Eddington-Limited Accretion in z~2 WISE-selected Hot, Dust-Obscured Galaxies

Hot, Dust-Obscured Galaxies, or "Hot DOGs", are a rare, dusty, hyperluminous galaxy population discovered by the WISE mission. Predominantly at redshifts 2-3, they include the most luminous known galaxies in the universe. Their high luminosities likely come from accretion onto highly obscured super massive black holes (SMBHs). We have conducted a pilot survey to measure the SMBH masses of five z~2 Hot DOGs via broad H_alpha emission lines, using Keck/MOSFIRE and Gemini/FLAMINGOS-2. We detect broad H_alpha emission in all five Hot DOGs. We find substantial corresponding SMBH masses for these Hot DOGs (~ 10^{9} M_sun), and their derived Eddington ratios are close to unity. These z~2 Hot DOGs are the most luminous AGNs at given BH masses, suggesting they are accreting at the maximum rates for their BHs. A similar property is found for known z~6 quasars. Our results are consistent with scenarios in which Hot DOGs represent a transitional, high-accretion phase between obscured and unobscured quasars. Hot DOGs may mark a special evolutionary stage before the red quasar and optical quasar phases, and they may be present at other cosmic epochs.Comment: 15 pages, 9 figures. Accepted by Ap

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.

Like ubiquitin, the small ubiquitin-related modifier (SUMO) proteins can form oligomeric chains, but the biological functions of these superstructures are not well understood. Here, we created mutant yeast strains unable to synthesize SUMO chains (smt3(allR)) and subjected them to high-content microscopic screening, synthetic genetic array (SGA) analysis, and high-density transcript profiling to perform the first global analysis of SUMO chain function. This comprehensive assessment identified 144 proteins with altered localization or intensity in smt3(allR) cells, 149 synthetic genetic interactions, and 225 mRNA transcripts (primarily consisting of stress- and nutrient-response genes) that displayed a \u3e1.5-fold increase in expression levels. This information-rich resource strongly implicates SUMO chains in the regulation of chromatin. Indeed, using several different approaches, we demonstrate that SUMO chains are required for the maintenance of normal higher-order chromatin structure and transcriptional repression of environmental stress response genes in budding yeast

Merger Negotiations in the Shadow of Judicial Appraisal

The recent surge in appraisal litigation has sparked debate over the desirability of appraisal and how this remedy should be structured. Much of this debate is based on untested assertions about appraisal\u27s ex ante effect on the structure and pricing of takeovers. Systematically investigating this effect, we find evidence that target shareholders receive higher abnormal returns as the strength of the appraisal remedy increases. We find no evidence that bidders offer a lower up- front price as a means to pay off dissenting shareholders after a sale. Further- more, threat of appraisal does not appear to limit takeover activity or impact the method of payment. Overall, our results suggest that appraisal provides an important ex ante protection for target-firm shareholders

Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer

Pancreatic cancer is a highly aggressive form of cancer with a five-year survival rate of only ten percent. Pancreatic ductal adenocarcinoma (PDAC) accounts for ninety percent of those cases. PDAC is associated with a dense stroma that confers resistance to current treatment modalities. Increasing resistance to cancer treatments poses a challenge and a need for alternative therapies. Bacterial mediated cancer therapies were proposed in the late 1800s by Dr. William Coley when he injected osteosarcoma patients with live streptococci or a fabrication of heat-killed Streptococcus pyogenes and Serratia marcescens known as Coley’s toxin. Since then, several bacteria have gained recognition for possible roles in potentiating treatment response, enhancing anti-tumor immunity, and alleviating adverse effects to standard treatment options. This review highlights key bacterial mechanisms and structures that promote anti-tumor immunity, challenges and risks associated with bacterial mediated cancer therapies, and applications and opportunities for use in PDAC management

Junior Recital: Jason Kaplan, saxophone

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Performance. Mr. Kaplan studies saxophone with Sam Skelton.https://digitalcommons.kennesaw.edu/musicprograms/1497/thumbnail.jp

Junior Recital: Muhsin Quraishi, tenor saxophone

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Performance. Mr. Quraishi studies saxophone with Sam Skelton.https://digitalcommons.kennesaw.edu/musicprograms/1943/thumbnail.jp

Junior Recital: Kwame Paige, saxophone

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Performance. Mr. Paige studies saxophone with Sam Slelton.https://digitalcommons.kennesaw.edu/musicprograms/1507/thumbnail.jp

Senior Recital: Muhsin Quraishi, saxophone, clarinet, flute

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Performance. Mr. Quraishi studies saxophone with Sam Skelton.https://digitalcommons.kennesaw.edu/musicprograms/2084/thumbnail.jp