Time to Leave Uchronia: Queer Eco-Temporalities for a Livable World

My dissertation is a Feminist contribution to Environmental Political Theory focused on temporality. My research investigates the tension between the urgent need to act fast in a fast-changing world, and the necessity for time to pause and think through such radical and rapid changes. As it signals our nearing the planet’s limits, the emergence of the “anthropocene” crisis challenges growth-driven “progress.” I begin this dissertation with a survey of Environmental Thought that helps situate my contribution to the ongoing debates in this field, underscoring that as ecosophers pose the question of the nonhuman, in so doing they also are confronted with problems related to temporality. Then, building on the concept of “utopia,” I critique a temporality that assumes infinite growth on a planet with finite resources, while constantly postponing its promises of abundance to an impossible future. The concept I propose is “uchronia”: growth-driven progress is a timeless (ou-chronos), dangerously idealized (eu-chronos) temporality, just like “utopia” refers to both a “nowhere” place and an “ideal” place (ou- and eu-topos). I draw from Nietzsche’s concept of eternal return to problematize teleologies of progress: the eternal return prompts us to live our lives as though we were prepared to re-live them eternally. In contrast with uchronia, alternative, queer eco-temporalities – I call these “anti-uchronia,” “heterochronia,” and “synchrony” – build upon and radicalize sustainability. However, not all “eco-temporalities” – alternatives to the hegemonic, in-crisis temporalities – constitute themselves as non-linear or radical – i.e not all of them are queer: I have also coined the concept of “counter-uchronia” to describe certain understandings of “sustainable growth,” justifications of geoengineering and carbon markets creation, as well as primitivist (often virilist) environmentalist discourses which respectively advocate the “return” to a golden past of harmony with (often feminized) “Nature,” or technofixes and green capitalism to amend and resume growth-driven progress’ uchronian course. To advance this conceptual framework, I offer close readings of environmental science fiction stories, activist manifestos, graffiti art, performing arts including contemporary dance and circus, as well as the Intergovernmental Panel on Climate Change scientific reports

Nat Genet

The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.Comment in : Genetic differential calculus. [Nat Genet. 2015] Comment in : Scaling up phenotyping studies. [Nat Biotechnol. 2015

Impact of Mutations in Arabidopsis thaliana Metabolic Pathways on Polerovirus Accumulation, Aphid Performance, and Feeding Behavior

During the process of virus acquisition by aphids, plants respond to both the virus and the aphids by mobilizing different metabolic pathways. It is conceivable that the plant metabolic responses to both aggressors may be conducive to virus acquisition. To address this question, we analyze the accumulation of the phloem-limited poleroviru

Crop domestication as a step towards reproductive isolation

International audienceSpeciation, Darwin’s mystery of mysteries, is a continuous process that results in genomic divergence accompanied by the gradual increment of reproductive barriers between lineages. Since the beginning of research on the genetics of speciation, several questions have emerged such as: What are the genetic bases of incompatibilities? How many loci are necessary to prevent hybridization and how are they distributed along genomes? Can speciation occur despite gene flow and how common is ecological speciation? Early stages of divergence are key to understand the ecology and genetics of speciation, and semi-isolated species where hybrids can still be produced are particularly relevant

Fabrication of Two-Component, Brush-on-Brush Topographical Microstructures by Combination of Atom-Transfer Radical Polymerization with Polymer End-Functionalization and Photopatterning.

Poly(oligoethylene glycol methyl ether methacrylate) (POEGMEMA) brushes, grown from silicon oxide surfaces by surface-initiated atom transfer radical polymerization (SI-ATRP), were end-capped by reaction with sodium azide leading to effective termination of polymerization. Reduction of the terminal azide to an amine, followed by derivatization with the reagent of choice, enabled end-functionalization of the polymers. Reaction with bromoisobutryl bromide yielded a terminal bromine atom that could be used as an initiator for ATRP with a second, contrasting monomer (methacrylic acid). Attachment of a nitrophenyl protecting group to the amine facilitated photopatterning: when the sample was exposed to UV light through a mask, the amine was deprotected in exposed regions, enabling selective bromination and the growth of a patterned brush by ATRP. Using this approach, micropatterned pH-responsive poly(methacrylic acid) (PMAA) brushes were grown on a protein resistant planar poly(oligoethylene glycol methyl ether methacrylate) (POEGMEMA) brush. Atomic force microscopy analysis by tapping mode and PeakForce quantitative nanomechanical mapping (QNM) mode allowed topographical verification of the spatially specific secondary brush growth and its stimulus responsiveness. Chemical confirmation of selective polymer growth was achieved by secondary ion mass spectrometry (SIMS)