The Optical Polarization and Warm Absorber in IRAS 17020+4544

We report the detection of ionized absorption in the ASCA spectrum of the narrow-line Seyfert 1 galaxy IRAS 17020+4544. Subsequent optical spectropolarimetry revealed high polarization increasing from 3% in the red to 5% in the blue, indicating electron or dust scattering as a likely origin. The broad emission line H$\alpha$ is somewhat less polarized than the continuum, supporting a location of the polarizing material within the AGN. The Balmer line decrement and reddened optical spectrum support the presence of a dusty warm absorber in this object. We compared the broad band optical polarization and ionized X-ray absorption of a collection of Seyfert 1 and 1.5 galaxies, excluding classes of objects that are likely to have significant neutral X-ray absorption. Warm absorber objects are generally more likely to have high optical polarization than objects with no detected ionized absorption. This result lends additional support to the idea that the warm absorber is associated with dust and implies either that dust transmission is responsible for at least part of the polarization or that the polarization is revealed because of the dimming of the optical spectrum. Spectropolarimetry of Seyfert 1s generally locates the scattering material inside the narrow-line region and often close to or within the broad line region, consistent with estimates of the location of the dusty warm absorber.Comment: 11 pages using (AASTeX) aaspp4.sty and 3 Postscript figures. Accepted for publication in Astrophysical Journal Letter

Transnationalism and Social Work Education

Transnational movements, networks, and relationships are everywhere in this “world on the move” (Williams & Graham, 2014, p. i1). Transnational peoples maintain relationships of interdependence and support with families and communities in their places of origin, often returning regularly, while starting new lives and making new connections. Transnationalism is characterized by mobilities and networks, by social integration, and by extended and extensive relationship ties of family, neighborhood, religious faith, or combinations thereof (Valtonen, 2008). While disciplines across the world including sociology, human geography, and cultural anthropology engage with the implications of transnationalism (Bauböck & Faist, 2010), social work in England and mainland Europe has not achieved similar levels of engagement. As Cox and Geisen state: “the social world is being transformed by migration and social work is playing catch-up” (2014, p. i162)

Screening for Future Cardiovascular Disease Using Age Alone Compared with Multiple Risk Factors and Age

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

Chemical modification of proteins is essential for a variety of important diagnostic and therapeutic applications. Many strategies developed to date lack chemo- and regioselectivity as well as result in non-native linkages that may suffer from instability in vivo and adversely affect the protein's structure and function. We describe here the reaction of N-nucleophiles with the amino acid dehydroalanine (Dha) in a protein context. When Dha is chemically installed in proteins, the addition of a wide-range N-nucleophiles enables the rapid formation of amine linkages (secondary and tertiary) in a chemoselective manner under mild, biocompatible conditions. These new linkages are stable at a wide range of pH values (pH 2.8 to 12.8), under reducing conditions (biological thiols such as glutathione) and in human plasma. This method is demonstrated for three proteins and is shown to be fully compatible with disulfide bridges, as evidenced by the selective modification of recombinant albumin that displays 17 structurally relevant disulfides. The practicability and utility of our approach is further demonstrated by the construction of a chemically modified C2A domain of Synaptotagmin-I protein that retains its ability to preferentially bind to apoptotic cells at a level comparable to the native protein. Importantly, the method was useful for building a homogeneous antibody-drug conjugate with a precise drug-to-antibody ratio of 2. The kinase inhibitor crizotinib was directly conjugated to Dha through its piperidine motif, and its antibody-mediated intracellular delivery results in 10-fold improvement of its cancer cell-killing efficacy. The simplicity and exquisite site-selectivity of the aza-Michael ligation described herein allows the construction of stable secondary and tertiary amine-linked protein conjugates without affecting the structure and function of biologically relevant proteins

Dual-modality gene reporter for in vivo imaging

The ability to track cells and their patterns of gene expression in living organisms can increase our understanding of tissue development and disease. Gene reporters for bioluminescence, fluorescence, radionuclide, and magnetic resonance imaging (MRI) have been described but these suffer variously from limited depth penetration, spatial resolution, and sensitivity. We describe here a gene reporter, based on the organic anion transporting protein Oatp1a1, which mediates uptake of a clinically approved, Gd(3+)-based, hepatotrophic contrast agent (gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid). Cells expressing the reporter showed readily reversible, intense, and positive contrast (up to 7.8-fold signal enhancement) in T1-weighted magnetic resonance images acquired in vivo. The maximum signal enhancement obtained so far is more than double that produced by MRI gene reporters described previously. Exchanging the Gd(3+) ion for the radionuclide, (111)In, also allowed detection by single-photon emission computed tomography, thus combining the spatial resolution of MRI with the sensitivity of radionuclide imaging

Polarimetry and Unification of Low-Redshift Radio Galaxies

We have made high-quality measurements of the polarization spectra of 13 FR II radio galaxies and taken polarization images for 11 of these with the Keck telescopes. Seven of the eight narrow-line radio galaxies (NLRG) are polarized, and six of the seven show prominent broad Balmer lines in polarized light. The broad lines are also weakly visible in total flux. Some of the NLRG show bipolar regions with roughly circumferential polarization vectors, revealing a large reflection nebula illuminated by a central source. Our observations powerfully support the hidden quasar hypothesis for some NLRG. Classification as NLRG, broad-line radio galaxy (BLRG), or quasar therefore depends on orientation. However, not all objects fit into this unification scheme. Our sample is biased towards objects known in advance to be polarized, but the combination of our results with those of Hill, Goodrich and DePoy (1996) show that at least 6 out of a complete, volume and flux-limited sample of 9 FR II NLRG have broad lines, seen either in polarization or P_alpha.Comment: To appear in November 1999 Astronomical Journal. 49 pages, 13 figure