach and James A. Chatfield -- Master Gardeners serve Ohio / Marianne Riofrio -- The greening of Poland's nurseries / Kenneth D. Cochran and Wojtek Grabczewski -- The marketing potential of Ginkgo biloba in the United States / Kenneth D. Cochran -- Composts in the Landscape: Effects on Soil pH and plant growth / Mary Ann Rose and Hao Wang -- How to optimize disease control using composts / Harry A. J. Hoitink, Wei-Zheng Zhang, David Y. Han, Alexandra G. Stone, Matthew S. Krause and Warren A. Dick -- The flowering sequence of ornamental plants as a tool for predicting the phenology of insect pests / Daniel A. Herms -- Reducing maintenance costs may mean selecting plants with the fewest flaws / T. Davis Sydnor-- Comprehensive aesthetic evaluations of crabapples at Secrest Arboretum in Wooster: 1993-1997 / Erik A. Draper, James A. Chatfield, Kenneth D. Cochran, Peter W. Bristol and David E. Allen -- Precision control of microirrigation for container-grown mini-roses / Robert C. Hansen, Ted H. Short, C. C. Pasian and R. Peter Fynn -- Red thread (Laetisaria fuciformis) control study on perennial ryegrass / Joseph W. Rimelspach, Kerry Kline, Karl Danneberger and Michael Boehm-- Red thread (Laetisaria fuciformis) control study on Kentucky bluegrass / Joseph W. Rimelspach, Kerry Kline, Karl Danneberger and Michael Boehm -- Red thread - from novelty to nuisance / Joseph W. Rimelspach -- Chrysanthemum cultivars differ in response to photoperiod when grown under far-red absorbing filters / M. J. McMahon -- Improving fuchsia cutting performance by grafting / D. M. Napier and M. J. McMahon -- Paint/paclobutrazol mix on the inside surface of rooting wedge cells to control poinsettia cutting height / Claudio C. Pasian -- Response of poinsettias to paclobutrazol in paint applications / Claudio C. Pasian and Daniel K. Struve -- Dynamic transpiration of highly stressed container-grown Acer rubrum / Ted H. Short, Ahmet Irvem and Robert C. Hansen -- Effects of temperature on the development of Asiatic Lilies / J. Steininger and C. C. Pasian-- New publications for 1997-199

Decolonizing Science and Science Education in a Postcolonial Space (Trinidad, a Developing Caribbean Nation, Illustrates)

The article addresses how remnant or transformed colonialist structures continue to shape science and science education, and how that impact might be mitigated within a postcolonial environment in favor of the development of the particular community being addressed. Though cognizant of, and resistant to, the ongoing colonial impact globally and nationally (and any attempts at subjugation, imperialism, and marginalization), this article is not about anticolonial science. Indeed, it is realized that the postcolonial state of science and science education is not simply defined, and may exist as a mix of the scientific practices of the colonizer and the colonized. The discussion occurs through a generic postcolonial lens and is organized into two main sections. First, the discussion of the postcolonial lens is eased through a consideration of globalization which is held here as the new colonialism. The article then uses this lens to interrogate conceptions of science and science education, and to suggest that the mainstream, standard account of what science is seems to represent a globalized- or arguably a Western, modern, secular-conception of science. This standard account of science can act as a gatekeeper to the indigenous ways of being, knowing, and doing of postcolonial populations. The article goes on to suggest that as a postcolonial response, decolonizing science and science education might be possible through practices that are primarily contextually respectful and responsive. That is, localization is suggested as one possible antidote to the deleterious effects of globalization. Trinidad, a postcolonial developing Caribbean nation, is used as illustration

CHARITY: Chagas cardiomyopathy bisoprolol intervention study: a randomized double-blind placebo force-titration controlled study with Bisoprolol in patients with chronic heart failure secondary to Chagas cardiomyopathy [NCT00323973]

BACKGROUND: Chagas' disease is the major cause of disability secondary to tropical diseases in young adults from Latin America, and around 20 million people are currently infected by T. cruzi. Heart failure due to Chagas cardiomyopathy is the main clinical presenation in Colombia. Heart failure due to Chagas' disease may respond to digoxin, diuretics and vasodilator therapy. Beta-adrenoreceptor antagonism seems to protect against the increased risk of cardiac arrhythmia and sudden death due to chronic sympathetic stimulation. The aim of this study is to evaluate the effects of the selective beta-adrenergic receptor blocker Bisoprolol on cardiovascular mortality, hospital readmission due to progressive heart failure and functional status in patients with heart failure secondary to Chagas' cardiomyopathy. METHODS/DESIGN: A cohort of 500 T. cruzi seropositive patients (250 per arm) will be selected from several institutions in Colombia. During the pretreatment period an initial evaluation visit will be scheduled in which participants will sign consent forms and baseline measurements and tests will be conducted including blood pressure measurements, twelve-lead ECG and left ventricular ejection fraction assessment by 2D echocardiography. Quality of life questionnaire will be performed two weeks apart during baseline examination using the "Minnesota living with heart failure" questionnaire. A minimum of two 6 minutes corridor walk test once a week over a two-week period will be performed to measure functional class. During the treatment period patients will be randomly assigned to receive Bisoprolol or placebo, initially taking a total daily dose of 2.5 mgrs qd. The dose will be increased every two weeks to 5, 7.5 and 10 mgrs qd (maximum maintenance dose). Follow-up assessment will include clinical check-up, and blood collection for future measurements of inflammatory reactants and markers. Quality of life measurements will be obtained at six months. This study will allow us to explore the effect of beta-blockers in chagas' cardiomyopathy