A Regional Approach to Drinking Water Management: NL-BC Comparative Water Systems Study

Water is recognized as a basic human right, a critical service, a fundamental for sustainability, and a building block for resilience. In Canada, rural areas face unique challenges when it comes to drinking water management (e.g., multi-use watersheds, low population density, lack of economies of scale). Not only are these challenges in the present, but these unique issues are also important in terms of future adaptation and can act as barriers to future community and regional resilience. Research indicates that while managing drinking water is a critical issue for rural Canada, current management approaches appear to be ill equipped to address this issue, particularly in the context of regional resilience. In this report we propose a new approach to managing drinking water, using the regional scale and incorporating best practices related to regional development, new regionalism, regional resilience, water management, and sustainable infrastructure

Does Process Matter in Military Sentencing? A Study of the Trial Penalty in Air Force Courts-Martial

Prior sentencing research has largely ignored the military justice system even though over two million people are subject to its jurisdiction. Studying the military justice system advances knowledge of the military population and offers an opportunity to explore criminal justice issues and theoretical perspectives in a different legal system that includes jury sentencing. The present study applies organizational efficiency, uncertainty avoidance, and court community perspectives to investigate whether military offenders who assert their Sixth Amendment right to a jury trial are penalized with harsher sentences than offenders who plead guilty. Using Air Force court-martial data from 2005 and 2006, the results of the study found no support for a trial penalty effect and also found that juries are less likely to impose severe types of punishment compared to judges. The study offers possible explanations for these findings and discusses implications for public policy, theory, and the direction for future research

Small hydro: a tool for sustainable community development in rural Canada

An examination of the use of small hydro as a tool for sustainable community development, this dissertation combines research from the fields of community development, sustainability, and renewable energy development. Historically, community owned small hydro has been used for the benefit of local communities, initially through the provision of services and later through the generation of revenue. Current literature suggests that there is also a strong link between community energy and sustainability. Through an examination of four community-owned small hydro case studies, this research employed semi-structured interviews and sustainable development indicators to examine how each of the communities developed and used small hydro for the betterment of the community. This examination provided the basis for an evaluation of the overall impact of small hydro on community sustainability. Additionally, this dissertation discusses the connection, or lack thereof, between sustainability, energy use, energy generation, and the surrounding institutions (i.e. the energy disconnect)

The Determinants of Court-Martial Decisions: An Empirical Investigation into the Air Force's Criminal Court Process

In spite of many similarities with civilian criminal courts, public debate continues about further "civilianizing" the modern court-martial process to enhance legitimacy and reduce unwarranted disparities. Unfortunately, researchers and policymakers know very little about the determinants of court-martial decisions and the influence of military culture in the process. The current study begins to address this void in the empirical literature and informs contemporary reform discussions with its examination of the legal and extra-legal factors for court-martial decision outcomes at different stages of the process. With an extension of modern courts and sentencing theoretical perspectives, this study utilized multi-level modeling techniques with Air Force court-martial data from 2005-2008 to investigate the effects of individual-level factors as well as inter-court community and inter-judge disparities. The results revealed a number of findings that were contrary to civilian court research and theoretical expectations particularly for military-specific outcomes. Additionally, the analysis detected some evidence of disparities consistent with the influence of traditional military culture for decisions earlier in the court-martial process. The implications for the current public policy debate, courts and sentencing theoretical development, and future research are discussed

Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.

We previously identified FOXL2 as a critical component in FSHβ gene transcription. Here, we show that mice deficient in FOXL2 have lower levels of gonadotropin gene expression and fewer LH- and FSH-containing cells, but the same level of other pituitary hormones compared to wild-type littermates, highlighting a role of FOXL2 in the pituitary gonadotrope. Further, we investigate the function of FOXL2 in the gonadotrope cell and determine which domains of the FOXL2 protein are necessary for induction of FSHβ transcription. There is a stronger induction of FSHβ reporter transcription by truncated FOXL2 proteins, but no induction with the mutant lacking the forkhead domain. Specifically, FOXL2 plays a role in activin induction of FSHβ, functioning in concert with activin-induced SMAD proteins. Activin acts through multiple promoter elements to induce FSHβ expression, some of which bind FOXL2. Each of these FOXL2-binding sites is either juxtaposed or overlapping with a SMAD-binding element. We determined that FOXL2 and SMAD4 proteins form a higher order complex on the most proximal FOXL2 site. Surprisingly, two other sites important for activin induction bind neither SMADs nor FOXL2, suggesting additional factors at work. Furthermore, we show that FOXL2 plays a role in synergistic induction of FSHβ by GnRH and activin through interactions with the cJUN component of the AP1 complex that is necessary for GnRH responsiveness. Collectively, our results demonstrate the necessity of FOXL2 for proper FSH production in mice and implicate FOXL2 in integration of transcription factors at the level of the FSHβ promoter

Biomarkers of aging associated with past treatments in breast cancer survivors.

Radiation and chemotherapy are effective treatments for cancer, but are also toxic to healthy cells. Little is known about whether prior exposure to these treatments is related to markers of cellular aging years later in breast cancer survivors. We examined whether past exposure to chemotherapy and/or radiation treatment was associated with DNA damage, telomerase activity, and telomere length 3-6 years after completion of primary treatments in breast cancer survivors (stage 0-IIIA breast cancer at diagnosis). We also examined the relationship of these cellular aging markers with plasma levels of Interleukin (IL)-6, soluble TNF-receptor-II (sTNF-RII), and C-reactive protein (CRP). Ninety-four women (36.4-69.5 years; 80% white) were evaluated. Analyses adjusting for age, race, BMI, and years from last treatment found that women who had prior exposure to chemotherapy and/or radiation compared to women who had previously received surgery alone were more likely to have higher levels of DNA damage (P = .02) and lower telomerase activity (P = .02), but did not have differences in telomere length. More DNA damage and lower telomerase were each associated with higher levels of sTNF-RII (P's < .05). We found that exposure to chemotherapy and/or radiation 3-6 years prior was associated with markers of cellular aging, including higher DNA damage and lower telomerase activity, in post-treatment breast cancer survivors. Furthermore, these measures were associated with elevated inflammatory activation, as indexed by sTNF-RII. Given that these differences were observed many years after the treatment, the findings suggest a long lasting effect of chemotherapy and/or radiation exposure

When a Water Problem Is More Than a Water Problem: Fragmentation, Framing, and the Case of Agricultural Wetland Drainage

Complex interactions between water, society, the economy, and the environment necessitate attention to how water issues are framed, and the limitations of a water-centric framework for analyzing or solving problems. We explore this complexity through an example of an existing complex, or wicked, policy problem—the case of agricultural wetland drainage in the Canadian Prairies. Agricultural wetland drainage expands the amount of productive agricultural land, increasing agricultural efficiency and productivity. Drainage is also one of the primary drivers of the loss of Canada's wetlands and is a hotly contentious issue between actors with divergent views and values in the Canadian Prairies. Using the nuances of drainage as an exemplar, we discuss how fragmented framings of water foster perspectives and solutions that fail to consider the full range of aspects and interactions, and contribute to the enduring conflicts that accompany drainage debates in many regions. First, we discuss agricultural wetland drainage as practiced in the province of Saskatchewan, where significant regulatory and governance changes are in progress. Next, we discuss the challenges of policy and governance fragmentation, both specific to water and to the surrounding system. Finally, we note potential alternative framings that, while specific to prairie water governance, provide guidance for how other complex social-ecological challenges might be approached