Integration of Direct-Write (DW) and Ultrasonic Consolidation (UC) Technologies to Create Advanced Structures with Embedded Electrical Circuitry

In many instances conductive traces are needed in small, compact and enclosed areas. However, with traditional manufacturing techniques, embedded electrical traces or antenna arrays have not been a possibility. By integrating Direct Write and Ultrasonic Consolidation technologies, electronic circuitry, antennas and other devices can be manufactured directly into a solid metal structure and subsequently completely enclosed. This can achieve a significant reduction in mass and volume of a complex electronic system without compromising performance.Mechanical Engineerin

Evaluating Economic and Environmental Benefits of Soil and Water Conservation Measures Applied in Missouri

This study used a combination of methods to evaluate the value of Missouri's Department of Natural Resources (MODNR) conservation programs for the affected regional economies.Material in this publication is based upon work supported by the Missouri Department of Natural Resources under project ID #00009059. This publication was prepared with the support of funds from the Missouri Parks, Soil and Water Sales Tax administered by the Soil and Water Commission and the Missouri Department of Natural Resources

2007 Texas Panhandle Forage Sorghum Silage Trial

The summer of 2007 we completed our ninth year of consecutive sorghum silage variety trials conducted at the Texas Agricultural Experiment Station Bush Farm, located approximately 8 miles west of Amarillo

Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis

INTRODUCTION: Previously, secretory phospholipase A(2 )(sPLA(2)) inhibition has been used as an adjunct to conventional rheumatoid arthritis therapy in human clinical trials without significant improvement of arthritic pathology. In this study, we compared the efficacy of a potent and orally active group IIa secretory phospholipase A(2 )inhibitor (sPLA(2)I) to conventional anti-arthritic agents; infliximab, leflunomide and prednisolone, in a rat model of antigen-induced arthritis. METHODS: Initially, to establish efficacy and dose-response, rats were orally dosed with the sPLA(2)I (1 and 5 mg/kg) two days prior to arthritis induction, and then daily throughout the 14-day study period. In the second trial, rats were orally dosed with the sPLA(2)I (5 and 10 mg/kg/day) beginning two days after the induction of arthritis, at the peak of joint swelling. Separate groups of rats were also dosed with the tumour necrosis factor-alpha (TNF-α) inhibitor infliximab (single 3 mg/kg i.v. injection), leflunomide (10 mg/kg/day, oral) or prednisolone (1 mg/kg/day, oral) at this same time point and used as comparative treatments. RESULTS: In the pathology prevention trial, both 1 and 5 mg/kg dose groups of sPLA(2)I demonstrated a significant reduction in joint swelling and gait disturbances; however, only the higher 5 mg/kg dose resulted in significantly reduced histopathology scores. In the post-induction trial, rats dosed with sPLA(2)I showed a significant improvement in joint swelling and gait scoring, whereas none of the conventional therapeutics achieved a significant decrease in both of these two disease markers. Histopathological scoring at the end-point of the study demonstrated significantly reduced median scores in rats treated with 10 mg/kg sPLA(2)I and leflunomide. CONCLUSIONS: The results from this study suggest a pathogenic role for sPLA(2 )enzymes in this model of arthritis in rats, and the potential clinical utility of sPLA(2 )inhibition as a safer, and more effective, alternative to conventional anti-arthritic therapeutics

Genetic origins of social networks in rhesus macaques

This is the final version of the article. Available from the publisher via the DOI in this record.Sociality is believed to have evolved as a strategy for animals to cope with their environments. Yet the genetic basis of sociality remains unclear. Here we provide evidence that social network tendencies are heritable in a gregarious primate. The tendency for rhesus macaques, Macaca mulatta, to be tied affiliatively to others via connections mediated by their social partners - analogous to friends of friends in people - demonstrated additive genetic variance. Affiliative tendencies were predicted by genetic variation at two loci involved in serotonergic signalling, although this result did not withstand correction for multiple tests. Aggressive tendencies were also heritable and were related to reproductive output, a fitness proxy. Our findings suggest that, like humans, the skills and temperaments that shape the formation of multi-agent relationships have a genetic basis in nonhuman primates, and, as such, begin to fill the gaps in our understanding of the genetic basis of sociality.We thank Bonn Aure, Jacqueline Buhl, Monica Carlson, Matthew McConnell, Elizabeth Maldonado, David Paulsen, Cecilia Penedo & the Caribbean Primate Research Center (CPRC) for assistance, and Roger Mundry for the use of PSAM software. The authors were supported by NIMH grant R01-MH089484, an Incubator Award from the Duke Institute for Brain Sciences, and a Duke Center for Interdisciplinary Decision Sciences Fellowship to LJNB. The CPRC is supported by grant 8-P40 OD012217-25 from the National Center for Research Resources (NCRR) and the Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health

Genetic influences on social attention in free-ranging rhesus macaques

An ethological approach to attention predicts that organisms orient preferentially to valuable sources of information in the environment. For many gregarious species, orienting to other individuals provides valuable social information but competes with food acquisition, water consumption and predator avoidance. Individual variation in vigilance behaviour in humans spans a continuum from inattentive to pathological levels of interest in others. To assess the comparative biology of this behavioural variation, we probed vigilance rates in free-ranging macaques during water drinking, a behaviour incompatible with the gaze and postural demands of vigilance. Males were significantly more vigilant than females. Moreover, vigilance showed a clear genetic component, with an estimated heritability of 12%. Monkeys carrying a relatively infrequent ‘long’ allele of TPH2, a regulatory gene that influences serotonin production in the brain, were significantly less vigilant compared to monkeys that did not carry the allele. These findings resonate with the hypothesis that the serotonin pathway regulates vigilance in primates and by extension provoke the idea that individual variation in vigilance and its underlying biology may be adaptive rather than pathological

Cosmic flow from 2MASS redshift survey: The origin of CMB dipole and implications for LCDM cosmology

We generate the peculiar velocity field for the 2MASS Redshift Survey (2MRS) catalog using an orbit-reconstruction algorithm. The reconstructed velocities of individual objects in 2MRS are well-correlated with the peculiar velocities obtained from high-precision observed distances within 3,000 km/s. We estimate the mean matter density to be 0.31 +/- 0.05 by comparing observed to reconstructed velocities in this volume. The reconstructed motion of the Local Group in the rest frame established by distances within 3,000 km/s agrees with the observed motion and is generated by fluctuations within this volume, in agreement with observations. Then, we reconstruct the velocity field of 2MRS in successively larger radii, to study the problem of convergence towards the CMB dipole. We find that less than half of the amplitude of the CMB dipole is generated within a volume enclosing the Hydra-Centaurus-Norma supercluster at around 40 Mpc/h. Although most of the amplitude of the CMB dipole seems to be recovered by 120 Mpc/h, the direction does not agree and hence we observe no convergence up to this scale. We develop a statistical model which allows us to estimate cosmological para meters from the reconstructed growth of convergence of the velocity of the Local Group towards the CMB dipole motion. For scales up to 60 Mpc/h, assuming a Local Group velocity of 627 km/s, we estimate Omega_m h^2 = 0.11 +/- 0.06 and sigma_8=0.9 +/- 0.4, in agreement with WMAP5 measurements at the 1-sigma level. However, for scales up to 100 Mpc/h, we obtain Omega_m h^2 = 0.08 +/- 0.03 and sigma_8=1.0 +/- 0.4, which agrees at the 1 to 2-sigma level with WMAP5 results. (abridged)Comment: 19 pages, 9 figures, 4 tables, accepted by ApJ. No modifications since last version. The modeled velocity field is available at first author's webpage: http://guilhem.lavaux.free.fr/wordpress/?page_id=28

Outward Migration of Jupiter and Saturn in Evolved Gaseous Disks

The outward migration of a pair of resonant-orbit planets, driven by tidal interactions with a gas-dominated disk, is studied in the context of evolved solar nebula models. The planets' masses, M1 and M2, correspond to those of Jupiter and Saturn. Hydrodynamical calculations in two and three dimensions are used to quantify the migration rates and analyze the conditions under which the outward migration mechanism may operate. The planets are taken to be fully formed after 1e6 and before 3e6 years. The orbital evolution of the planets in an evolving disk is then calculated until the disk's gas is completely dissipated. Orbital locking in the 3:2 mean motion resonance may lead to outward migration under appropriate conditions of disk viscosity and temperature. However, resonance locking does not necessarily result in outward migration. This is the case, for example, if convergent migration leads to locking in the 2:1 mean motion resonance, as post-formation disk conditions seem to suggest. Accretion of gas on the planets may deactivate the outward migration mechanism by raising the mass ratio M2/M1 and/or by reducing the accretion rate toward the star, hence depleting the inner disk. For migrating planets locked in the 3:2 mean motion resonance, there are stalling radii that depend on disk viscosity and on stellar irradiation, when it determines the disk's thermal balance. Planets locked in the 3:2 orbital resonance that start moving outward from within 1-2 AU may reach beyond 5 AU only under favorable conditions. However, within the explored space of disk parameters, only a small fraction - less than a few per cent - of the models predict that the interior planet reaches beyond 4 AU.Comment: 24 pages, 22 figures. To appear in The Astrophysical Journal. Updated with corrections added in proo

Systematic Analysis of Whole Exome Sequencing Determines RET G691S Polymorphism as Germline Variant in Melanoma

Abstract The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by glial cell derived neutrotrophic factor (GDNF). Previous studies have found that a single nucleotide polymorphism (SNP), RETp (G691S), in the juxtamembrane domain enhances the signaling pathway and promotes tumor growth by GDNF in pancreatic and thyroid cancer in addition to melanoma. It is uncertain however whether this SNP is a germline variant or somatic mutation. A prior study reported that the RETp variant was a germline SNP in desmoplastic and non-desmoplastic melanomas. In the present study, we examined both melanoma tissue samples and matching peripheral blood DNA to determine if RETp was 1) a germline or somatic variant, 2) more frequent in certain melanoma subtypes, and 3) frequency in brain metastasis. We examined the peripheral blood of 197 melanoma patients whom had at least one matched tumor, and 42 patients with brain metastasis. RETp was present as a germline SNP in 33% of patients. There were no significant differences in RETp frequency among the different melanoma subtypes, and RETp was not correlated with brain metastasis