Study of Fluid Experiment System (FES)/CAST/Holographic Ground System (HGS)

The use of holographic and schlieren optical techniques for studying the concentration gradients in solidification processes has been used by several investigators over the years. The HGS facility at MSFC has been primary resource in researching this capability. Consequently, scientific personnel have been able to utilize these techniques in both ground based research and in space experiments. An important event in the scientific utilization of the HGS facilities was the TGS Crystal Growth and the casting and solidification technology (CAST) experiments that were flown on the International Microgravity Laboratory (IML) mission in March of this year. The preparation and processing of these space observations are the primary experiments reported in this work. This project provides some ground-based studies to optimize on the holographic techniques used to acquire information about the crystal growth processes flown on IML. Since the ground-based studies will be compared with the space-based experimental results, it is necessary to conduct sufficient ground based studies to best determine how the experiment worked in space. The current capabilities in computer based systems for image processing and numerical computation have certainly assisted in those efforts. As anticipated, this study has certainly shown that these advanced computing capabilities are helpful in the data analysis of such experiments

What\u27s on First?: Organizing the Casebook and Molding the Mind

This study empirically tests the proposition that law students adopt different conceptions of the judge’s role in adjudication based on whether they first study intentional torts, negligence, or strict liability. The authors conducted an anonymous survey of more than 450 students enrolled in eight law schools at the beginning, mid-point, and end of the first semester of law school. The students were prompted to indicate to what extent they believed the judge’s role to be one of rule application and, conversely, to what extent it was one of considering social, economic, and ideological factors. The survey found that while all three groups of students shifted toward a belief that judges consider social, economic, and ideological factors, the degree of the shift differed in a statistically significant way depending on which torts their professors taught first. These differences persisted throughout the semester, even after they studied other torts. Further, these differences were observed even when the analysis controlled for law school ranking and were more pronounced among students attending the highest ranked schools. In interpreting the survey results, the authors employ sociologist Erving Goffman’s theory of “frame analysis” and the work of cognitive psychologists including Amos Tversky and Daniel Kahneman on “anchoring.” The Article concludes that the category of tort liability to which students are first exposed affects the “frame” or “lens” through which they view the judicial process. This frame becomes anchored and persists throughout the study of other tort categories. The lessons about the nature of the judging process learned implicitly through the professor’s choice of topic sequence may be even more important than the substantive topics themselves

Evaluating default priors with a generalization of Eaton's Markov chain

We consider evaluating improper priors in a formal Bayes setting according to the consequences of their use. Let Φ be a class of functions on the parameter space and consider estimating elements of Φ under quadratic loss. If the formal Bayes estimator of every function in Φ is admissible, then the prior is strongly admissible with respect to Φ. Eaton’s method for establishing strong admissibility is based on studying the stability properties of a particular Markov chain associated with the inferential setting. In previous work, this was handled differently depending upon whether ϕ ∈ Φ was bounded or unbounded. We consider a new Markov chain which allows us to unify and generalize existing approaches while simultaneously broadening the scope of their potential applicability. We use our general theory to investigate strong admissibility conditions for location models when the prior is Lebesgue measure and for the p-dimensional multivariate Normal distribution with unknown mean vector θ and a prior of the form ν(‖θ‖²)dθ

External impacts on internal dynamics: Effects of paleoclimatic and demographic variability on acorn exploitation along the Central California coast

book chapterResearch into human-environment interaction in California prehistory often focuses on either the internal dynamics of adaptive decisions or the external impacts of environmental change. While both processes were surely driving prehistoric variability, integrating these approaches is not altogether straightforward. Here we outline an inclusive approach examining the exploitation of acorn habitats in Central California. Acorns were critically important to many ethnographic groups in Native California, but the intensive use of acorns appears to be a Late Holocene phenomenon. Most research approaches the increased reliance on acorns as a process governed by internal dynamics linked to demographically-driven resource intensification, but there are strong reasons to believe that climatic variability also structured acorn use. Here we link internal and external human-environmental dynamics through a formal behavioral ecological model. This model provides clear predictions that can be used to identify departures from expected internal dynamics linked to external factors driven by paleoenvironmental change. Results show that prehistoric occupation along the central California coast shifts into interior oak-dominated regions with increasing population densities, consistent with model expectations of internally-driven resource intensification. However, acorn use is also affected by climate: foragers are less likely to live in productive acorn habitats during periods of drought. These findings show that neither internal nor external patterns can completely account for variability in prehistoric decisions, but that integrating these through formal ecological models can provide insights into the external impacts on internal dynamics that structure broad patterns in prehistory

Environmental productivity predicts migration, demographic, and linguistic patterns in prehistoric California

Global patterns of ethnolinguistic diversity vary tremendously. Some regions show very little variation even across vast expanses, whereas others exhibit dense mosaics of different languages spoken alongside one another. Compared with the rest of Native North America, prehistoric California exemplified the latter. Decades of linguistic, genetic, and archaeological research have produced detailed accounts of the migrations that aggregated to build California’s diverse ethnolinguistic mosaic, but there have been few have attempts to explain the process underpinning these migrations and why such a mosaic did not develop elsewhere. Here we show that environmental productivity predicts both the order of migration events and the population density recorded at contact. The earliest colonizers occupied the most suitable habitats along the coast, whereas subsequent Mid–Late Holocene migrants settled in more marginal habitats. Other Late Holocene patterns diverge from this trend, reflecting altered dynamics linked to food storage and increased sedentism. Through repeated migration events, incoming populations replaced resident populations occurring at lower densities in lower-productivity habitats, thereby resulting in the fragmentation of earlier groups and the development of one of the most diverse ethnolinguistic patterns in the Americas. Such a process may account for the distribution of ethnolinguistic diversity worldwide

Bacterial community profiles and Vibrio parahaemolyticus abundance in individual oysters and their association with estuarine ecology

Oysters naturally harbor the human gastric pathogen Vibrio parahaemolyticus, but the nature of this association is unknown. Because microbial interactions could influence the accumulation of V. parahaemolyticus in oysters, we investigated the composition of the microbiome in water and oysters at two ecologically unique sites in the Great Bay Estuary, New Hampshire using 16s rRNA profiling. We then evaluated correlations between bacteria inhabiting the oyster with V. parahaemolyticus abundance quantified using a most probable number (MPN) analysis. Even though oysters filter-feed, their microbiomes were not a direct snapshot of the bacterial community in overlaying water, suggesting they selectively accumulate some bacterial phyla. The microbiome of individual oysters harvested more centrally in the bay were relatively more similar to each other and had fewer unique phylotypes, but overall more taxonomic and metabolic diversity, than the microbiomes from tributary-harvested oysters that were individually more variable with lower taxonomic and metabolic diversity. Oysters harvested from the same location varied in V. parahaemolyticus abundance, with the highest abundance oysters collected from one location. This study, which to our knowledge is the first of its kind to evaluate associations of V. parahaemolyticus abundance with members of individual oyster microbiomes, implies that sufficient sampling and depth of sequencing may reveal microbiome members that could impact V. parahaemolyticus abundance

The Regulation of Aggrecanase ADAMTS-4 Expression in Human Achilles Tendon and tendon-Derived Cells

Several members of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family have been identified as aggrecanases, whose substrates include versican, the principal large proteoglycan in the tendon extracellular matrix. We have characterized the expression of ADAMTS-4 in human Achilles tendon and tendon-derived cells. ADAMTS-4 mRNA levels were higher in ruptured tendon compared with normal tendon or chronic painful tendinopathy. In tissue extracts probed by Western blotting, mature ADAMTS-4 (68 kDa) was detected only in ruptured tendons, while processed ADAMTS-4 (53 kDa) was detected also in chronic painful tendinopathy and in normal tendon. In cultured Achilles tendon cells, transforming growth factor-ß (TGF-ß) stimulated ADAMTS-4 mRNA expression (typically 20-fold after 24 h), while interleukin-1 induced a smaller, shorter-term stimulation which synergised markedly with that induced by TGF-ß. Increased levels of immunoreactive proteins consistent with mature and processed forms of ADAMTS-4 were detected in TGF-ß-stimulated cells. ADAMTS-4 mRNA was expressed at higher levels by tendon cells in collagen gels than in monolayer cultures. In contrast, the expression of ADAMTS-1 and -5 mRNA was lower in collagen gels compared with monolayers, and these mRNA showed smaller or opposite responses to growth factors and cytokines compared with that of ADAMTS-4 mRNA. We conclude that both ADAMTS-4 mRNA and ADAMTS-4 protein processing may be differentially regulated in normal and damaged tendons and that both the matrix environment and growth factors such as TGF-ß are potentially important factors controlling ADAMTS aggrecanase activities in tendon pathology