Mechanisms of Action in a Behavioral Weight-Management Program: Latent Growth Curve Analysis.

BACKGROUND: A greater understanding of the mechanisms of action of weight-management interventions is needed to inform the design of effective interventions. PURPOSE: To investigate whether dietary restraint, habit strength, or diet self-regulation mediated the impact of a behavioral weight-management intervention on weight loss and weight loss maintenance. METHODS: Latent growth curve analysis (LGCA) was conducted on trial data in which adults (N = 1,267) with a body mass index (BMI) ≥28 kg/m2 were randomized to either a brief intervention (booklet on losing weight), a 12 week weight-management program or the same program for 52 weeks. LGCA estimated the trajectory of the variables over four time points (baseline and 3, 12 and 24 months) to assess whether potential mechanisms of action mediated the impact of the weight-management program on BMI. RESULTS: Participants randomized to the 12 and 52 week programs had a significantly greater decrease in BMI than the brief intervention. This direct effect became nonsignificant when dietary restraint, habit strength, and autonomous diet self-regulation were controlled for. The total indirect effect was significant for both the 12 (estimate = -1.33, standard error [SE] = 0.41, p = .001) and 52 week (estimate = -2.13, SE = 0.52, p < .001) program. Only the individual indirect effect for dietary restraint was significant for the 12 week intervention, whereas all three indirect effects were significant for the 52 week intervention. CONCLUSIONS: Behavior change techniques that target dietary restraint, habit strength, and autonomous diet self-regulation should be considered when designing weight loss and weight loss maintenance interventions. Longer interventions may need to target both deliberative and automatic control processes to support successful weight management

Orbital-scale climate variability in Arabia as a potential motor for human dispersals

The Arabian Peninsula is situated at an important crossroads for the movement of Pleistocene human populations out of, and into, Africa. Although the timings, routes and frequencies of such dispersals have not yet been confirmed by genetic, fossil or archaeological evidence, expansion into Arabia would have been facilitated by humid periods driven by incursions of monsoon rainfall, potentially from both Indian Ocean and African monsoon systems. Here we synthesise terrestrial and marine core palaeoclimatic data in order to establish the spatial and temporal variability of humid periods in Arabia between late Marine Isotope Stage (MIS) 7 and 3. Incursions of monsoon rainfall occurred during periods of insolation maxima at ca. 200–190, 170, 155, 130–120, 105–95, 85–75 and 60–55 ka, providing multiple ‘windows’ of favourable climatic conditions that could have facilitated demographic expansion through Arabia. Strong summer monsoons are generally associated with mid-high latitude interglacials, however, enhanced monsoon convection also brought rainfall into Arabia during global glacial phases, possibly due to a strengthened winter monsoon and a greater influence of southern hemispheric temperature changes. Key periods for dispersal into northern regions of Arabia correspond with the synchronous intensification of both eastern Mediterranean and monsoon rainfall systems at insolation maxima during MIS 7 and MIS 5, which may have facilitated demographic connectivity between the Levant and the Arabian interior. Environmental conditions throughout southern and southeast regions were also favourable to expansion during these times, although strong monsoons in these regions during MIS 6 and MIS 3 suggest further opportunities for demographic expansion and exchange. Terrestrial and marine evidence show that during early MIS 3 (ca. 60–50 ka), a strengthened monsoon led to the activation of interior drainage systems and increased productivity in coastal zones, indicating that favourable environmental conditions existed along both coastal and interior routes at that time

Separation of rhodium from iridium through synergistic solvent extraction

There are currently few effective processes for the solvent extraction of rhodium from hydrochloric acid streams, and none that allow rhodium to be selectively extracted over iridium. Realizing this goal could allow rhodium to be recovered earlier in a typical platinum group metal (PGM) refining flowsheet and reduce the environmental impact of PGM refining. In this work, we show that a synergistic combination of a tert-alkyl primary amine LA and various inner-sphere ligands L can be used to recover rhodium via the complex [RhCl5L].HLA2. Although we show that rhodium is extracted by several extractant combinations, it is only readily stripped from the amine/amide synergistic mixture. As this extraction relies on the inner-sphere coordination of the amide to the metal, this process also demonstrates a route to obtain preferential extraction of rhodium over more inert iridium chloridometalates under industrially relevant conditions.</p

Wild Food:Plants, Fish and Small Animals on the Menu for Early Holocene Populations at al-Khiday, Central Sudan

Al Khiday, located on the bank of the White Nile in Sudan, offers an exceptionally preserved stratigraphic sequence, providing a unique opportunity to use organic residue analysis to investigate diet and subsistence over the full course of the Khartoum Mesolithic together with possible continuity or change into the Early Neolithic, a period of nearly 3000 years (8900-6000 cal BP). Whilst the vast and diverse Mesolithic fish assemblage indicates a strong reliance on products from aquatic habitats, floodplains, vegetated marshes and open water, results from the lipid residue analysis suggest that the fish were not cooked in the pots, likely being consumed in other ways. Rather, pots were more specialised in processing plants, wild grasses, leafy plants and sedges, confirmed by experimental analysis, and for the first time, providing direct chemical evidence for plant exploitation in the Khartoum Mesolithic. Non-ruminant fauna, such as warthog and low lipid-yielding reptiles such as Adanson’s mud turtle and Nile monitor lizard, which were found in significant numbers at al-Khiday, were also cooked in pots. There is little evidence for the processing of wild ruminants in the pots, suggesting either that ruminant species were not routinely hunted, or, that large wild fauna may have been cooked in different ways, possibly grilled over fires. These data suggest sophisticated economic strategies by sedentary people likely exploiting their ecological niche to the fullest. Pottery use changes considerably in the Early Neolithic, with ruminant products being more routinely processed in pots, and while the exploitation of domesticates cannot be confirmed by a small faunal assemblage, some dairying does take place. In summary, our results provide valuable information on Early and Middle Holocene lifeways in central Sudan

Regulating services

No abstract available

Defining paleoclimatic routes and opportunities for hominin dispersals across Iran

Fossil and archaeological evidence indicates that hominin dispersals into Southwest Asia occurred throughout the Pleistocene, including the expansion of Homo sapiens populations out of Africa. While there is evidence for hominin occupations in the Pleistocene in Iran, as evidenced by the presence of Lower to Upper Paleolithic archaeological sites, the extent to which humid periods facilitated population expansions into western Asia has remained unclear. To test the role of humid periods on hominin dispersals here we assess Paleolithic site distributions and paleoenvironmental records across Iran. We developed the first spatially comprehensive, high-resolution paleohydrological model for Iran in order to assess water availability and its influence on hominin dispersals. We highlight environmentally mediated routes which likely played a key role in Late Pleistocene hominin dispersals, including the expansion of H. sapiens and Neanderthals eastwards into Asia. Our combined analyses indicate that, during MIS 5, there were opportunities for hominins to traverse a northern route through the Alborz and Kopet Dagh Mountains and the Dasht-I Kavir desert owing to the presence of activated fresh water sources. We recognize a new southern route along the Zagros Mountains and extending eastwards towards Pakistan and Afghanistan. We find evidence for a potential northern route during MIS 3, which would have permitted hominin movements and species interactions in Southwest Asia. Between humid periods, these interconnections would have waned, isolating populations in the Zagros and Alborz Mountains, where hominins may have continued to have had access to water

Bringing numerous methods for expression and promoter analysis to a public cloud computing service

Every year, a large number of novel algorithms are introduced to the scientific community for a myriad of applications, but using these across different research groups is often troublesome, due to suboptimal implementations and specific dependency requirements. This does not have to be the case, as public cloud computing services can easily house tractable implementations within self-contained dependency environments, making the methods easily accessible to a wider public. We have taken 14 popular methods, the majority related to expression data or promoter analysis, developed these up to a good implementation standard and housed the tools in isolated Docker containers which we integrated into the CyVerse Discovery Environment, making these easily usable for a wide community as part of the CyVerse UK project

Taphonomic and zooarchaeological investigations at the middle Pleistocene site of Ti's al Ghadah, western Nefud Desert, Saudi Arabia

In recent years, the Arabian Peninsula has emerged as a key region for elucidating hominin and faunal evolution and dispersals between Africa and Eurasia. Central to this research is the middle Pleistocene site of Ti's al Ghadah (TAG) which has yielded a diverse and abundant fossil faunal assemblage and the earliest chronometrically dated evidence for hominins in this part of the world. Here, we present the first detailed taphonomic study of the large Unit 5 fossil assemblage from the site. We aim to assess which actor/s were responsible for the accumulation of the assemblage and evaluate evidence that might be consistent with the accumulation of fauna by hominins. We also describe, for the first time, fossils and lithic artefacts from stratigraphic horizons not previously considered, providing taphonomic insights into their accumulation. The taphonomic work shows that the Unit 5 faunal assemblage was accumulated by ambush predators, likely large felids and hominins, in a lake side environment, and that carcasses were subsequently scavenged by more durophagus carnivores such as hyenas and canids. Less can be reliably said regarding the newly described fossil assemblages given their poor preservation and significant wind abrasion, but large carnivores again appear to have played a role, and hominins probably played a role in the accumulation of at least one of these. This study provides the first detail insights into the interplay between hominins, carnivores, and herbivores in Arabia, and suggests that watering holes have been a focus on the Arabian landscape for resources since the middle Pleistocene

Design and testing of a national pollinator and pollination monitoring framework

Final summary report to the Department for Environment, Food and Rural Affairs (Defra), Scottish Government and Welsh Government: Project WC1101

Pollinator monitoring more than pays for itself

1. Resilient pollination services depend on sufficient abundance of pollinating insects over time. Currently, however, most knowledge about the status and trends of pollinators is based on changes in pollinator species richness and distribution only. 2. Systematic, long‐term monitoring of pollinators is urgently needed to provide baseline information on their status, to identify the drivers of declines and to inform suitable response measures. 3. Power analysis was used to determine the number of sites required to detect a 30% change in pollinator populations over 10 years. We then evaluated the full economic costs of implementing four national monitoring schemes in the UK: (a) professional pollinator monitoring, (b) professional pollination service monitoring, (c) volunteer collected pan traps and (d) volunteer focal floral observations. These costs were compared to (a) the costs of implementing separate, expert‐designed research and monitoring networks and (b) the economic benefits of pollination services threatened by pollinator loss. 4. Estimated scheme costs ranged from £6,159/year for a 75‐site volunteer focal flower observation scheme to £2.7 M/year for an 800‐site professional pollination service monitoring network. The estimated research costs saved using the site network as research infrastructure range from £1.46–4.17 M/year. The economic value of UK crop yield lost following a 30% decline in pollinators was estimated at ~£188 M/year. 5. Synthesis and applications. We evaluated the full costs of running pollinator monitoring schemes against the economic benefits to research and society they provide. The annual costs of monitoring are <0.02% of the economic value of pollination services that would be lost after a 30% decline in pollination services. Furthermore, by providing high‐quality scientific data, monitoring schemes would save at least £1.5 on data collection per £1 spent. Our findings demonstrate that long‐term systematic monitoring can be a cost‐effective tool for both answering key research questions and setting action points for policymakers. Careful consideration must be given to scheme design, the logistics of national‐scale implementation and resulting data quality when selecting the most appropriate combination of surveyors, methods and site networks to deliver a successful scheme