DIE EINSCHRÄNKUNG DER VERWENDUNG DER GLAGOLIZA AUF DER SYNODE VON ZADAR 1460

U radu se prikazuje odluka Zadarske sinode od 4. prosinca 1460. na kojoj je nadbiskup Mafej Vallaresso pokušao suzbiti upotrebu liturgije na crkvenoslavenskom jeziku hrvatske redakcije (lingua sclava). Sinodalni akti nisu danas sačuvani već je dostupan samo jedan dio sinodalnog kanona u dvije verzije. Originalnu verziju donosi Carlo F. Bianchi, dok je drugu, neznatno izmijenjenu, pribilježio Ivan Zanotti – Tanzlingher. Poslije interpretcije i konzultacije mjerodavnih vrela zaključuje se kako sinodalna odredba nije posve dokidala liturgijska slavlja na hrvatskom jeziku nego je samo na sinodi poduzet pothvat prostornog i vremenskog suzbijanja »glagoljaške liturgije«. Zadarski su nadbiskupi pokušavali tijekom XVI. stoljeća suzbiti glagoljicu na teritoriju nadbiskupije, ali – kako to pokazuju dostupna vrela – nisu imali znatnijeg uspjeha.In this short discussion author analyzes decisions of the Zadar synod that was held on 4th December 1460. At this diocese council archbishop Mafeo Vallaresso tried to suppress local custom of having the holy service in Church-Slavonic language. The acts from this synod unfortunately are not completely preserved but only one article De celebratione missarum et elebrandi divina official today is known in two versions. The first, and presumably original, version was brought to us by Carlo F. Bianchi, and the second one, just slightly modified, was noted by Ivan Zanotti-Tanzlingher. The both notes deliver basically the same information, and differ only regarding the beginning of this act. Archbishop Vallaresso deeply influenced ecclesiastical life of his diocese at his time: he renovated archbishopric palace, ordered a new bell for the cathedral’s bell tower, and restored organ in the cathedral of St. Anastasia. Still, even though he was a typical renaissance man, he did not care much about the specific local tradition of Zadar and deeply rooted Croatian language. Moreover, through the synod he tried to restrain Glagolitic liturgy only to two town churches: St. Donatus (Holy Trinity) and St. Mary the Great. Similarly, a century later, archbishops of the sixteenth century also tried to suppress Glagolitic script in Zadar, for example on the synods of 1566 and 1594. However, in spite of their endeavors, as it is clearly visible from the extant sources, they did not have much success, and Church Slavonic remained an integral part of local liturgy until the reform of the Second Vatican Council.In dieser kleinen Abhandlung wird die synodale Entscheidung über die Einschränkung der Liturgie in der kirchenslavischen Sprache (der kroatischen Redaktion) analysiert. Der venezianische Patrizier und der Erzbischof von Zadar, Maphäus Vallaresso (1450-1496) hat am 4. Dezember 1460 die Synode in Zadar einberufen; ihre Akten oder Entscheidungen sind nicht erhalten, nur ein kleiner Ausschnitt aus dem Kanon »De celebratione missarum et celebrandi divina officia«. Dieser ist heute in zwei Versionen zugänglich, die sich sprachlich nur geringfügig voneinander unterscheiden. Die Originalversion hat schon Carlo F. Bianchi veröffentlicht und die zweite hat Johannes Zanotti – Tanzlingher in seinem Werk Epitome synodorum dioecesis Iadrensis vermerkt. Die synodale Entscheidung versucht die Liturgie in der kirchenslavischen Sprache der kroatischen Redaktion für bestimmte Zeit nur auf zwei Kirchen in Zadar zu reduzieren: Die Kirche der Hl. Dreifaltigkeit (heute hl. Donat) und die Kirche der hl. Maria. Diese Entscheidung ließ sich nicht verwirklichen, da die Liturgie in lingua slava (d. h. in kroatischer Sprache) eine lange Tradition hat und in allen Pfarreien verbreitet war. Die Erzbischöfe von Zadar, Mutius Callinus (1555-1566) und auch Aloysius Molinus (1592-1595) haben diese Entscheidung auf den Synoden 1566 und 1594 noch einmal verbindlich erklärt; die Versuche sind gescheitert. Erzbischof Oktavian Garzzadoro (1623-1644), der aus gesundheitlichen Gründen Papst Urban VIII. um die Entbindung von den Pflichten bat, fügte seiner Begründung hinzu, dass er die Sprache der Gläubigen seines Bistums nicht versteht. Dies ist ein klarer Beweis dafür, dass in Zadar die Bevölkerung kroatisch gesprochen hat und die Liturgie bis zur Reform des II. Vatikanischen Konzils in der Landessprache gefeiert wurde

Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes