Patient safety indicators for England from hospital administrative data: case-control analysis and comparison with US data

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The Healthcare Commission received a small grant from the Health and Social Care Information Centre to support the initial recoding work

Influence of PWM on the proximity loss in permanent magnet brushless AC machines

The winding copper loss can be significantly increased due to skin and proximity eddy current effects. The skin and proximity losses due to fundamental frequency current has been investigated in literature, but the influence of PWM on the skin and proximity losses has not been reported. In this paper, 2-D finite element method is employed to analyze the skin and proximity losses in a permanent magnet brushless AC machine, in which significant proximity loss exists due to high frequency current ripples induced by the PWM, as confirmed by both theoretical calculation and experiment. The analyses should be generally applicable to other machines

Bringing reality to the classroom: Exercises in intertextuality

The ability to handle intertextual relations in email is an important component of workplace writing competence that is, for the most part, overlooked in business English classes because of a tendency to treat emails in classroom contexts as independent texts. This study reports on a series of email assignments that required students to read and process a collection of texts before composing emails themselves, with the aim of examining how students dealt with the demands made by the intertextual nature of workplace writing. The findings suggest that the management of multiple texts and their intertextual relations poses considerable challenges for student writers, specifically relating to the amount of information to include, the degree of explicitness needed in referring to other texts, and the management of the dialogue and writer-reader relationship. The study concludes that there is a need to demonstrate to students the centrality of intertextuality and the ways in which it contributes to the coherence of workplace communication. Students need to understand, too, that managing intertextuality is not simply a question of textual manipulation, but of understanding the communicative context and of considering how they want their relationship with the reader to develop

Reintroducing San Joaquin kit fox (Vulpes macrotis mutica) to vacant or restored lands: identifying optimal source populations and candidate foxes

Endangered San Joaquin kit foxes (Vulpes macrotis mutica) currently persist as a meta- population in central California consisting of 3 core and several satellite populations. Many of these populations are small and the meta-population is highly fragmented, which increases extinction risk. Translocation is a potential strategy for increasing the number of populations. Various factors would need to be considered when selecting source populations and candidate foxes for translocation. One such factor is behavioral attributes of individual foxes, as reflected by level of boldness, particularly in response to novel resources and potential threats. We compared behavioral attributes between and within populations of kit foxes in urban and non-urban habitats, and also examined the relationship of these attributes to survival and fitness. The overall goal of this project was to identify optimal source populations and individual foxes for relocation efforts, and in particular to determine whether urban foxes could be used in such efforts

Vaccinations, infections and antibacterials in the first grass pollen season of life and risk of later hayfever

Published source: Bremner, S. A., Carey, I. M., DeWilde, S., Richards, N., Maier, W. C., Hilton, S. R., Strachan, D. P. and Cook, D. G. (2007), Vaccinations, infections and antibacterials in the first grass pollen season of life and risk of later hayfever. Clinical & Experimental Allergy, 37: 512–517. doi: 10.1111/j.1365-2222.2007.02697.

Single-inhaler fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol plus umeclidinium using two inhalers for chronic obstructive pulmonary disease: A randomized non-inferiority study

Background: Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patients with chronic obstructive pulmonary disease (COPD). We evaluated the non-inferiority of single-inhaler FF/UMEC/VI versus FF/VI + UMEC using two inhalers. Methods: Eligible patients with COPD (aged ≥40 years; ≥1 moderate/severe exacerbation in the 12 months before screening) were randomized (1:1; stratified by the number of long-acting bronchodilators [0, 1 or 2] per day during run-in) to receive 24-week FF/UMEC/VI 100/62.5/25 μg and placebo or FF/VI 100/25 μg + UMEC 62.5 μg; all treatments/placebo were delivered using the ELLIPTA inhaler once-daily in the morning. Primary endpoint: change from baseline in trough forced expiratory volume in 1 s (FEV1) at Week 24. The non-inferiority margin for the lower 95% confidence limit was set at − 50 mL. Results: A total of 1055 patients (844 [80%] of whom were enrolled on combination maintenance therapy) were randomized to receive FF/UMEC/VI (n = 527) or FF/VI + UMEC (n = 528). Mean change from baseline in trough FEV1 at Week 24 was 113 mL (95% CI 91, 135) for FF/UMEC/VI and 95 mL (95% CI 72, 117) for FF/VI + UMEC; the between-treatment difference of 18 mL (95% CI -13, 50) confirmed FF/UMEC/VI’s was considered non-inferior to FF/ VI + UMEC. At Week 24, the proportion of responders based on St George’s Respiratory Questionnaire Total score was 50% (FF/UMEC/VI) and 51% (FF/VI + UMEC); the proportion of responders based on the Transitional Dyspnea Index focal score was similar (56% both groups). A similar proportion of patients experienced a moderate/severe exacerbation in the FF/UMEC/VI (24%) and FF/VI + UMEC (27%) groups; the hazard ratio for time to first moderate/ severe exacerbation with FF/UMEC/VI versus FF/VI + UMEC was 0.87 (95% CI 0.68, 1.12). The incidence of adverse events was comparable in both groups (48%); the incidence of serious adverse events was 10% (FF/UMEC/VI) and 11% (FF/VI + UMEC). Conclusions: Single-inhaler triple therapy (FF/UMEC/VI) is non-inferior to two inhalers (FF/VI + UMEC) on trough FEV1 change from baseline at 24 weeks. Results were similar on all other measures of efficacy, health-related quality of life, and safety. Trial registration: GSK study CTT200812; ClinicalTrials.gov NCT02729051 (submitted 31 March 2016)

Coping with Persistent Pain, Effectiveness Research into Self-management (COPERS): statistical analysis plan for a randomised controlled trial

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated