A space station onboard scheduling assistant

One of the goals for the Space Station is to achieve greater autonomy, and have less reliance on ground commanding than previous space missions. This means that the crew will have to take an active role in scheduling and rescheduling their activities onboard, perhaps working from preliminary schedules generated on the ground. Scheduling is a time intensive task, whether performed manually or automatically, so the best approach to solving onboard scheduling problems may involve crew members working with an interactive software scheduling package. A project is described which investigates a system that uses knowledge based techniques for the rescheduling of experiments within the Materials Technology Laboratory of the Space Station. Particular attention is paid to: (1) methods for rapid response rescheduling to accommodate unplanned changes in resource availability, (2) the nature of the interface to the crew, (3) the representation of the many types of data within the knowledge base, and (4) the possibility of applying rule-based and constraint-based reasoning methods to onboard activity scheduling

Guidance algorithms for a free-flying space robot

Robotics is a promising technology for assembly, servicing, and maintenance of platforms in space. Several aspects of planning and guidance for telesupervised and fully autonomous robotic servicers are investigated. Guidance algorithms for proximity operation of a free flyer are described. Numeric trajectory optimization is combined with artificial intelligence based obstacle avoidance. An initial algorithm and the results of its simulating platform servicing scenario are discussed. A second algorithm experiment is then proposed

Triangular Ring Resonator: Direct measurement of the parity-odd parameters of the photon sector of SME

We introduce the the Triangular Ring (TR) resonator. We show that the difference between the clockwise and anti-clockwise resonant frequencies of a vacuum TR resonator is sensitive to the birefringence parity-odd parameters of the photon's sector of the minimal Standard Model Extension (mSME): the Standard Model plus all the perturbative parameters encoding the break the Lorentz symmetry. We report that utilizing the current technology allows for direct measurement of these parameters with a sensitivity of the parity even ones and improves the best current resonator bounds by couple of orders of magnitudes. We note that designing an optical table that rotates perpendicular to the gravitational equipotential surface (geoid) allows for direct measurement of the constancy of the light speed at the vicinity of the earth in all directions in particular perpendicular to the geoid. If this table could achieve the precision of the ordinary tables, then it would improve the GPS bounds on the constancy of the light speed perpendicular to geoid by about eight orders of magnitude.Comment: ref. added, minor corrections, matches the published versio

Spectropolarimetry of the Luminous Narrow-Line Seyfert Galaxies IRAS 20181-2244 and IRAS 13224-3809

We observed the narrow-line Seyfert 1 galaxies IRAS 20181-2244 and IRAS 13324-3809 with a new spectropolarimeter on the RC spectrograph at the CTIO 4m telescope. Previously it had been suggested that IRAS 20181-2244 was a Type 2 QSO and thus might contain an obscured broad-line region which could be detected by the presence of broad Balmer lines in the polarized flux. We found the object to be polarized at about 2%, and constant with wavelength, (unlike most narrow-line Seyfert 1s), but with no evidence of broad Balmer lines in polarized flux. The spectropolarimetry indicates that the scattering material is inside the BLR. IRAS 13224-3809, notable for its high variability in X-ray and UV wavelengths, has a low polarization consistent with a Galactic interstellar origin.Comment: 19 pages using (AASTEX) aaspp4.sty and 5 postscript figures To be published in the Astrophysical Journa

Is it Round? Spectropolarimetry of the Type II-P Supernova 1999em

We present the first multi-epoch spectropolarimetry of a type II plateau supernova (SN II-P), with optical observations of SN 1999em on days 7, 40, 49, 159, and 163 after discovery. These data are used to probe the geometry of the electron-scattering atmosphere before, during, and after the plateau phase, which ended roughly 90 days after discovery. Weak continuum polarization with an unchanging polarization angle (theta ~ 160 deg) is detected at all epochs, with p ~ 0.2% on day 7, p ~ 0.3% on days 40 and 49, and p ~ 0.5% in the final observations. Distinct polarization modulations across strong line features are present on days 40, 49, 159, and 163. Uncorrected for interstellar polarization (which is believed to be quite small), polarization peaks are associated with strong P Cygni absorption troughs and nearly complete depolarization is seen across the H-alpha emission profile. The temporal evolution of the continuum polarization and sharp changes across lines indicate polarization intrinsic to SN 1999em. When modeled in terms of the oblate, electron-scattering atmospheres of Hoeflich, the observed polarization implies anasphericity of at least 7% during the period studied. The temporal polarization increase may indicate greater asphericity deeper into the ejecta. We discuss the implications of asphericity on the use of type II-P supernovae as primary extragalactic distance indicators through the expanding photosphere method (EPM). If asphericity produces directionally dependant flux and peculiar galaxy motions are characterized by sigma_v_rec = 300 km/s, it is shown that the agreement between previous EPM measurements of SNe II and distances to the host galaxies predicted by a linear Hubble law restrict mean SN II asphericity to values less than 30% (3-sigma) during the photospheric phase.Comment: 65 pages (29 Figures, 4 Tables), Accepted for publication in the June 1, 2001 edition of ApJ. Revised statistical analysis of scatter in Hubble diagram of previous EPM distances and the implications for mean SN II asphericit

UV Spectropolarimetry of Narrow-line Radio Galaxies

We present the results of UV spectropolarimetry (2000 - 3000A) and far-UV spectroscopy (1500 - 2000A) of two low-redshift narrow-line radio galaxies (NLRGs) taken with the Faint Object Spectrograph onboard the Hubble Space Telescope (HST). Spectropolarimetry of several NLRGs has shown that, by the presence of broad permitted lines in polarized flux spectrum, they have hidden quasars seen through scattered light. Imaging polarimetry has shown that NLRGs including our targets often have large scattering regions of a few kpc to >~10 kpc scale. This has posed a problem about the nature of the scatterers in these radio galaxies. Their polarized continuum has the spectral index similar to or no bluer than that of quasars, which favors electrons as the dominant scattering particles. The large scattering region size, however, favors dust scattering, because of its higher scattering efficiency compared to electrons. In this paper, we investigate the polarized flux spectrum over a wide wavelength range, combining our UV data with previous optical/infrared polarimetry data. We infer that the scattering would be often caused by opaque dust clouds in the NLRGs and this would be a part of the reason for the apparently grey scattering. In the high-redshift radio galaxies, these opaque clouds could be the proto-galactic subunits inferred to be seen in the HST images. However, we still cannot rule out the possibility of electron scattering, which could imply the existence of a large gas mass surrounding these radio galaxies.Comment: 25 pages, 21 figures. To appear in Ap

Chemotherapy-Response Monitoring of Breast Cancer Patients Using Quantitative Ultrasound-Based Intra-Tumour Heterogeneities

© 2017 The Author(s). Anti-cancer therapies including chemotherapy aim to induce tumour cell death. Cell death introduces alterations in cell morphology and tissue micro-structures that cause measurable changes in tissue echogenicity. This study investigated the effectiveness of quantitative ultrasound (QUS) parametric imaging to characterize intra-tumour heterogeneity and monitor the pathological response of breast cancer to chemotherapy in a large cohort of patients (n = 100). Results demonstrated that QUS imaging can non-invasively monitor pathological response and outcome of breast cancer patients to chemotherapy early following treatment initiation. Specifically, QUS biomarkers quantifying spatial heterogeneities in size, concentration and spacing of acoustic scatterers could predict treatment responses of patients with cross-validated accuracies of 82 ± 0.7%, 86 ± 0.7% and 85 ± 0.9% and areas under the receiver operating characteristic (ROC) curve of 0.75 ± 0.1, 0.80 ± 0.1 and 0.89 ± 0.1 at 1, 4 and 8 weeks after the start of treatment, respectively. The patients classified as responders and non-responders using QUS biomarkers demonstrated significantly different survivals, in good agreement with clinical and pathological endpoints. The results form a basis for using early predictive information on survival-linked patient response to facilitate adapting standard anti-cancer treatments on an individual patient basis

A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate.

Dissolution dynamic nuclear polarization (DNP) enables the metabolism of hyperpolarized (13)C-labelled molecules, such as the conversion of [1-(13)C]pyruvate to [1-(13)C]lactate, to be dynamically and non-invasively imaged in tissue. Imaging of this exchange reaction in animal models has been shown to detect early treatment response and correlate with tumour grade. The first human DNP study has recently been completed, and, for widespread clinical translation, simple and reliable methods are necessary to accurately probe the reaction in patients. However, there is currently no consensus on the most appropriate method to quantify this exchange reaction. In this study, an in vitro system was used to compare several kinetic models, as well as simple model-free methods. Experiments were performed using a clinical hyperpolarizer, a human 3 T MR system, and spectroscopic imaging sequences. The quantitative methods were compared in vivo by using subcutaneous breast tumours in rats to examine the effect of pyruvate inflow. The two-way kinetic model was the most accurate method for characterizing the exchange reaction in vitro, and the incorporation of a Heaviside step inflow profile was best able to describe the in vivo data. The lactate time-to-peak and the lactate-to-pyruvate area under the curve ratio were simple model-free approaches that accurately represented the full reaction, with the time-to-peak method performing indistinguishably from the best kinetic model. Finally, extracting data from a single pixel was a robust and reliable surrogate of the whole region of interest. This work has identified appropriate quantitative methods for future work in the analysis of human hyperpolarized (13)C data.CJD is jointly funded by the National Institute for Health Research (NIHR), Cambridge Biomedical Research Centre and GlaxoSmithKline (GSK). Additional funding for this study was provided by Cancer Research UK (CRUK, C19212/A16628; C19212/A911376), The Wellcome Trust, Cambridge Experimental Cancer Medicine Centre, Cambridge Cancer Centre, the School of Clinical Medicine at the University of Cambridge and the CRUK and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre in Cambridge and Manchester.This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/nbm.346

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

Chemical modification of proteins is essential for a variety of important diagnostic and therapeutic applications. Many strategies developed to date lack chemo- and regioselectivity as well as result in non-native linkages that may suffer from instability in vivo and adversely affect the protein's structure and function. We describe here the reaction of N-nucleophiles with the amino acid dehydroalanine (Dha) in a protein context. When Dha is chemically installed in proteins, the addition of a wide-range N-nucleophiles enables the rapid formation of amine linkages (secondary and tertiary) in a chemoselective manner under mild, biocompatible conditions. These new linkages are stable at a wide range of pH values (pH 2.8 to 12.8), under reducing conditions (biological thiols such as glutathione) and in human plasma. This method is demonstrated for three proteins and is shown to be fully compatible with disulfide bridges, as evidenced by the selective modification of recombinant albumin that displays 17 structurally relevant disulfides. The practicability and utility of our approach is further demonstrated by the construction of a chemically modified C2A domain of Synaptotagmin-I protein that retains its ability to preferentially bind to apoptotic cells at a level comparable to the native protein. Importantly, the method was useful for building a homogeneous antibody-drug conjugate with a precise drug-to-antibody ratio of 2. The kinase inhibitor crizotinib was directly conjugated to Dha through its piperidine motif, and its antibody-mediated intracellular delivery results in 10-fold improvement of its cancer cell-killing efficacy. The simplicity and exquisite site-selectivity of the aza-Michael ligation described herein allows the construction of stable secondary and tertiary amine-linked protein conjugates without affecting the structure and function of biologically relevant proteins