337 research outputs found
Production and inventory management under multiple resource constraints
In this paper we present a model and solution methodology for production and inventory management problems that involve multiple resource constraints. The model formulation is quite general, allowing organizations to handle a variety of multi-item decisions such as determining order quantities, production batch sizes, number of production runs, or cycle times. Resource constraints become necessary to handle interaction among the multiple items. Common types of resource constraints include limits on raw materials, machine capacity, workforce capacity, inventory investment, storage space, or the total number of orders placed. For example, in a production environment, there may be limited workforce capacity and limits on machine capacities for manufacturing various product families. In a purchasing environment where a firm has multiple suppliers, there are often constraints for each supplier, such as the total order from each supplier cannot exceed the volume of the truck. We present efficient algorithms for solving both continuous and integer variable versions of the resource constrained production and inventory management model. The algorithms require the solution of a series of two types of subproblems: one is a nonlinear knapsack problem and the other is a nonlinear problem where the only constraints are lower and upper bounds on the variables. Computational testing of the algorithms is reported and indicates that they are effective for solving large-scale problems
Packing While Traveling: Mixed Integer Programming for a Class of Nonlinear Knapsack Problems
Packing and vehicle routing problems play an important role in the area of
supply chain management. In this paper, we introduce a non-linear knapsack
problem that occurs when packing items along a fixed route and taking into
account travel time. We investigate constrained and unconstrained versions of
the problem and show that both are NP-hard. In order to solve the problems, we
provide a pre-processing scheme as well as exact and approximate mixed integer
programming (MIP) solutions. Our experimental results show the effectiveness of
the MIP solutions and in particular point out that the approximate MIP approach
often leads to near optimal results within far less computation time than the
exact approach
Gold nanoparticles bearing an alpha-lipoic acid-based ligand shell. Synthesis, model complexes and studies concerning phosphorescent platinum(II)-functionalisation
Quality control in colorectal cancer screening: Systematic microbiological investigation of endoscopes used in the NORCCAP (Norwegian Colorectal Cancer Prevention) trial
BACKGROUND: Endoscopic colorectal cancer (CRC) screening is currently implemented in many countries. Since endoscopes cannot be sterilised, the transmission of infectious agents through endoscopes has been a matter of concern. We report on a continuous quality control programme in a large-scale randomised controlled trial on flexible sigmoidoscopy screening of an average-risk population. Continuously, throughout a two-year screening period, series of microbiological samples were taken from cleaned ready-to-use endoscopes and cultured for bacterial growth. RESULTS: 8573 endoscopies were performed during the trial period. Altogether, 178 microbiological samples (2%) were taken from the biopsy channels and surfaces from the endoscopes. One sample (0.5%) showed faecal contamination (Enterobacter cloacae), and 25 samples (14%) showed growth of environmental bacteria. CONCLUSIONS: Growth of bacteria occurs in a clinical significant number of samples from ready-to-use endoscopes. Pathogenic bacteria, however, were found only in one sample. Improvement of equipment design and cleaning procedures are desirable and continuous microbiological surveillance of endoscopes used in CRC screening is recommended
Mortality in Norway and Sweden during the COVID-19 pandemic
Background: Norway and Sweden are similar countries in terms of socioeconomics and health care. Norway implemented extensive COVID-19 measures, such as school closures and lockdowns, whereas Sweden did not. Aims: To compare mortality in Norway and Sweden, two similar countries with very different mitigation measures against COVID-19.
Methods: Using real-world data from national registries, we compared all-cause and COVID-19-related mortality rates with 95% confidence intervals (CI) per 100,000 person-weeks and mortality rate ratios (MRR) comparing the five preceding years (2015–2019) with the pandemic year (2020) in Norway and Sweden.
Results: In Norway, all-cause mortality was stable from 2015 to 2019 (mortality rate 14.6–15.1 per 100,000 person-weeks; mean mortality rate 14.9) and was lower in 2020 than from 2015 to 2019 (mortality rate 14.4; MRR 0.97; 95% CI 0.96–0.98). In Sweden, all-cause mortality was stable from 2015 to 2018 (mortality rate 17.0–17.8; mean mortality rate 17.1) and similar to that in 2020 (mortality rate 17.6), but lower in 2019 (mortality rate 16.2). Compared with the years 2015–2019, all-cause mortality in the pandemic year was 3% higher due to the lower rate in 2019 (MRR 1.03; 95% CI 1.02–1.04). Excess mortality was confined to people aged ⩾70 years in Sweden compared with previous years. The COVID-19-associated mortality rates per 100,000 person-weeks during the first wave of the pandemic were 0.3 in Norway and 2.9 in Sweden.
Conclusions: All-cause mortality in 2020 decreased in Norway and increased in Sweden compared with previous years. The observed excess deaths in Sweden during the pandemic may, in part, be explained by mortality displacement due to the low all-cause mortality in the previous year
Leadership training to improve adenoma detection rate in screening colonoscopy: A randomised trial
Objective Suboptimal adenoma detection rate (ADR) at colonoscopy is associated with increased risk of interval colorectal cancer. It is uncertain how ADR might be improved. We compared t
SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway
Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a microsimulation modelling study
OBJECTIVE: To estimate benefits and harms of different colorectal cancer screening strategies, stratified by (baseline) 15-year colorectal cancer risk. DESIGN: Microsimulation modelling study using MIcrosimulation SCreening ANalysis-Colon (MISCAN-Colon). SETTING: A parallel guideline committee (BMJ Rapid Recommendations) defined the time frame and screening interventions, including
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