The structure of thin zirconia films obtained by self-assembled monolayer mediated deposition: TEM and HREM study

Transmission electron microscopy (TEM), electron energy-loss spectroscopy (EELS) and energy dispersive X-ray analysis (EDX) have been performed on thin zirconia films produced by means of self-assembled monolayer (SAM) mediated deposition from aqueous zirconium sulphate dispersion at 50°C. As-grown films were found to be amorphous. Electron beam irradiation can induce the crystallization of as-grown amorphous zirconia films to tetragonal polycrystalline ZrO2 films. EELS revealed changes in the oxygen K-edge peak caused by the beam-induced structural transition of the amorphous phase to tetragonal ZrO2

Discovery of a Nearby Low-Surface-Brightness Spiral Galaxy

During the course of a search for compact, isolated gas clouds moving with anomalous velocities in or near our own Galaxy (Braun and Burton 1998 A&A, in press), we have discovered, in the data of the Leiden/Dwingeloo survey (Hartmann and Burton 1997, Atlas of Galactic Neutral Hydrogen, CUP) of Galactic hydrogen, the HI signature of a large galaxy, moving at a recession velocity of 282 km/s, with respect to our Galaxy. Deep multicolor and spectroscopic optical observations show the presence of star formation in scattered HII regions; radio HI synthesis interferometry confirms that the galaxy is rich in HI and has the rotation signature of a spiral galaxy; a submillimeter observation failed to detect the CO molecule. The radio and optical evidence combined suggest its classification as a low-surface-brightness spiral galaxy. It is located in close spatial and kinematic proximity to the galaxy NGC 6946. The newly-discovered galaxy, which we call Cepheus 1, is at a distance of about 6 Mpc. It is probably to be numbered amongst the nearest few LSB spirals.Comment: 13 page LaTeX, requires aastex, 4 GIF figures. Accepted for publication in the AJ, January 199

Magnetization switching in a Heisenberg model for small ferromagnetic particles

We investigate the thermally activated magnetization switching of small ferromagnetic particles driven by an external magnetic field. For low uniaxial anisotropy the spins can be expected to rotate coherently, while for sufficient large anisotropy they should behave Ising-like, i.e., the switching should then be due to nucleation. We study this crossover from coherent rotation to nucleation for the classical three-dimensional Heisenberg model with a finite anisotropy. The crossover is influenced by the size of the particle, the strength of the driving magnetic field, and the anisotropy. We discuss the relevant energy barriers which have to be overcome during the switching, and find theoretical arguments which yield the energetically favorable reversal mechanisms for given values of the quantities above. The results are confirmed by Monte Carlo simulations of Heisenberg and Ising models.Comment: 8 pages, Revtex, 11 Figures include

Monte Carlo simulation with time step quantification in terms of Langevin dynamics

For the description of thermally activated dynamics in systems of classical magnetic moments numerical methods are desirable. We consider a simple model for isolated magnetic particles in a uniform field with an oblique angle to the easy axis of the particles. For this model, a comparison of the Monte Carlo method with Langevin dynamics yields new insight in the interpretation of the Monte Carlo process, leading to the implementation of a new algorithm where the Monte Carlo step is time-quantified. The numeric results for the characteristic time of the magnetisation reversal are in excellent agreement with asymptotic solutions which itself are in agreement with the exact numerical results obtained from the Fokker-Planck equation for the Neel-Brown model.Comment: 5 pages, Revtex, 4 Figures include

Neutral Pions and Eta Mesons as Probes of the Hadronic Fireball in Nucleus-Nucleus Collisions around 1A GeV

Chemical and thermal freeze-out of the hadronic fireball formed in symmetric collisions of light, intermediate-mass, and heavy nuclei at beam energies between 0.8A GeV and 2.0A GeV are discussed in terms of an equilibrated, isospin-symmetric ideal hadron gas with grand-canonical baryon-number conservation. For each collision system the baryochemical potential mu_B and the chemical freeze-out temperature T_c are deduced from the inclusive neutral pion and eta yields which are augmented by interpolated data on deuteron production. With increasing beam energy mu_B drops from 800 MeV to 650 MeV, while T_c rises from 55 MeV to 90 MeV. For given beam energy mu_B grows with system size, whereas T_c remains constant. The centrality dependence of the freeze-out parameters is weak as exemplified by the system Au+Au at 0.8A GeV. For the highest beam energies the fraction of nucleons excited to resonance states reaches freeze-out values of nearly 15 %, suggesting resonance densities close to normal nuclear density at maximum compression. In contrast to the particle yields, which convey the status at chemical freeze-out, the shapes of the related transverse-mass spectra do reflect thermal freeze-out. The observed thermal freeze-out temperatures T_th are equal to or slightly lower than T_c, indicative of nearly simultaneous chemical and thermal freeze-out.Comment: 42 pages, 12 figure

Oidium neolycopersici: Intra-specific variability inferred from AFLP analysis and relationship with closely related powdery mildew fungi infecting various plant species

Previous works indicated a considerable variation in the pathogenicity, virulence, and host range of Oidium neolycopersici isolates causing tomato powdery mildew epidemics in many parts of the world. In this study, rDNA internal transcribed spacer (ITS) sequences, and amplified fragment length polymorphism (AFLP) patterns were analyzed in 17 O. neolycopersici samples collected in Europe, North America, and Japan, including those which overcame some of the tomato major resistance genes. The ITS sequences were identical in all 10 samples tested and were also identical to ITS sequences of eight previously studied O. neolycopersici specimens. The AFLP analysis revealed a high genetic diversity in O. neolycopersici and indicated that all 17 samples represented different genotypes. This might suggest the existence of either a yet unrevealed sexual reproduction or other genetic mechanisms that maintain a high genetic variability in O. neolycopersici. No clear correlation was found between the virulence and the AFLP patterns of the O. neolycopersici isolates studied. The relationship between O. neolycopersici and powdery mildew anamorphs infecting Aquilegia vulgaris, Chelidonium majus, Passiflora caerulea, and Sedum alboroseum was also investigated. These anamorphs are morphologically indistinguishable from and phylogenetically closely related to O. neolycopersici. The cross-inoculation tests and the analyses of ITS sequences and AFLP patterns jointly indicated that the powdery mildew anamorphs collected from the above mentioned plant species all represent distinct, but closely related species according to the phylogenetic species recognition. All these species were pathogenic only to their original host plant species, except O. neolycopersici which infected S. alboroseum, tobacco, petunia, and Arabidopsis thaliana, in addition to tomato, in cross-inoculation tests. This is the first genome-wide study that investigates the relationships among powdery mildews that are closely related based on ITS sequences and morphology. The results indicate that morphologically indistinguishable powdery mildews that differed in only one to five single nucleotide positions in their ITS region are to be considered as different taxa with distinct host ranges

Berry's phase and Quantum Dynamics of Ferromagnetic Solitons

We study spin parity effects and the quantum propagation of solitons (Bloch walls) in quasi-one dimensional ferromagnets. Within a coherent state path integral approach we derive a quantum field theory for nonuniform spin configurations. The effective action for the soliton position is shown to contain a gauge potential due to the Berry phase and a damping term caused by the interaction between soliton and spin waves. For temperatures below the anisotropy gap this dissipation reduces to a pure soliton mass renormalization. The gauge potential strongly affects the quantum dynamics of the soliton in a periodic lattice or pinning potential. For half-integer spin, destructive interference between soliton states of opposite chirality suppresses nearest neighbor hopping. Thus the Brillouin zone is halved, and for small mixing of the chiralities the dispersion reveals a surprising dynamical correlation: Two subsequent band minima belong to different chirality states of the soliton. For integer spin, the Berry phase is inoperative and a simple tight-binding dispersion is obtained. Finally it is shown that external fields can be used to interpolate continuously between the Bloch wall dispersions for half-integer and integer spin.Comment: 20 pages, RevTex 3.0 (twocolumn), to appear in Phys. Rev. B 53, 3237 (1996), 4 PS figures available upon reques

Thyroid dysfunction caused by second-generation tyrosine kinase inhibitors in Philadelphia chromosome-positive chronic myeloid leukemia

BACKGROUND: Thyroid dysfunction is a well-known adverse effect of first-generation tyrosine kinase inhibitors (TKIs), like sunitinib. The aim of this study was to investigate the effect of second-generation TKIs on thyroid function. METHODS: We retrospectively assessed the effect of the first-generation TKI imatinib and the second-generation TKI nilotinib and dasatinib on thyroid function tests in 73 Philadelphia chromosome-positive (Ph-positive) chronic myeloid leukemia patients. RESULTS: Overall, 33 of 73 (45%) had one or more thyroid function test abnormalities during follow-up. Hypothyroidism or hyperthyroidism were found in 18 of 73 (25%) and 21 of 73 (29%) cases after a median of 6 and 22 weeks, respectively. In most patients (29 of 39, 74%) thyroid dysfunction was transient without clinical symptoms. Therapy of hypo-/hyperthyroidism was required in three patients. Thyroid dysfunction never resulted in the discontinuation of TKI therapy. Under treatment with imatinib, nilotinib, and dasatinib, thyroid abnormalities were detected in 25%, 55%, and 70%, respectively. Four of 55 patients (7%) treated with nilotinib had evidence for an autoimmune thyroiditis (antibody positive in 3 of 4 patients) with an episode of hyperthyroidism preceding hypothyroidism. CONCLUSIONS: Thyroid dysfunction is a common adverse event with second-generation TKI therapy in patients with Ph-positive chronic myeloid leukemia. Although the mechanism is still unclear, the high frequency of thyroid abnormalities, including autoimmune thyroiditis, warrants regular and long-term monitoring of thyroid function in these patients