Navigating SEL From the Inside Out: Looking Inside & Across 18 Leading SEL Programs: A Practical Resource for Schools and OST ProvidersMiddle & High School Focus

The field of social and emotional learning (SEL) is rapidly expanding, as evidence emerges that social and emotional skills have a positive impact on learning and life outcomes. This guide to evidence-based SEL programs provides detailed information on 18 middle and high school programs, encompassing curricular content and program highlights. School or out-of-school-time program practitioners interested in SEL can use the resource to look "inside and across" SEL programs to better understand their content and assess their fit with school district or community needs.?The guide was written by Harvard Graduate School of Education professor Stephanie Jones, an expert in social and emotional learning, and a team of researchers. It is a practical resource that provides profiles of each program, including the specific skills targeted and instructional methods used. Some programs, for example, are designed to help students regulate their behavior and build positive relationships, while others are aimed at developing certain mindsets or character traits.Much of the guide focuses on detailed program information, while introductory chapters discuss a range of topics, including SEL in out-of-school-time (OST) programming, equitable SEL and a trauma-sensitive approach to SEL.In addition to helping schools and OST providers make decisions about choosing a social and emotional learning program, the guide is designed to be a useful resource for those who want to better understand social and emotional learning and the landscape of available programs or assess the effectiveness of one they are already using. A supplement includes worksheets to help users select a program and think through considerations on everything from program components to program duration and cost.??Key components of the guide include: Background information on SEL and its benefits, including key features of effective programs and common implementation challenges, A summary of the evidence base for each of the 18 programs, Recommendations for adapting the programs to OST settings, Summary tables that allow users to compare unique features, program components, and instructional methods, as well as see which skills each program targets, and Detailed individual profiles for each of the programs

Infections disséminées à Scedosporium prolificans: à propos de 2 cas et revue de la littérature

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Apoptotic Mesenchymal Stromal Cells Support Osteoclastogenesis While Inhibiting Multinucleated Giant Cells Formation in Vitro

International audienceAbstract In bone regeneration induced by the combination of mesenchymal stromal cells (MSCs) and calcium-phosphate (CaP) materials, osteoclasts emerge as a pivotal cell linking inflammation and bone formation. Favorable outcomes are observed despite short-term engraftments of implanted MSCs, highlighting their major paracrine function and the possible implication of cell death in modulating their secretions. In this work, we focused on the communication from MSCs towards osteoclasts-like cells in vitro. MSCs seeded on a CaP biomaterial or undergoing induced apoptosis produced a conditioned media favoring the development of osteoclasts from human CD14+ monocytes. On the contrary, MSCs' apoptotic secretion inhibited the development of inflammatory multinucleated giant cells formed after IL-4 stimulation. Components of MSCs' secretome before and after apoptotic stress were compared using mass spectrometry-based quantitative proteomics and a complementary immunoassay for major cytokines. CXCR-1 and CXCR-2 ligands, primarily IL-8/CXCL-8 but also the growth-regulated proteins CXCL-1, -2 or -3, were suggested as the major players of MSCs' pro-osteoclastic effect. These findings support the hypothesis that osteoclasts are key players in bone regeneration and suggest that apoptosis plays an important role in MSCs' effectiveness

Magnetic resonance spectroscopy detects biochemical changes in the brain associated with chronic low back pain: A preliminary report

Magnetic resonance (MR) spectroscopy is a noninvasive technique that can be used to detect and measure the concentration of metabolites and neurotransmitters in the brain and other organs. We used in vivo 1H MR spectroscopy in subjects with low back pain compared with control subjects to detect alterations in biochemistry in three brain regions associated with pain processing. A pattern recognition approach was used to determine whether it was possible to discriminate accurately subjects with low back pain from control subjects based on MR spectroscopy. MR spectra were obtained from the prefrontal cortex, anterior cingulate cortex, and thalamus of 32 subjects with low back pain and 33 control subjects without pain. Spectra were analyzed and compared between groups using a pattern recognition method (Statistical Classification Strategy). Using this approach, it was possible to discriminate between subjects with low back pain and control subjects with accuracies of 100%, 99%, and 97% using spectra obtained from the anterior cingulate cortex, thalamus, and prefrontal cortex, respectively. These results demonstrate that MR spectroscopy, in combination with an appropriate pattern recognition approach, is able to detect brain biochemical changes associated with chronic pain with a high degree of accuracy

Autologous transplantation in CLL patients with B and C Binet stages: final results of the prospective randomized GOELAMS LLC 98 trial.

International audienceThe relevance of high-dose chemotherapy followed by auto-SCT in CLL remains to be defined. The aim of the prospective, randomized, GOELAMS LLC 98 trial was to compare two strategies in previously untreated CLL patients aged <60 years. Conventional chemotherapy (Arm A) consisted of six monthly courses of CHOP followed by six CHOP courses in every 3 months in those achieving a complete or PR. Arm A was compared with high-dose therapy with auto-SCT (Arm B), used as consolidation after three CHOP courses in case of CR or very good PR. A total of 86 patients were enrolled, of which 39 and 43 patients were evaluable in arm A and arm B, respectively. The primary endpoint was PFS. On an intent-to-treat basis and with a median follow-up time of 77.1 (range 1-135.5) months, the median PFS was 22 months in Arm A and 53 months in Arm B (P<0.0001). Median survival time was 104.7 months in arm A and 107.4 months in arm B. This trial demonstrates that frontline high-dose therapy with auto-SCT prolongs PFS but does not translate into a survival advantage in advanced CLL patients in the pre-rituximab era

Intrathecal liposomal cytarabine (lipoCIT) administration in patients with leukemic or lymphomatous meningitis: efficacy and long-term safety in a single institution.

International audienceBACKGROUND: There is limited information regarding the efficacy and long term safety of intrathecal injection of liposomal cytarabine in leukemic or lymphomatous meningitis. DESIGN AND METHODS: We studied 20 consecutive HIV-negative patients with leukemic or lymphomatous meningitis who were treated with intrathecal liposomal cytarabine between 2004 and 2007. We focused on efficacy and on any late effects of the drug. RESULTS: Twenty patients who received intrathecal liposomal cytarabine injection as part of their treatment; of these, 9 were alive and in complete remission at the end of the study. Median survival from the time of the first injection was 22.7 months (range, 0.5 to 64 months). Short-term toxicity related to intrathecal of liposomal cytarabine was observed in 2 cases; headache in 1 case and regressive facial palsy and diplopy in 1 case. Long-term toxicity was seen in 2 cases; clinical symptoms were urinary and fecal dysfunction with confusion in 1 case, and urinary dysfunction in 1 case. Both patients had been heavily pre-treated with neurotoxic drugs and neuraxis irradiation. CONCLUSION: In our experience, intrathecal liposomal cytarabine injections were convenient in the management of leukemic and lymphomatous meningitis, and can lead to long-term survival. Although neurotoxicity was rare, clinicians should exercise caution when retreatment is required in relapsing patients

Influence of internal and outdoor factors on filamentous fungal flora in hematology wards.

International audienceBACKGROUND: Nosocomial invasive filamentous fungi infections could result from inhalation of filamentous fungi conidia present in hospital environment. METHODS: The environmental fungal flora in 3 different hospital wards with similar air conditioning was prospectively studied during 30 months and compared to internal (presence of agranulocytosis patient, behavioral practices, activity, cleaning work) and outdoor factors (meteorologic data, outdoor fungi). The general preventive measures differed from one unit to another. RESULTS: The hematology wards with filamentous fungi preventive measures were significantly less contaminated than a conventional ward without specific measures. Internal and outdoor factors influenced the level of fungal flora. However, the influence of internal factors was greater in the conventional ward than in hematology wards. The variation of flora in the hospital environment was seasonal, and the level of this contamination in each ward was influenced by the meteorology. However, outdoor factors more readily explain the variations of fungal load in hematology than in the conventional ward. CONCLUSION: This study highlights that specific preventive measures participate significantly in the control of the filamentous fungal flora intensity due to internal factors but not those due to outdoor factors, stressing the importance of high-efficiency particulate air filtration in high-risk units

Salvage outcomes in patients with first relapse after fludarabine, cyclophosphamide, and rituximab for chronic lymphocytic leukemia: The French intergroup experience

International audienceThe optimal management of patients with relapsed chronic lymphocytic leukemia (CLL) is dictated by the type of prior therapy, duration of prior response, presence of genomic aberrations, age, and comorbidities. The patterns of relapses and the clinical outcomes of second-line options after fludarabine-cyclophosphamide-rituximab (FCR) is given as a frontline treatment are currently unknown. In this retrospective and non-randomized study, we report the outcomes of 132 patients from databases of 14 French CLL study group centers who needed a second-line treatment after FCR frontline. Bendamustine + rituximab (BR) was the most frequently used second-line regimen, followed by alemtuzumab-based regimens, R-CHOP, and FCR. Median progression-free survival (PFS) was 18 months after BR with a median overall survival (OS) not reached. We also found that response durations of < 36 months and the presence of del(17p) are critical factors that contribute to poor overall survival. BR appears to be an effective salvage regimen in our series, both in terms of progression-free and overall survival. Patients who relapsed less than 36 months after FCR have a poor outcome, not significantly different in this study from patients with early relapses less than 12 or 24 months

Amyloid Precursor Protein Regulates Neuronal Cholesterol Turnover Needed For Synaptic Activity

Neuronal function of Amyloid Precursor Protein (APP) that generates b-amyloid peptide remains largely unknown. Expression of human APP (hAPP) in primary cultures of rat neurons decreased HMG-CoA reductase mRNA levels and therefore cholesterol biosynthesis. However, in cultured astrocytes, expression of hAPP did not affect cholesterol biosynthesis. In the nervous system, synaptic transmission and plasticity are supported by synchronous calcium oscillations. These synchronous calcium oscillations are known to be generated by glutamatergic synapses, and are mainly mediated by L-type voltagedependent calcium channels. Recently, we have reported that expression of human APP in primary culture of rat cortical neurons leads to inhibition of calcium oscillations in all the cells of the network. Since spontaneous neuronal activity is known to be tightly control by cholesterol level in membranes, we wonder whether APP could regulate spontaneous calcium oscillation through a cholesterol dependant mechanism. Indeed, we showed in neurons, expression of hAPP decreased both HMG-CoA reductase and 24- S-cholesterol hydroxylase mRNA levels, leading to inhibition of both cholesterol synthesis and hydroxylation. Reinitiating cholesterol turnover in hAPP expressing neurons rescued synaptic activity reflected by calcium oscillations. Altogether, these results suggest that APP regulates neuronal cholesterol turnover needed for synaptic activity both in vitro and in vivo