The expanding bipolar shell of the helium nova V445 Puppis

From multi-epoch adaptive optics imaging and integral field unit spectroscopy, we report the discovery of an expanding and narrowly confined bipolar shell surrounding the helium nova V445 Puppis (Nova Puppis 2000). An equatorial dust disc obscures the nova remnant, and the outflow is characterized by a large polar outflow velocity of 6720 +/- 650 km s(-1) and knots moving at even larger velocities of 8450 +/- 570 km s(-1). We derive an expansion parallax distance of 8.2 +/- 0.5 kpc and deduce a pre-outburst luminosity of the underlying binary of log L/L-circle dot = 4.34 +/- 0.36. The derived luminosity suggests that V445 Puppis probably contains a massive white dwarf accreting at high rate from a helium star companion making it part of a population of binary stars that potentially lead to supernova Ia explosions due to accumulation of helium-rich material on the surface of a massive white dwarf

High speed photometry of faint Cataclysmic Variables: IV. V356 Aql, Aqr1, FIRST J1023+0038, Ha 0242-2802, GI Mon, AO Oct, V972 Oph, SDSS 0155+00, SDSS 0233+00, SDSS 1240-01, SDSS 1556-00, SDSS 2050-05, FH Ser

We present results from high speed photometry of a further thirteen faint cataclysmic variables. V356 Aql (Nova Aql 1936) shows flare-like outbursts with recurrence time scales ~ 3000 s, but no coherent periodicities. Aqr1 is an intermediate polar with a spin period of 6.7284 min and a probable orbital period P(orb) = 3.226 h derived from orbital sidebands. Its orbital sideband frequencies show very variable amplitudes. The published spectroscopic period of 2.0 h suggests that Aqr1 is similar to GW Lib and FS Aur in having an additional periodicity of unknown origin. FIRST J1023+0038 has P(orb) = 4.7548 h with an orbital modulation of range 0.45 mag, probably caused by reflection effect from a hot white dwarf primary; as such it may have been a nova sometime in the past few decades. Ha 0242 is a deeply eclipsing very low mass-transfer rate system, probably a dwarf nova of very long outburst interval, with P(orb) = 1.792 h. GI Mon, an old nova, has optical modulations at 4.325 h and possibly also at 48.6 min and is thus a candidate intermediate polar. AO Oct, an SU UMa type dwarf nova, shows orbital modulation at quiescence with P(orb) = 94.097 min. V972 Oph (Nova Ophiuchi 1957) showed no flickering activity during one set of observations, but did so at a later time, confirming the correctness of the identification of this object, but it shows no orbital modulation. SDSS 0155 is a deeply eclipsing polar with an orbital period of 87.13 min. SDSS 0233 shows flaring activity but no discernible periodicity. No periodicity was found in the new AM CVn candidate SDSS 1240. SDSS 1556 shows a periodic modulation at 1.778 h which is possibly due to orbital motion. SDSS 2050 is an eclipsing polar with P(orb) = 1.5702 h. FH Ser (Nova Serpentis 1970) has strong flickering activity but no detectable orbital modulation.Comment: 12 pages, 22 figures (Figs. 1, 2, 5 and 6 are available at higher resolution upon request). Accepted for publication in MNRA

Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study

Introduction: Influenza accounts for 5 to 10% of community-acquired pneumonias and is a major cause of mortality. Sterile and bacterial lung injuries are associated with procoagulant and inflammatory derangements in the lungs. Activated protein C (APC) is an anticoagulant with anti-inflammatory properties that exert beneficial effects in models of lung injury. We determined the impact of lethal influenza A (H1N1) infection on systemic and pulmonary coagulation and inflammation, and the effect of recombinant mouse (rm-) APC hereon. Methods: Male C57BL/6 mice were intranasally infected with a lethal dose of a mouse adapted influenza A (H1N1) strain. Treatment with rm-APC (125 mu g intraperitoneally every eight hours for a maximum of three days) or vehicle was initiated 24 hours after infection. Mice were euthanized 48 or 96 hours after infection, or observed for up to nine days. Results: Lethal H1N1 influenza resulted in systemic and pulmonary activation of coagulation, as reflected by elevated plasma and lung levels of thrombin-antithrombin complexes and fibrin degradation products. These procoagulant changes were accompanied by inhibition of the fibrinolytic response due to enhanced release of plasminogen activator inhibitor type-1. Rm-APC strongly inhibited coagulation activation in both plasma and lungs, and partially reversed the inhibition of fibrinolysis. Rm-APC temporarily reduced pulmonary viral loads, but did not impact on lung inflammation or survival. Conclusions: Lethal influenza induces procoagulant and antifibrinolytic changes in the lung which can be partially prevented by rm-APC treatmen

Political strategies of external support for democratization

Political strategies of external support to democratization are contrasted and critically examined in respect of the United States and European Union. The analysis begins by defining its terms of reference and addresses the question of what it means to have a strategy. The account briefly notes the goals lying behind democratization support and their relationship with the wider foreign policy process, before considering what a successful strategy would look like and how that relates to the selection of candidates. The literature's attempts to identify strategy and its recommendations for better strategies are compared and assessed. Overall, the article argues that the question of political strategies of external support for democratization raises several distinct but related issues including the who?, what?, why?, and how? On one level, strategic choices can be expected to echo the comparative advantage of the "supporter." On a different level, the strategies cannot be divorced from the larger foreign policy framework. While it is correct to say that any sound strategy for support should be grounded in a theoretical understanding of democratization, the literature on strategies reveals something even more fundamental: divergent views about the nature of politics itself. The recommendations there certainly pinpoint weaknesses in the actual strategies of the United States and Europe but they have their own limitations too. In particular, in a world of increasing multi-level governance strategies for supporting democratization should go beyond preoccupation with just an "outside-in" approach

Trapping \u3ci\u3ePhyllophaga \u3c/i\u3espp. (Coleoptera: Scarabaeidae: Melolonthinae) in the United States and Canada using sex attractants.

The sex pheromone of the scarab beetle, Phyllophaga anxia, is a blend of the methyl esters of two amino acids, L-valine and L-isoleucine. A field trapping study was conducted, deploying different blends of the two compounds at 59 locations in the United States and Canada. More than 57,000 males of 61 Phyllophaga species (Coleoptera: Scarabaeidae: Melolonthinae) were captured and identified. Three major findings included: (1) widespread use of the two compounds [of the 147 Phyllophaga (sensu stricto) species found in the United States and Canada, males of nearly 40% were captured]; (2) in most species intraspecific male response to the pheromone blends was stable between years and over geography; and (3) an unusual pheromone polymorphism was described from P. anxia. Populations at some locations were captured with L-valine methyl ester alone, whereas populations at other locations were captured with L-isoleucine methyl ester alone. At additional locations, the L-valine methyl ester-responding populations and the L-isoleucine methyl ester-responding populations were both present, producing a bimodal capture curve. In southeastern Massachusetts and in Rhode Island, in the United States, P. anxia males were captured with blends of L-valine methyl ester and L-isoleucine methyl ester

Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo

Meeting Abstracts: Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo Clearwater Beach, FL, USA. 9-11 June 201

Protocol to Assess the Biological Activity of Insulin Glargine, Insulin Lispro, and Insulin Aspart In Vitro

Insulin is a hormone produced by β-cells of the pancreas and controls the amount of sugar in the blood. Since its discovery over 100 years ago, insulin has been used as a life-saving treatment for people with diabetes. Historically, the biological activity or bioidentity of insulin products has been assessed using an in vivo model. However, reduction in animal experiments is a goal for many worldwide, and there is a need to develop in vitro bioassays to reliably test the biological activity of insulin products. This article describes an in vitro cell-based method to assess the biological activity of insulin glargine, insulin aspart, and insulin lispro in a step-by-step manner