383 research outputs found

    Who Makes the Call on Goodwill Impairment Charges: CEOs or CFOs?

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    Goodwill impairment involves subjective estimations and a high degree of managerial discretion. However, it remains unclear whether CEOs or CFOs have more influence on goodwill valuation. We address the question by investigating the relation between executives’ equity incentives and goodwill impairments. We find that firms with higher CEO or CFO equity incentives report lower annual goodwill impairments. Interestingly, the negative relation is stronger for CFO equity incentives. Further, we conjecture and find that the relative influence of CEOs and CFOs on goodwill impairments differs in a setting involving executive turnovers. Specifically, we find that a new CFO has no significant effect on impairment decisions. In contrast, a new CEO is associated with a higher probability of recording a large goodwill impairment, presumably to engage in “big bath” accounting. Taken together, our results suggest that, while incumbent CFOs are in charge of routine review of goodwill valuation, new CEOs have the final authority on large-impairment decisions

    Climate-driven Shifts in Quantity and Seasonality of River Discharge over the past 1000 Years from the Hydrographic Apex of North America

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    Runoff generated from high elevations is the primary source of freshwater for western North America, yet this critical resource is managed on the basis of short instrumental records that capture an insufficient range of climatic conditions. Here we probe the effects of climate change over the past ~1000 years on river discharge in the upper Mackenzie River system based on paleoenvironmental information from the Peace-Athabasca Delta. The delta landscape responds to hydroclimatic changes with marked variability, while Lake Athabasca level appears to directly monitor overall water availability. The latter fluctuated systematically over the past millennium, with the highest levels occurring in concert with maximum glacier extent during the Little Ice Age, and the lowest during the 11th century, prior to medieval glacier expansion. Recent climate-driven hydrological change appears to be on a trajectory to even lower levels as high-elevation snow and glacier meltwater contributions both continue to decline

    Comparison of Neuromuscular Injuries to the Surgeon during Hand-Assisted and Standard Laparoscopic Urologic Surgery

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    Background and Purpose: Hand-assisted procedures have assumed a greater role in the practice of many laparoscopists. We surveyed major laparoscopy program directors to compare the incidence and location of neuromuscular injury to the surgeon during hand-assisted laparoscopic (HAL) and standard laparoscopic (SL) surgery. Materials and Methods: A questionnaire on neuromuscular injuries was e-mailed to 42 laparoscopic program directors. Respondents were instructed to report only injuries or pain associated with laparoscopic surgery when they were the primary responsible surgeon and not during open or endoscopic procedures. Results: Surveys were returned from 23 attending laparoscopic surgeons and 2 laparoscopic fellows. Surgeons reported an average of 3.9 HAL and 6.3 SL cases per month as the primary surgeon. The HAL was completed with the GelPort, LapDisk, Omniport, or a combination of devices 55%, 22%, 5%, and 14%, respectively, of the time. Comparing HAL with SL, there was significantly more hand/wrist, forearm, and shoulder pain/injuries associated with HAL (P < 0.004). There was significantly more neck pain associated with SL than HAL (P < 0.003), but no significant difference in lower-back pain (P = 0.40). Comparing the two most commonly used hand-assist devices (GelPort and LapDisk), the LapDisk demonstrated significantly more hand/wrist pain or injury (P = 0.001). Conclusion: Hand-assisted laparoscopy is associated with more frequent neuromuscular strain to the upper extremity than SL, but SL surgeons experience more neck pain or injury. Surgeon discomfort is also dependent on the type of hand-assist device. The long-term consequences of physical strain on the laparoscopic surgeon are unknown currently, but measures to minimize neuromuscular strain should be considered.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63117/1/end.2005.19.377.pd

    Combining EEG and Eye Tracking: Using Fixation-Locked Potentials in Visual Search

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    Visual search is a complex task that involves many neural pathways to identify relevant areas of interest within a scene. Humans remain a critical component in visual search tasks, as they can effectively perceive anomalies within complex scenes. However, this task can be challenging, particularly under time pressure. In order to improve visual search training and performance, an objective, process-based measure is needed. Eye tracking technology can be used to drive real-time parsing of EEG recordings, providing an indication of the analysis process. In the current study, eye fixations were used to generate ERPs during a visual search task. Clear differences were observed following performance, suggesting that neurophysiological signatures could be developed to prevent errors in visual search tasks

    Elementary Statistics (GHC)

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    This Grants Collection for Elementary Statistics was created under a Round Eleven ALG Textbook Transformation Grant. Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/mathematics-collections/1039/thumbnail.jp

    ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brain

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    <p>Abstract</p> <p>Background</p> <p>ZnT3 is a membrane Zn<sup>2+ </sup>transporter that is responsible for concentrating Zn<sup>2+ </sup>into neuronal presynaptic vesicles. Zn<sup>2+ </sup>homeostasis in the brain is relevant to Alzheimer's disease (AD) because Zn<sup>2+ </sup>released during neurotransmission may bind to Aβ peptides, accelerating the assembly of Aβ into oligomers which have been shown to impair synaptic function.</p> <p>Results</p> <p>We quantified ZnT3 mRNA levels in Braak-staged human post mortem (pm) brain tissue from medial temporal gyrus, superior occipital gyrus, superior parietal gyrus, superior frontal gyrus and cerebellum from individuals with AD (n = 28), and matched controls (n = 5) using quantitative real-time PCR. ZnT3 mRNA levels were significantly decreased in all four cortical regions examined in the AD patients, to 45-60% of control levels. This reduction was already apparent at Braak stage 4 in most cortical regions examined. Quantification of neuronal and glial-specific markers in the same samples (neuron-specific enolase, NSE; and glial fibrillary acidic protein, GFAP) indicated that loss of cortical ZnT3 expression was more pronounced, and occurred prior to, significant loss of NSE expression in the tissue. Significant increases in cortical GFAP expression were apparent as the disease progressed. No gene expression changes were observed in the cerebellum, which is relatively spared of AD neuropathology.</p> <p>Conclusions</p> <p>This first study to quantify ZnT3 mRNA levels in human pm brain tissue from individuals with AD and controls has revealed a significant loss of ZnT3 expression in cortical regions, suggesting that neuronal cells in particular show reduced expression of ZnT3 mRNA in the disease. This suggests that altered neuronal Zn<sup>2+ </sup>handling may be an early event in AD pathogenesis.</p

    Space object identification using phase-diverse speckle

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    Space-object identification from ground-based telescopes is challenging because of the degradation in resolution arising from atmospheric turbulence. Phase-diverse speckle is a novel post-detection correction method that can be used to overcome turbulence-induced aberrations for telescopes with or without adaptive optics. We present a simulation study of phase-diverse speckle satellite reconstructions for the Air Force Maui Optical station 1.6-meter telescope. For a given turbulence strength, satellite reconstruction fidelity is evaluated as a function of quality and quantity of data. The credibility of this study is enhanced by reconstructions from actual compensated data collected with the 1.5-meter telescope at the Starfire Optical Range. Consistent details observed across a time series of reconstructions from a portion of a satellite pass enhance the authenticity of these features. We conclude that phase-diverse speckle can restore fine-resolution features not apparent in the raw aberrated images of space objects

    Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue

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    <p>Abstract</p> <p>Background</p> <p>Studies of gene expression in post mortem human brain can contribute to understanding of the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Quantitative real-time PCR (RT qPCR) is often used to analyse gene expression. The validity of results obtained using RT qPCR is reliant on accurate data normalization. Reference genes are generally used to normalize RT qPCR data. Given that expression of some commonly used reference genes is altered in certain conditions, this study aimed to establish which reference genes were stably expressed in post mortem brain tissue from individuals with AD, PD or DLB.</p> <p>Results</p> <p>The present study investigated the expression stability of 8 candidate reference genes, (ubiquitin C [UBC], tyrosine-3-monooxygenase [YWHAZ], RNA polymerase II polypeptide [RP II], hydroxymethylbilane synthase [HMBS], TATA box binding protein [TBP], β-2-microglobulin [B2M], glyceraldehyde-3-phosphate dehydrogenase [GAPDH], and succinate dehydrogenase complex-subunit A, [SDHA]) in cerebellum and medial temporal gyrus of 6 AD, 6 PD, 6 DLB subjects, along with 5 matched controls using RT qPCR (TaqMan<sup>® </sup>Gene Expression Assays). Gene expression stability was analysed using geNorm to rank the candidate genes in order of decreasing stability in each disease group. The optimal number of genes recommended for accurate data normalization in each disease state was determined by pairwise variation analysis.</p> <p>Conclusion</p> <p>This study identified validated sets of mRNAs which would be appropriate for the normalization of RT qPCR data when studying gene expression in brain tissue of AD, PD, DLB and control subjects.</p

    KSU Chorale, Women\u27s Choir and special guest Hillgrove High School Chamber Choir, Fall Choral Concert

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    KSU School of Music presents Fall Choral Concert featuring KSU Chorale, KSU Women\u27s Choir and special guest, Hillgrove High School Chamber Choir.https://digitalcommons.kennesaw.edu/musicprograms/1278/thumbnail.jp
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