U.S. Law of the Sea Cruise to Complete the Mapping of Necker Ridge, Central Pacific Ocean

U.S. Law of the Sea Cruise to Complete the Mapping of Necker Ridge, Central Pacific Ocean CRUISE KM1121 July 31, to August 10, 2011 Honolulu, HI to Honolulu, H

U.S. Law of the Sea Cruise to Map the Foot of the Slope of the Northeast U.S. Atlantic Continental Margin: Leg 6

U.S. Law of the Sea Cruise to Map the Foot of the Slope of the Northeast U.S. Atlantic Continental Margin: Leg 6 Cruise KNOX17RR May 1 – 31, 2008 Ft. Lauderdale, FL to Woods Hole, M

U.S. Law of the Sea Cruise to Map the Southern Flank of the Kingman Reef-Palmyra Atoll section of the Line Islands, Equatorial Pacific Ocean

U.S. Law of the Sea Cruise to Map the Southern Flank of the Kingman Reef-Palmyra Atoll section of the Line Islands, Equatorial Pacific Ocean CRUISE KM1009 May 17, to June 16, 2010 Pago Pago, American Samoa to Honolulu, H

Multi-objective/loading optimization for rotating composite flexbeams

With the evolution of advanced composites, the feasibility of designing bearingless rotor systems for high speed, demanding maneuver envelopes, and high aircraft gross weights has become a reality. These systems eliminate the need for hinges and heavily loaded bearings by incorporating a composite flexbeam structure which accommodates flapping, lead-lag, and feathering motions by bending and twisting while reacting full blade centrifugal force. The flight characteristics of a bearingless rotor system are largely dependent on hub design, and the principal element in this type of system is the composite flexbeam. As in any hub design, trade off studies must be performed in order to optimize performance, dynamics (stability), handling qualities, and stresses. However, since the flexbeam structure is the primary component which will determine the balance of these characteristics, its design and fabrication are not straightforward. It was concluded that: pitchcase and snubber damper representations are required in the flexbeam model for proper sizing resulting from dynamic requirements; optimization is necessary for flexbeam design, since it reduces the design iteration time and results in an improved design; and inclusion of multiple flight conditions and their corresponding fatigue allowables is necessary for the optimization procedure

Explaining Regional and Local Differences in Organic Farming in England and Wales: A Comparison of South West Wales and South East England

Explaining regional and local differences in organic farming in England and Wales: a comparison of South West Wales and South East England, Regional Studies, Few studies explain the concentration of organic farming in specific regions of England and Wales. This paper compares the development of organic farming in South West Wales and South East England. While the focus in the former is on the use of mainly national marketing channels and the movement of organic produce more than 60 min from the farm, in the latter greater use is made of local and direct marketing channels to distribute organic food within 30 min of the farm. The overriding importance of demand appears to provide a key explanation for regional differentiation in organic farming. 解释英格兰与威尔斯有机农业的区域及地方差异：西南威尔斯与东南英格兰的比较研究，区域研究。显少有研究解释有机农业在英格兰及威尔斯特定区域中的集中现象。本文比较有机农业在西南威尔斯与东南英格兰的发展。西南威尔斯的发展重点，主要在于利用全国行销通路，以及距离农场超过六十分钟的有机产品运送路程，东南英格兰则较着重运用在地且直接的行销通路，在距离农场三十分钟以内的运送路程中分派有机食品。需求的压倒性重要性，似乎提供了有机农业中的区域差异的关键解释。 Expliquer les disparités régionales dans l'agriculture biologique en Angleterre et au pays de Galles: une comparaison du sud-ouest du pays de Galles et du sud-est de l'Angleterre, Regional Studies. Rares sont les études qui expliquent la concentration de l'agriculture biologique dans des zones spécifiques de l'Angleterre et du pays de Galles. Cet article cherche à comparer le développement de l'agriculture biologique du sud-ouest du pays de Galles à celle du sud-est de l'Angleterre. Tandis que celle-là met l'accent sur l'emploi des circuits commerciaux principalement nationaux et sur la distribution de la production agricole biologique à plus de 60 minutes de la ferme, celle-ci exploite davantage les circuits commerciaux locaux et directs pour distribuer les denrées alimentaires organiques dans un rayon de 30 minutes de la ferme. Il semble que l'importance primordiale de la demande constitue un facteur déterminant de la différenciation régionale de l'agriculture biologique. Erklärung der regionalen und lokalen Unterschiede bei der ökologischen Landwirtschaft in England und Wales: ein Vergleich zwischen Südwestwales und Südostengland, Regional Studies. Die Konzentration der ökologischen Landwirtschaft in bestimmten Regionen von England und Wales wird nur in wenigen Studien erklärt. In diesem Beitrag vergleichen wir die Entwicklung der ökologischen Landwirtschaft in Südwestwales mit der von Südostengland. Während in Südwestwales der Schwerpunkt auf den größtenteils landesweiten Absatzkanälen und dem Transport von ökologischen Lebensmitteln an mehr als 60 Minuten vom landwirtschaftlichen Betrieb entfernte Orte liegt, werden in Südostengland öfter lokale und direkte Absatzkanäle genutzt und die ökologischen Lebensmittel an bis zu 30 Minuten vom landwirtschaftlichen Betrieb entfernte Orte transportiert. Die wichtigste Erklärung für die regionalen Unterschiede bei der ökologischen Landwirtschaft scheinen in der vorrangigen Bedeutung der Nachfrage zu liegen. Explicación de las diferencias regionales y locales en la agricultura biológica de Inglaterra y Gales: comparación entre el suroeste de Gales y el sureste de Inglaterra, Regional Studies. En pocos estudios se explica la concentración de la agricultura biológica en regiones específicas de Inglaterra y Gales. En este artículo comparamos el desarrollo de la agricultura biológica en el suroeste de Gales y el sureste de Inglaterra. Mientras que en el suroeste de Gales se hace hincapié en el uso de canales mercantiles principalmente nacionales y el movimiento de productos biológicos a una distancia de más de 60 minutos de la explotación agrícola, en el sureste de Inglaterra se utilizan más los canales mercantiles locales y directos para distribuir alimentos biológicos a no más de 30 minutos de la explotación agrícola. Parece ser que la demanda es el motivo más importante para explicar las diferencias regionales en la agricultura biológica

Evidence of a Plasmoid-Looptop Interaction and Magnetic Inflows During a Solar Flare/CME Eruptive Event

Observational evidence is presented for the merging of a downward-propagating plasmoid with a looptop kernel during an occulted limb event on 2007 January 25. RHESSI lightcurves in the 9-18 keV energy range, as well as that of the 245 MHz channel of the Learmonth Solar Observatory, show enhanced nonthermal emission in the corona at the time of the merging suggesting that additional particle acceleration took place. This was attributed to a secondary episode of reconnection in the current sheet that formed between the two merging sources. RHESSI images were used to establish a mean downward velocity of the plasmoid of 12 km/s. Complementary observations from the SECCHI suite of instruments onboard STEREO-Behind showed that this process occurred during the acceleration phase of the associated CME. From wavelet-enhanced EUVI, images evidence of inflowing magnetic field lines prior to the CME eruption is also presented. The derived inflow velocity was found to be 1.5 km/s. This combination of observations supports a recent numerical simulation of plasmoid formation, propagation and subsequent particle acceleration due to the tearing mode instability during current sheet formation.Comment: 8 pages, 9 figures, ApJ (Accepted

Seafloor mapping in the Arctic: support for a potential U.S. extended continental shelf

For the United States, the greatest opportunity for an extended continental shelf under UNCLOS is in the ice-covered regions of the Arctic north of Alaska. Since 2003, CCOM/JHC has been using the icebreaker Healy equipped with a multibeam echosounder, chirp subbottom profiler, and dredges, to map and sample the region of Chukchi Borderland and Alpha-Mendeleev Ridge complex. These data have led to the discovery of several new features, have radically changed our view of the bathymetry and geologic history of the area, and may have important ramifications for the determination of the limits of a U.S. extended continental shelf under Article 76

Brain natriuretic peptide in pulmonary arterial hypertension: biomarker and potential therapeutic agent

B-type natriuretic peptide (BNP) is a member of the natriuretic peptide family, a group of widely distributed, but evolutionarily conserved, polypeptide mediators that exert myriad cardiovascular effects. BNP is a potent vasodilator with mitogenic, hypertrophic and pro-inflammatory properties that is upregulated in pulmonary hypertensive diseases. Circulating levels of BNP correlate with mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) in patients with pulmonary arterial hypertension (PAH). Elevated plasma BNP levels are associated with increased mortality in patients with PAH and a fall in BNP levels after therapy is associated with improved survival. These findings have important clinical implications in that a noninvasive blood test may be used to identify PAH patients at high-risk of decompensation and to guide pulmonary vasodilator therapy. BNP also has several biologic effects that could be beneficial to patients with PAH. However, lack of a convenient method for achieving sustained increases in circulating BNP levels has impeded the development of BNP as a therapy for treating pulmonary hypertension. New technologies that allow transdermal or oral administration of the natriuretic peptides have the potential to greatly accelerate research into therapeutic use of BNP for cor pulmonale and pulmonary vascular diseases. This review will examine the basic science and clinical research that has led to our understanding of the role of BNP in cardiovascular physiology, its use as a biomarker of right ventricular function and its therapeutic potential for managing patients with pulmonary vascular disease

Ambrisentan for the treatment of pulmonary arterial hypertension

Ambrisentan is an endothelin receptor antagonist (ERA) that was recently approved for treatment of pulmonary arterial hypertension (PAH). Endothelin (ET) is a potent vasoconstrictor with mitogenic, hypertrophic and pro-inflammatory properties that is upregulated in pulmonary hypertensive diseases. The biologic effects of ET are mediated by 2 cell surface receptors termed ETA and ETB. ETA mediates the vasoconstrictor effect of ET on vascular smooth muscle, whereas ETB is expressed primarily on vascular endothelial cells where it induces nitric oxide synthesis and acts to clear ET from the circulation. Ambrisentan is the first ETA selective ERA approved for use in the US. Recently published clinical trials in patients with PAH demonstrate improvement in functional capacity and pulmonary hemodynamics similar to other ETA selective and non-selective ERAs. Its once daily dosing and lower incidence of serum aminotransferase elevation offer potential advantages over other ERAs, but further experience with this agent is needed to fully understand its long-term efficacy and safety. This review discusses the endothelin family of proteins and receptors and their role in the pathophysiology of pulmonary hypertensive diseases. It also examines the development process, safety profile and clinical trials that have resulted in ambrisentan being approved for treatment of PAH