Tumour-associated macrophages and oncolytic virotherapies:a mathematical investigation into a complex dynamics

Anti-cancer therapies based on oncolytic viruses are emerging as important approaches in cancer treatment. However, the effectiveness of these therapies depends significantly on the interactions between the oncolytic viruses and the host immune response. Macrophages are one of the most important cell types in the anti-viral immune responses, by acting as a first line of defence against infections. Here, we consider a mathematical approach to investigate the possible outcomes of the interactions between two extreme phenotypes of macrophages (M1 and M2 cells) and an oncolytic virus (VSV), in the context of B16F10 melanoma. We show that polarization towards either an M1 or M2 phenotype can enhance oncolytic virus therapy through either (i) anti-tumour immune activation, or (ii) enhanced oncolysis. Moreover, we show that tumour reduction and elimination does not depend only on the ratio of M1:M2 cells, but also on the number of tumour-infiltrating macrophages

MERLIN/VLA imaging of the gravitational lens system B0218+357

Gravitational lenses offer the possibility of accurately determining the Hubble parameter (H_0) over cosmological distances, and B0218+357 is one of the most promising systems for an application of this technique. In particular this system has an accurately measured time delay (10.5+/-0.4 d; Biggs et al. 1999) and preliminary mass modelling has given a value for H_0 of 69 +13/-19 km/s/Mpc. The error on this estimate is now dominated by the uncertainty in the mass modelling. As this system contains an Einstein ring it should be possible to constrain the model better by imaging the ring at high resolution. To achieve this we have combined data from MERLIN and the VLA at a frequency of 5 GHz. In particular MERLIN has been used in multi-frequency mode in order to improve substantially the aperture coverage of the combined data set. The resulting map is the best that has been made of the ring and contains many new and interesting features. Efforts are currently underway to exploit the new data for lensing constraints using the LensClean algorithm (Kochanek & Narayan 1992).Comment: Accepted for publication in MNRAS. 6 pages, 4 included PostScript figure

Coaxial Jets and Sheaths in Wide-Angle-Tail Radio Galaxies

We add 20, 6 and 3.6 cm wavelength VLA observations of two WATs, 1231+674 and 1433+553, to existing VLA data at 6 and 20 cm, in order to study the variations of spectral index as a function of position. We apply the spectral tomography process that we introduced in our analysis of 3C67, 3C190 and 3C449. Both spectral tomography and polarization maps indicate that there are two distinct extended components in each source. As in the case of 3C449, we find that each source has a flat spectrum jet surrounded by a steeper spectrum sheath. The steep components tend to be more highly polarized than the flat components. We discuss a number of possibilities for the dynamics of the jet/sheath systems, and the evolution of their relativistic electron populations. While the exact nature of these two coaxial components is still uncertain, their existence requires new models of jets in FR I sources and may also have implications for the dichotomy between FR Is and FR IIs.Comment: 29 text pages plus 13 figures. Scheduled for publication in May 10, 1999 Ap

Towards Precision LSST Weak-Lensing Measurement - I: Impacts of Atmospheric Turbulence and Optical Aberration

The weak-lensing science of the LSST project drives the need to carefully model and separate the instrumental artifacts from the intrinsic lensing signal. The dominant source of the systematics for all ground based telescopes is the spatial correlation of the PSF modulated by both atmospheric turbulence and optical aberrations. In this paper, we present a full FOV simulation of the LSST images by modeling both the atmosphere and the telescope optics with the most current data for the telescope specifications and the environment. To simulate the effects of atmospheric turbulence, we generated six-layer phase screens with the parameters estimated from the on-site measurements. For the optics, we combined the ray-tracing tool ZEMAX and our simulated focal plane data to introduce realistic aberrations and focal plane height fluctuations. Although this expected flatness deviation for LSST is small compared with that of other existing cameras, the fast f-ratio of the LSST optics makes this focal plane flatness variation and the resulting PSF discontinuities across the CCD boundaries significant challenges in our removal of the systematics. We resolve this complication by performing PCA CCD-by-CCD, and interpolating the basis functions using conventional polynomials. We demonstrate that this PSF correction scheme reduces the residual PSF ellipticity correlation below 10^-7 over the cosmologically interesting scale. From a null test using HST/UDF galaxy images without input shear, we verify that the amplitude of the galaxy ellipticity correlation function, after the PSF correction, is consistent with the shot noise set by the finite number of objects. Therefore, we conclude that the current optical design and specification for the accuracy in the focal plane assembly are sufficient to enable the control of the PSF systematics required for weak-lensing science with the LSST.Comment: Accepted to PASP. High-resolution version is available at http://dls.physics.ucdavis.edu/~mkjee/LSST_weak_lensing_simulation.pd

Inverse Compton Scattering as the Source of Diffuse EUV Emission in the Coma Cluster of Galaxies

We have examined the hypothesis that the majority of the diffuse EUV flux in the Coma cluster is due to inverse Compton scattering of low energy cosmic ray electrons (0.16 < epsilon < 0.31 GeV) against the 3K black-body background. We present data on the two-dimensional spatial distribution of the EUV flux and show that these data provide strong support for a non-thermal origin for the EUV flux. However, we show that this emission cannot be produced by an extrapolation to lower energies of the observed synchrotron radio emitting electrons and an additional component of low energy cosmic ray electrons is required.Comment: 11 pages, 5 figure

The Bologna Complete Sample of Nearby Radio Sources

We present a new, complete, sample of 95 radio sources selected from the B2 and 3CR catalogues, with z < 0.1. Since no selection effect on the core radio power, jet velocity, or source orientation is present, this sample is well suited for statistical studies. In this first paper we present the observational status of all sources on the parsec (mas) and kiloparsec (arcsec) scale; we give new parsec-scale data for 28 sources and discuss their parsec-scale properties. Combining these data with those in the literature, information on the parsec-scale morphology is available for a total of 53 radio sources with different radio power and kpc-scale morphology. We investigate their properties. We find a dramatically higher fraction of two-sided sources in comparison to previous flux limited VLBI surveys.Comment: 29 pages, 21 figures - ApJ in press (10 Jan 2005 issue

Probing dark energy with cluster counts and cosmic shear power spectra: including the full covariance

(Abridged) Combining cosmic shear power spectra and cluster counts is powerful to improve cosmological parameter constraints and/or test inherent systematics. However they probe the same cosmic mass density field, if the two are drawn from the same survey region, and therefore the combination may be less powerful than first thought. We investigate the cross-covariance between the cosmic shear power spectra and the cluster counts based on the halo model approach, where the cross-covariance arises from the three-point correlations of the underlying mass density field. Fully taking into account the cross-covariance as well as non-Gaussian errors on the lensing power spectrum covariance, we find a significant cross-correlation between the lensing power spectrum signals at multipoles l~10^3 and the cluster counts containing halos with masses M>10^{14}Msun. Including the cross-covariance for the combined measurement degrades and in some cases improves the total signal-to-noise ratios up to plus or minus 20% relative to when the two are independent. For cosmological parameter determination, the cross-covariance has a smaller effect as a result of working in a multi-dimensional parameter space, implying that the two observables can be considered independent to a good approximation. We also discuss that cluster count experiments using lensing-selected mass peaks could be more complementary to cosmic shear tomography than mass-selected cluster counts of the corresponding mass threshold. Using lensing selected clusters with a realistic usable detection threshold (S/N~6 for a ground-based survey), the uncertainty on each dark energy parameter may be roughly halved by the combined experiments, relative to using the power spectra alone.Comment: 32 pages, 15 figures. Revised version, invited original contribution to gravitational lensing focus issue, New Journal of Physic

Simulating cosmic rays in clusters of galaxies - II. A unified scheme for radio halos and relics with predictions of the gamma-ray emission

The thermal plasma of galaxy clusters lost most of its information on how structure formation proceeded as a result of dissipative processes. In contrast, non-equilibrium distributions of cosmic rays (CR) preserve the information about their injection and transport processes and provide thus a unique window of current and past structure formation processes. This information can be unveiled by observations of non-thermal radiative processes, including radio synchrotron, hard X-ray, and gamma-ray emission. To explore this, we use high-resolution simulations of a sample of galaxy clusters spanning a mass range of about two orders of magnitudes, and follow self-consistent CR physics on top of the radiative hydrodynamics. We model CR electrons that are accelerated at cosmological structure formation shocks and those that are produced in hadronic interactions of CRs with ambient gas protons. We find that CR protons trace the time integrated non-equilibrium activities of clusters while shock-accelerated CR electrons probe current accretion and merging shock waves. The resulting inhomogeneous synchrotron emission matches the properties of observed radio relics. We propose a unified model for the generation of radio halos. Giant radio halos are dominated in the centre by secondary synchrotron emission with a transition to the synchrotron radiation emitted from shock-accelerated electrons in the cluster periphery. This model is able to explain the observed correlation of mergers with radio halos, the larger peripheral variation of the spectral index, and the large scatter in the scaling relation between cluster mass and synchrotron emission. Future low-frequency radio telescopes (LOFAR, GMRT, MWA, LWA) are expected to probe the accretion shocks of clusters. [abridged]Comment: 32 pages, 19 figures, small changes to match the version to be published by MNRAS, full resolution version available at http://www.cita.utoronto.ca/~pfrommer/Publications/CRs_non-thermal.pd

Multifrequency VLA observations of the FR I radio galaxy 3C 31: morphology, spectrum and magnetic field

We present high-quality VLA images of the FR I radio galaxy 3C 31 in the frequency range 1365 to 8440 MHz with angular resolutions from 0.25 to 40 arcsec. Our new images reveal complex, well resolved filamentary substructure in the radio jets and tails. We also use these images to explore the spectral structure of 3C 31 on large and small scales. We infer the apparent magnetic field structure by correcting for Faraday rotation. Some of the intensity substructure in the jets is clearly related to structure in their apparent magnetic field: there are arcs of emission where the degree of linear polarization increases, with the apparent magnetic field parallel to the ridges of the arcs. The spectral indices are significantly steeper (0.62) within 7 arcsec of the nucleus than between 7 and 50 arcsec (0.52 - 0.57). The spectra of the jet edges are also slightly flatter than the average for their surroundings. At larger distances, the jets are clearly delimited from surrounding larger-scale emission both by their flatter radio spectra and by sharp brightness gradients. The spectral index of 0.62 in the first 7 arcsec of 3C 31's jets is very close to that found in other FR I galaxies where their jets first brighten in the radio and where X-ray synchrotron emission is most prominent. Farther from the nucleus, where the spectra flatten, X-ray emission is fainter relative to the radio. The brightest X-ray emission from FR I jets is therefore not associated with the flattest radio spectra, but with a particle-acceleration process whose characteristic energy index is 2.24. The spectral flattening with distance from the nucleus occurs where our relativistic jet models require deceleration, and the flatter-spectra at the jet edges may be associated with transverse velocity shear. (Slightly abridged)Comment: 17 pages, 13 figures, accepted for publication in MNRA

Resonant Kelvin-Helmholtz modes in sheared relativistic flows

Qualitatively new aspects of the (linear and non-linear) stability of sheared relativistic (slab) jets are analyzed. The linear problem has been solved for a wide range of jet models well inside the ultrarelativistic domain (flow Lorentz factors up to 20; specific internal energies $\approx 60c^2$). As a distinct feature of our work, we have combined the analytical linear approach with high-resolution relativistic hydrodynamical simulations, which has allowed us i) to identify, in the linear regime, resonant modes specific to the relativistic shear layer ii) to confirm the result of the linear analysis with numerical simulations and, iii) more interestingly, to follow the instability development through the non-linear regime. We find that very high-order reflection modes with dominant growth rates can modify the global, long-term stability of the relativistic flow. We discuss the dependence of these resonant modes on the jet flow Lorentz factor and specific internal energy, and on the shear layer thickness. The results could have potential applications in the field of extragalactic relativistic jets.Comment: Accepted for publication in Physical Review E. For better quality images, please check http://www.mpifr-bonn.mpg.de/staff/mperucho/Research.htm